2016 BRI Publications

The following list highlights BRI's publications from 2016. More selective listings of publications are included on scientist biography pages. Featured BRI scientists are listed in bold.

January - March

  1. Blazkova J, Boughorbel S, Presnell S, Quinn C, Chaussabel D. A curated transcriptome dataset collection to investigate the immunobiology of HIV infection. F1000Res. 2016 Mar 11;5:327. doi: 10.12688/f1000research.8204.1. eCollection 2016. PMID: 27134731

  2. Braasch I, Gehrke AR, Smith JJ, Kawasaki K, Manousaki T, Pasquier J, Amores A, Desvignes T, Batzel P, Catchen J, Berlin AM, Campbell MS, Barrell D, Martin KJ, Mulley JF, Ravi V, Lee AP, Nakamura T, Chalopin D, Fan S, Wcisel D, Cañestro C, Sydes J, Beaudry FE, Sun Y, Hertel J, Beam MJ, Fasold M, Ishiyama M, Johnson J, Kehr S, Lara M, Letaw JH, Litman GW, Litman RT, Mikami M, Ota T, Saha NR, Williams L, Stadler PF, Wang H, Taylor JS, Fontenot Q, Ferrara A, Searle SM, Aken B, Yandell M, Schneider I, Yoder JA, Volff JN, Meyer A, Amemiya CT, Venkatesh B, Holland PW, Guiguen Y, Bobe J, Shubin NH, Di Palma F, Alföldi J, Lindblad-Toh K, Postlethwait JH. The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nat Genet. 2016 Mar 7. doi: 10.1038/ng.3526. PMID: 26950095

  3. Buckner JH, Nepom GT. Obstacles and opportunities for targeting the effector T cell response in type 1 diabetes. J Autoimmun. 2016 Mar 3. pii: S0896-8411(16)30011-7. doi: 10.1016/j.jaut.2016.02.009. PMID: 26948997

  4. Clemente-Casares X, Blanco J, Ambalavanan P, Yamanouchi J, Singha S, Fandos C, Tsai S, Wang J, Garabatos N, Izquierdo C, Agrawal S, Keough MB, Yong VW, James EA, Moore A, Yang Y, Stratmann T, Serra P, Santamaria P. Expanding antigen-specific regulatory networks to treat autoimmunity. Nature. 2016 Feb 25;530(7591):434-40. doi: 10.1038/nature16962. Epub 2016 Feb 17. PMID: 26886799

  5. Jackson SW, Jacobs HM, Arkatkar T, Dam EM, Scharping NE, Kolhatkar NS, Hou B, Buckner JH, Rawlings DJ. AI-18 B cell IFN-γ receptor signalling promotes autoimmune germinal centresvia cell-intrinsic induction of BCL-6. Lupus Sci Med 2016;3: doi:10.1136/lupus-2016-000179.18. PMID: 27069113

  6. James EA, Gates TJ, LaFond RE, Yamamoto S, Ni C, Mai D, Gersuk VH, O'Brien K, Nguyen QA, Zeitner B, Lanteri MC, Norris PJ, Chaussabel D, Malhotra U, Kwok WW. Neuroinvasive West Nile Infection Elicits Elevated and Atypically Polarized T Cell Responses That Promote a Pathogenic Outcome. PLoS Pathog. 2016 Jan 21;12(1):e1005375. doi: 10.1371/journal.ppat.1005375. eCollection 2016 Jan. PMID: 26795118

  7. Kuipers HF, Rieck M, Gurevich I, Butte MJ, Negrin RS, Wight TN, Steinman L, Bollyky PL. Hyaluronan synthesis is necessary for autoreactive T cell trafficking, activation, and Th1 polarization. Proc Natl Acad Sci U S A. 113:1339-44, 2016. PMID: 26787861

