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Integrated histopathology of the human pancreas throughout stages of type 1 diabetes progression
Nat CommunVerena van der Heide, Sara McArdle, Michael S Nelson, Karen Cerosaletti, Sacha Gnjatic, Zbigniew Mikulski, Amanda L Posgai, Irina Kusmartseva, Mark A Atkinson, Dirk Homann -
Genetic Determinants of Peanut-Specific IgG4 Levels in the Context of Sustained Oral Peanut Exposure in the LEAP Study
ImmunologyKanika Kanchan, Karen Cerosaletti, James A Perry, George DuToit, Monali Manohar, Hua Ling, Justin E Paschall, Srinath Sanda, R Sharon Chinthrajah, Gerald T Nepom, Kari C Nadeau, Stacie M Jones, Gideon Lack, Ingo Ruczinski, Rasika A Mathias -
Expanding the Case for Hybrid Insulin Peptides in Type 1 Diabetes.
DiabetesCerosaletti K, Kent SC -
Functional dissection of noncoding variants associated with rheumatoid arthritis
Ann Rheum DisAjay Jajodia, Arpit Mishra, Naresh Doni Jayavelu, Katharina Lambert, Nicholas Moss, Zongchen Yang, Karen Cerosaletti, Jane H Buckner , R David Hawkins -
A molecular basis for milk allergen immune recognition in eosinophilic esophagitis.
J Allergy Clin ImmunolDilollo J, Hu A, Qu H, Canziani KE, Clement RL, McCright SJ, Shreffler WG, Hakonarson H, Spergel JM, Cerosaletti K, Hill DA -
The Type 1 Diabetes T Cell Receptor and B Cell Receptor Repository in the AIRR Data Commons: a practical guide for access, use and contributions through the Type 1 Diabetes AIRR Consortium.
DiabetologiaHanna SJ, Bonami RH, Corrie B, Westley M, Posgai AL, Luning Prak ET, Breden F, Michels AW, Brusko TM, Type 1 Diabetes AIRR Consortium, Karen Cerosaletti, Peter S Linsley -
Identification of a novel PDC-E2 epitope in primary biliary cholangitis: Application for engineered Treg therapy.
J AutoimmunTewari R, Yang SJ, McClain ED, Hu A, Mortensen E, DeSchmidt A, Chen J, Kancharla A, Singh AK, James EA, Burman BE, Siddique A, Rawlings DJ, Patel C, Cerosaletti K, Buckner JH -
IKZF1 and UBR4 gene variants drive autoimmunity and TH2 polarization in IgG4-related disease.
J Clin InvestLiu Q, Zheng Y, Sturmlechner I, Jain A, Own M, Yang Q, Zhang H, Pinto E Vairo F, Cerosaletti K, Buckner JH, Warrington KJ, Koster MJ, Weyand CM, Goronzy JJ -
Germline-like TCR-α chains shared between autoreactive T cells in blood and pancreas.
Nat CommunLinsley PS, Nakayama M, Balmas E, Chen J, Barahmand-Pour-Whitman F, Bansal S, Bottorff T, Serti E, Speake C, Pugliese A, Cerosaletti K -
GNTI-122: an autologous antigen-specific engineered Treg cell therapy for type 1 diabetes.
JCI InsightUenishi GI, Repic M, Yam JY, Landuyt A, Saikumar-Lakshmi P, Guo T, Zarin P, Sassone-Corsi M, Chicoine A, Kellogg H, Hunt M, Drow T, Tewari R, Cook PJ, Yang SJ, Cerosaletti K, Schweinoch D, Guiastrennec B, James E, Patel C, Chen TF, Buckner JH, Rawlings DJ, Wickham TJ, Mueller KT -
Self-reactive germline-like TCR alpha chains shared between blood and pancreas.
Res SqLinsley P, Nakayama M, Balmas E, Chen J, Pour F, Bansal S, Serti E, Speake C, Pugliese A, Cerosaletti K -
A first-in-human, open-label Phase 1b and a randomised, double-blind Phase 2a clinical trial in recent-onset type 1 diabetes with AG019 as monotherapy and in combination with teplizumab.
DiabetologiaMathieu C, Wiedeman A, Cerosaletti K, Long SA, Serti E, Cooney L, Vermeiren J, Caluwaerts S, Van Huynegem K, Steidler L, Blomme S, Rottiers P, Nepom GT, Herold KC, AG019-T1D-101 Trial Investigators -
Shifts in isoform usage underlie transcriptional differences in regulatory T cells in type 1 diabetes.
Commun BiolNewman JRB, Long SA, Speake C, Greenbaum CJ, Cerosaletti K, Rich SS, Onengut-Gumuscu S, McIntyre LM, Buckner JH, Concannon P -
Proinflammatory islet antigen reactive CD4 T cells are linked with response to alefacept in type 1 diabetes.
JCI InsightBalmas E, Chen J, Hu AK, DeBerg HA, Rosasco MG, Gersuk VH, Serti E, Speake C, Greenbaum CJ, Nepom GT, Linsley PS, Cerosaletti K -
PTPN22 R620W gene editing in T cells enhances low avidity TCR responses.
ElifeAnderson W, Barahmand-Pour-Whitman F, Linsley PS, Cerosaletti K, Buckner JH, Rawlings DJ
