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Type I Interferon-Driven Monocyte Dysregulation and MAS-associated CD8+ T cells During Macrophage Activation Syndrome
bioRxivSusan P Canny, Hannah A DeBerg, Emma L Kuan, Nicholas Moss, Griffin Gessay, Ailing Lu, Amanda Huang, Allison R O’Rourke, Erik D Layton, Paige Bouvatte, Peter J Wittig, Cate Speake, Carmen Mikacenic, Susan Shenoi, Joyce Hui-Yuen, Daniel J Campbell, Betsy J Barnes, Jessica A Hamerman -
Differential effects of subcutaneous and sublingual immunotherapy on timothy grass-specific TH2 CD4+ T-cell subsets
J Allergy Clin ImmunolHannah A DeBerg, Carolyn H Baloh, Quinn DeGottardi, Jue Hou, Alexandra Johansson, Evan Newell, Tanya M Laidlaw, Srinath Sanda, Mohamed Shamji, Stephen Durham, Alkis Togias, William W Kwok -
Longitudinally stable T cell function and innate immune activation distinguish healthy adult immunotypes.
Sci Transl MedSmithmyer ME, Hu A, Dufort MJ, Hocking AM, Wiedeman AE, Fasano KJ, Torgerson TR, Skene PJ, Reading J, Li X, Gong Q, Long SA, Lacy-Hulbert A, Gustafson CE, Buckner JH, Speake C, members of the BRI Sound Life Project Team, BRI Sound Life Project Team -
Phase 1 study of safety, tolerability, and efficacy of intradermal DNA vaccine ASP2390 in adults allergic to house dust mites
J Allergy Clin Immunol GlobThomas Kayser, Ronald Smulders, Tomohiro Kusawake, Erik Wambre, Gurunadh R Chichili, Mary B Blauwet, Anna Spence, Melanie Patton, Rima Tabash, Hannah A DeBerg, Sugandhika Khosa, Philipp Badorrek, Jens M Hohlfeld, Brian C Ferslew -
T cells promote distinct transcriptional programs of cutaneous inflammatory disease in keratinocytes and dermal fibroblasts
J Invest DermatolHannah A DeBerg, Mitch L Fahning, Suraj R Varkhande, James D Schlenker, William P Schmitt, Aayush Gupta, Archana Singh, Iris K Gratz, Jeffrey S Carlin, Daniel J Campbell, Peter A Morawski -
Defining a novel DYRK1A-gp130/IL-6R-pSTAT axis that regulates Th17 differentiation.
ImmunohorizonsMalueg M, Moo KG, Arnett A, Edwards TH, Ruskin SL, Lambert K, Subramanyam A, Dufort MJ, Gersuk VH, Partridge R, Buckner JH, Khor B -
Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling.
ImmunityOgishi M, Kitaoka K, Good-Jacobson KL, Rinchai D, Zhang B, Wang J, Gies V, Rao G, Nguyen T, Avery DT, Khan T, Smithmyer ME, Mackie J, Yang R, Arias AA, Asano T, Ponsin K, Chaldebas M, Zhang P, Peel JN, Bohlen J, Lévy R, Pelham SJ, Lei WT, Han JE, Fagniez I, Chrabieh M, Laine C, Langlais D, Gruber C, Al Ali F, Rahman M, Aytekin C, Benson B, Dufort MJ, Domingo-Vila C, Moriya K, Shlomchik M, Uzel G, Gray PE, Suan D, Preece K, Chua I, Okada S, Chikuma S, Kiyonari H, Tree TI, Bogunovic D, Gros P, Marr N, Speake C, Oram RA, Béziat V, Bustamante J, Abel L, Boisson B, Korganow AS, Ma CS, Johnson MB, Chamoto K, Boisson-Dupuis S, Honjo T, Casanova JL, Tangye SG -
Hypoxia-inducible factor 2α promotes protective Th2 cell responses during intestinal helminth infection.
J ImmunolLabuda JC, Olsen TM, Verma S, Kimmel S, Edwards TH, Dufort MJ, Harrison OJ -
An IL-2 mutein increases regulatory T cell suppression of dendritic cells via IL-10 and CTLA-4 to promote T cell anergy.
Cell RepJamison BL, Lawrance M, Wang CJ, DeBerg HA, Ziegler LJ, Sansom DM, Gavin MA, Walker LSK, Campbell DJ -
Genetic and epigenetic screens in primary human T cells link candidate causal autoimmune variants to T cell networks
Nat GenetChing-Huang Ho, Maxwell A Dippel, Meghan S McQuade, LeAnn P Nguyen, Arpit Mishra, Stephan Pribitzer, Samantha Hardy, Harshpreet Chandok, Florence M Chardon, Troy A McDiarmid, Hannah A DeBerg, Jane H Buckner , Jay Shendure, Carl G de Boer, Michael H Guo, Ryan Tewhey, John P Ray -
T cells promote distinct transcriptional programs of cutaneous inflammatory disease in keratinocytes and dermal fibroblasts.
bioRxivDeBerg HA, Fahning ML, Varkhande SR, Schlenker JD, Schmitt WP, Gupta A, Singh A, Gratz IK, Carlin JS, Campbell DJ, Morawski PA -
Lupus IgA1 autoantibodies synergize with IgG to enhance plasmacytoid dendritic cell responses to RNA-containing immune complexes.
Sci Transl MedWaterman HR, Dufort MJ, Posso SE, Ni M, Li LZ, Zhu C, Raj P, Smith KD, Buckner JH, Hamerman JA -
Antigen-level resolution of commensal-specific B cell responses can be enabled by phage display screening coupled with B cell tetramers.
ImmunityVerma S, Dufort MJ, Olsen TM, Kimmel S, Labuda JC, Scharffenberger S, McGuire AT, Harrison OJ -
Human inherited PD-L1 deficiency is clinically and immunologically less severe than PD-1 deficiency.
J Exp MedJohnson MB, Ogishi M, Domingo-Vila C, de Franco E, Wakeling MN, Imane Z, Resnick B, Williams E, Galão RP, Caswell R, Russ-Silsby J, Seeleuthner Y, Rinchai D, Fagniez I, Benson B, Dufort MJ, Speake C, Smithmyer ME, Hudson M, Dobbs R, EXE-T1D consortium, Quandt Z, Hattersley AT, Zhang P, Boisson-Dupuis S, Anderson MS, Casanova JL, Tree TI, Oram RA -
Phase 1 trial supports safety and mechanism of action of peptide immunotherapy for peanut allergy.
AllergyVoskamp AL, Khosa S, Phan T, DeBerg HA, Bingham J, Hew M, Smith W, Abramovitch J, Rolland JM, Moyle M, Nadeau KC, Lack G, Larché M, Wambre E, O'Hehir RE, Hickey P, Prickett SR