  8. Lehmann-Werman R, Neiman D, Zemmour H, Moss J, Magenheim J, Vaknin-Dembinsky A, Rubertsson S, Nellgård B, Blennow K, Zetterberg H, Spalding K, Haller MJ, Wasserfall CH, Schatz DA, Greenbaum CJ, Dorrell C, Grompe M, Zick A, Hubert A, Maoz M, Fendrich V, Bartsch DK, Golan T, Ben Sasson SA, Zamir G, Razin A, Cedar H, Shapiro AM, Glaser B, Shemer R, Dor Y. Identification of tissue-specific cell death using methylation patterns of circulating DNA. Proc Nat'l Acad Sci USA, 2016 Mar 19. PMID: 26976580

  9. Lombardi V, Beuraud C, Neukirch C, Moussu H, Morizur L, Horiot S, Luce S, Wambre E, Linsley P, Chollet-Martin S, Baron-Bodo V, Aubier M, Moingeon P. Circulating innate lymphoid cells are differentially regulated in allergic and nonallergic subjects. J Allergy Clin Immunol. 2016 Mar 3. pii: S0091-6749(16)00187-1. doi: 10.1016/j.jaci.2015.12.1325. PMID: 26949057

  10. Marr AK, Boughorbel S, Presnell S, Quinn C, Chaussabel D, Kino T. A curated transcriptome dataset collection to investigate the development and differentiation of the human placenta and its associated pathologies. Version 2. F1000Res. 2016 Mar 9;5:305. doi: 10.12688/f1000research.8210.2. eCollection 2016. PMID: 27303626

  11. Meah FA, DiMeglio LA, Greenbaum CJ, Blum JS, Sosenko JM, Pugliese A, Geyer S, Xu P, Evans-Molina C; Type 1 Diabetes TrialNet Study Group. The relationship between BMI and insulin resistance and progression from single to multiple autoantibody positive and type 1 diabetes among TrialNet Pathways to Prevention participants. Diabetologia, 2016 Mar 19. PMID: 26995649

  12. Qin J, Fu S, Speake C, Greenbaum CJ, Odegard JM. NETosis-associated serum biomarkers are reduced in type11 diabetes in association with neutrophil count. Clin Exp Immunol, 2016 Mar 3. PMID: 26939803

  13. Rahman M, Boughorbel S, Presnell S, Quinn C, Cugno C, Chaussabel D, Marr N. A curated transcriptome dataset collection to investigate the functional programming of human hematopoietic cells in early life. F1000Res. 2016 Mar 30;5:414. doi: 10.12688/f1000research.8375.1. eCollection 2016. PMID: 27347375

  14. Raj P, Li Q-Z, Dozmorov I, Olsen NJ, Sivils K, Kelly J, James JA, Lauwerys B, Gregersen P, Cerosaletti K, Karp DR, Wakeland EK. GG-07 SLE risk haplotypes are associated with development of serologic autoimmunity in healthy individuals. Lupus Sci Med 2016;3: doi:10.1136/lupus-2016-000179.59

  15. Redondo MJ, Grant SF, Davis A, Greenbaum CJ; T1D Exchange Biobank. Dissecting heterogeneity in pediatric Type 1 diabetes: association of TCF7L2 rs7903146 TT and low-risk human leukocyte antigen (HLA) genotypes. Diabet Med 2016 Mar 30. PMID: 27027642

  16. Renand A, Robinson D, Kwok WW. Reply. J Allergy Clin Immunol. 2016 Mar 10. pii: S0091-6749(16)00196-2. doi: 10.1016/j.jaci.2015.11.046. PMID: 26971693

  17. Rinchai D, Boughorbel S, Presnell S, Quinn C, Chaussabel D. A compendium of monocyte transcriptome datasets to foster biomedical knowledge discovery. F1000Res. 2016 Mar 7;5:291. doi: 10.12688/f1000research.8182.1. eCollection 2016. PMID: 27158451

  18. Roan F, Stoklasek TA, Whalen E, Molitor JA, Bluestone JA, Buckner JH, Ziegler SF. CD4+ Group 1 Innate Lymphoid Cells (ILC) Form a Functionally Distinct ILC Subset That Is Increased in Systemic Sclerosis. J Immunol. 2016 Mar 1;196(5):2051-62. PMID: 26826243

  19. Spindler MP, Ho AM, Tridgell D, McCulloch-Olson M, Gersuk V, Ni C, Greenbaum CJ, Sanda S. Acute hyperglycemia impairs IL-6 expression in humans. Immun Inflamm Dis. 2016 Jan 19;4(1):91-7. eCollection 2016 Mar. PMID: 27042306

  20. Thompson LJ, Lai JF, Valladao AC, Thelen TD, Urry ZL, Ziegler SF. Conditioning of naive CD4(+) T cells for enhanced peripheral Foxp3 induction by nonspecific bystander inflammation. Nat Immunol. 2016 Mar;17(3):297-303. PMID: 26752376

  21. Vendrame F, Hopfner YY, Diamantopoulos S, Virdi SK, Allende G, Snowhite IV, Reijonen HK, Chen L, Ruiz P, Ciancio G, Hutton JC, Messinger S, Burke GW 3rd, Pugliese A. Risk Factors for Type 1 Diabetes Recurrence in Immunosuppressed Recipients of Simultaneous Pancreas-Kidney Transplants. Am J Transplant. 2016 Jan;16(1):235-45. doi: 10.1111/ajt.13426. Epub 2015 Aug 28. PMID: 26317167

  22. Wherrett DK, Chiang JL, Delamater AM, DiMeglio LA, Gitelman SE, Gottlieb PA, Herold KC, Lovell DJ, Orchard TJ, Ryan CM, Schatz DA, Wendler DS, Greenbaum CJ; Type 1 Diabetes TrialNet Study Group. Defining pathways for development of disease-modifying therapies in children with type 1 diabetes: a consensus report. Diabetes Care, 2015 Oct;38(10):1975-85. Review. PMID: 26404927

April - June

  1. Acharya M, Sokolovska A, Tam JM, Conway KL, Stefani C, Raso F, Mukhopadhyay S, Feliu M, Paul E, Savill J, Hynes RO, Xavier RJ, Vyas JM, Stuart LM, Lacy-Hulbert A. αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells. Nat Commun. 2016 Mar 11;7:10917. doi: 10.1038/ncomms10917. PMID: 26965188

  2. Ali, R; Babad, J; Follenzi, A; Gebe, J; Brehm, M; Nepom, G; Shultz, L; Greiner, D; DiLorenzo, T. Genetically Modified Human CD4+ T Cells Can Be Evaluated In Vivo Without Lethal Graft Versus Host Disease.  Immunology. 2016 Apr 28. doi: 10.1111/imm.12613. PMID: 27124592

  3. Bryant SA, Herdy JR, Amemiya CT, Smith JJ. Characterization of Somatically-Eliminated Genes During Development of the Sea Lamprey (Petromyzon marinus). Mol Biol Evol. 2016 Jun 10. pii: msw104. PMID: 27288344

  4. Gan RW, Demoruelle MK, Deane KD, Weisman MH, Buckner JH, Gregersen PK, Mikuls TR, O'Dell JR, Keating RM, Fingerlin TE, Zerbe GO, Clare-Salzler MJ, Holers VM, Norris JM. Omega-3 fatty acids are associated with a lower prevalence of autoantibodies in shared epitope-positive subjects at risk for rheumatoid arthritis. Ann Rheum Dis. 2016 May 17. pii: annrheumdis-2016-209154. doi: 10.1136/annrheumdis-2016-209154. PMID: 27190099

  5. Glatigny S, Wagner CA, Bettelli E. Cutting Edge: Integrin α4 Is Required for Regulatory B Cell Control of Experimental Autoimmune Encephalomyelitis. J Immunol. 2016 May 1;196(9):3542-6. doi: 10.4049/jimmunol.1502614. PMID: 27016608

  6. Josberger EE, Hassanzadeh P, Deng Y, Sohn J, Rego M, Amemiya CT, Rolandi M. Proton conductivity in ampullae of Lorenzini jelly. Science Advances. 13 May 2016: Vol. 2, no. 5, e1600112 DOI: 10.1126/sciadv.1600112. PMID: 27386543

  7. Karthikeyan K, Barker K, Tang Y, Kahn P, Wiktor P, Brunner A, Knabben V, Takulapalli B, Buckner J, Nepom G, LaBaer J, Qiu J. A contra capture protein array platform for studying post-translationally modified auto-antigenomes. Mol Cell Proteomics. 2016 May 2. pii: mcp.M115.057661. PMID: 27141097

  8. Kuipers HF, Nagy N, Ruppert SM, Sunkari VG, Marshall PL, Gebe JA, Ishak HD, Keswani SG, Bollyky J, Frymoyer AR, Wight TN, Steinman L, Bollyky PL. The Pharmacokinetics and Dosing of Oral 4-Methylumbelliferone for Inhibition of Hyaluronan Synthesis in Mice. Clin Exp Immunol. 2016 May 24. doi: 10.1111/cei.12815. PMID: 27218304

  9. Lorente E, Barriga A, Barnea E, Mir C, Gebe JA, Admon A, López D. Structural and nonstructural viral proteins are targets of T-helper immune response against human respiratory syncytial virus. Mol Cell Proteomics. 2016 Jun;15(6):2141-51. doi: 10.1074/mcp.M115.057356. PMID: 27090790

  10. Merrilees MJ, Zuo N, Evanko SP, Day AJ, Wight TN. G1 domain of versican regulates hyaluronan organization and the phenotype of cultured human dermal fibroblasts. J Histochem Cytochem. 2016 Jun;64(6):353-63. doi: 10.1369/0022155416643913. PMID: 27126822

  11. Pinckney A, Rigby MR, Keyes-Elstein L, Soppe CL, Nepom GT, Ehlers MR. Correlation Among Hypoglycemia, Glycemic Variability, and C-Peptide Preservation After Alefacept Therapy in Patients with Type 1 Diabetes Mellitus: Analysis of Data from the Immune Tolerance Network T1DAL Trial. Clin Ther. 2016 May 18. pii: S0149-2918(16)30266-1. doi: 10.1016/j.clinthera.2016.04.032. PMID: 27209482

  12. Reeves SR, Kaber G, Sheih A, Cheng G, Aronica MA, Merrilees MJ, Debley JS, Frevert CW, Ziegler SF, Wight TN.  Subepithelial accumulation of versican in a cockroach antigen-induced murine model of allergic asthma. J Histochem Cytochem. 2016 Jun;64(6):364-80. doi: 10.1369/0022155416642989. PMID: 27126823

  13. Rinchai D, Boughorbel S, Presnell S, Quinn C, Chaussabel D. A curated compendium of monocyte transcriptome datasets of relevance to human monocyte immunobiology research. F1000Res. 2016 Apr 25;5:291. doi: 10.12688/f1000research.8182.2. eCollection 2016. PMID: 27158452

  14. Scholz E, Mestre-Ferrer A, Daura X, García-Medel N, Carrascal M, James EA, Kwok WW, Canals F, Alvarez I. A comparative analysis of the peptide repertoires of HLA-DR molecules differentially associated to rheumatoid arthritis. Arthritis Rheumatol. 2016 May 9. doi: 10.1002/art.39736. PMID: 27158783

  15. Tam JM, Mansour MK, Acharya M, Sokolovska A, Timmons AK, Lacy-Hulbert A, Vyas JM. The Role of Autophagy-Related Proteins in Candida albicans Infections. Pathogens. 2016 Mar 29;5(2). pii: E34. doi: 10.3390/pathogens5020034. PMID: 27043636

July - September

  1. Asare AL, Carey VJ, Rotrosen D, Nepom GT. Clinical trial data access: Opening doors with TrialShare. J Allergy Clin Immunol. 2016 Sep;138(3):724-6. doi: 10.1016/j.jaci.2016.05.034. Epub 2016 Jul 12. PMID: 27474121

  2. Boucard-Jourdin M, Kugler D, Endale Ahanda ML, This S, De Calisto J, Zhang A, Mora JR, Stuart LM, Savill J, Lacy-Hulbert A, Paidassi H. β8 Integrin Expression and Activation of TGF-β by Intestinal Dendritic Cells Are Determined by Both Tissue Microenvironment and Cell Lineage. J Immunol. 2016 Sep 1;197(5):1968-78. doi: 10.4049/jimmunol.1600244. Epub 2016 Aug 1. PMID: 27481847

  3. Buechler MB, Akilesh HM, Hamerman JA. Cutting Edge: Direct Sensing of TLR7 Ligands and Type I IFN by the Common Myeloid Progenitor Promotes mTOR/PI3K-Dependent Emergency Myelopoiesis. J Immunol. 2016 Aug 26. pii: 1600813. PMID: 27566824

  4. Doedens JR, Jones WD, Hill K, Mason MJ, Gersuk VH, Mease PJ, Dall'Era M, Aranow C, Martin RW, Cohen SB, Fleischmann RM, Kivitz AJ, Burge DJ, Chaussabel D, Elkon KB, Posada JA. Blood-Borne RNA Correlates with Disease Activity and IFN-Stimulated Gene Expression in Systemic Lupus Erythematosus. J Immunol. 2016 Aug 17. pii: 1601142. PMID: 27534558

  5. Du F, Garg AV, Kosar K, Majumder S, Kugler DG, Mir GH, Maggio M, Henkel M, Lacy-Hulbert A, McGeachy MJ. Inflammatory Th17 Cells Express Integrin αvβ3 for Pathogenic Function. Cell Rep. 2016 Aug 2;16(5):1339-51. doi: 10.1016/j.celrep.2016.06.065. Epub 2016 Jul 21. PMID: 27452457

  6. Ettinger RA, Paz P, James EA, Gunasekera D, Aswad F, Thompson AR, Matthews DC, Pratt KP. T cells from three Hemophilia A subjects recognized the same HLA-restricted FVIII epitope with a narrow TCR repertoire. Blood. 2016 Jul 28. pii: blood-2015-11-682468. PMID: 27471234

  7. Gebe JA, Yadava K, Ruppert SM, Marshall P, Hill P, Falk BA, Sweere JM, Han H, Kaber G, Medina C, Mikecz K, Ziegler SF, Balaji S, Keswani SG, de Jesus Perez VA, Butte MJ, Nadeau K, Altemeier WA, Fanger N, Bollyky PL. Modified High Molecular Weight Hyaluronan Promotes Allergen-Specific Immune Tolerance. Am J Respir Cell Mol Biol. 2016 Sep 6. PMID: 27598620

  8. Hao W, Gitelman S, DiMeglio LA, Boulware D, Greenbaum CJ; Type 1 Diabetes TrialNet Study Group. Fall in C-Peptide During First 4 Years From Diagnosis of Type 1 Diabetes: Variable Relation to Age, HbA1c, and Insulin Dose. Diabetes Care. 2016 Jul 15. pii: dc160360. PMID: 27422577

  9. Hundhausen C, Roth A, Whalen E , Chen J, Schneider A, Long SA, Wei S, Rawlings R, Kinsman M, Evanko SP, Wight TN, Greenbaum CJ, Cerosaletti K, Buckner JH. Enhanced T cell responses to IL-6 in type 1 diabetes are associated with early clinical disease and increased IL-6 receptor expression. Sci Transl Med. 2016 Sep 14;8(356):356ra119. PMID: 27629486

  10. Johnson MC, Pierson ER, Spieker AJ, Nielsen AS, Posso S, Kita M, Buckner JH, Goverman JM. Distinct T cell signatures define subsets of patients with multiple sclerosis. Neurol Neuroimmunol Neuroinflamm. 2016 Aug 23;3(5):e278. doi: 10.1212/NXI.0000000000000278. eCollection 2016. PMID: 27606354

  11. Koch J, Lüdemann J, Spies R, Last M, Amemiya CT, Burmester T. 2016. Unusual diversity of myoglobin genes in the lungfish. Mol. Biol. Evol. pii: msw159. PMID: 27512111

  12. Muehling LM, Mai DT, Kwok WW, Heymann PW, Pomés A, Woodfolk JA. Circulating Memory CD4+ T Cells Target Conserved Epitopes of Rhinovirus Capsid Proteins and Respond Rapidly to Experimental Infection in Humans. J Immunol. 2016 Sep 2. pii: 1600663. PMID: 27591323

  13. Nelson JE, Roth CL, Wilson LA, Yates KP, Aouizerat B, Morgan-Stevenson V, Whalen E, Hoofnagle A, Mason M, Gersuk V, Yeh MM, Kowdley KV. Vitamin D Deficiency Is Associated With Increased Risk of Non-alcoholic Steatohepatitis in Adults With Non-alcoholic Fatty Liver Disease: Possible Role for MAPK and NF-κB? Am J Gastroenterol. 2016 Jun;111(6):852-63. doi: 10.1038/ajg.2016.51. Epub 2016 Mar 22. PMID: 27002799

  14. Nguyen H, James EA. Immune recognition of citrullinated epitopes. Immunology. 2016 Oct;149(2):131-8. doi: 10.1111/imm.12640. Epub 2016 Aug 17. Review. PMID: 27531825

  15. Nuttle X, Giannuzzi G, Duyzend MH, Schraiber JG, Narvaiza I, Sudmant PH, Penn O, Chiatante G, Malig M, Huddleston J, Benner C, Camponeschi F, Ciofi-Baffoni S, Stessman HA, Marchetto MC, Denman L, Harshman L, Baker C, Raja A, Penewit K, Janke N, Tang WJ, Ventura M, Banci L, Antonacci F, Akey JM, Amemiya CT, Gage FH, Reymond A, Eichler EE. Emergence of a Homo sapiens-specific gene family and chromosome 16p11.2 CNV susceptibility. Nature. 2016 Aug 11;536(7615):205-9. PMID: 27487209

  16. Piliponsky AM, Lahiri A, Truong P, Clauson M, Shubin NJ, Han H, Ziegler SF. Thymic Stromal Lymphopoietin Improves Survival and Reduces Inflammation in Sepsis. Am J Respir Cell Mol Biol. 2016 Aug;55(2):264-74. doi: 10.1165/rcmb.2015-0380OC. PMID: 26934097

  17. Presnell JS, Vandepas LE, Warren KJ, Swalla BJ, Amemiya CT, Browne WE. 2016. The Presence of a Functionally Tripartite Through-Gut in Ctenophora Has Implications for Metazoan Character Trait Evolution. Curr. Biol. 2016 Aug 24. pii: S0960-9822(16)30931-9. doi: 10.1016/j.cub.2016.08.019. PMID: 27568594

  18. Sparks JA, Chang SC, Deane KD, Gan RW, Kristen Demoruelle M, Feser ML, Moss L, Buckner JH, Keating RM, Costenbader KH, Gregersen PK, Weisman MH, Mikuls TR, O'Dell JR, Michael Holers V, Norris JM, Karlson EW. Associations of Smoking and Age With Inflammatory Joint Signs Among Unaffected First-Degree Relatives of Rheumatoid Arthritis Patients: Results From Studies of the Etiology of Rheumatoid Arthritis. Arthritis Rheumatol. 2016 Aug;68(8):1828-38. doi: 10.1002/art.39630. PMID: 26866831

  19. Sprouse ML, Blahnik G, Lee T, Tully N, Banerjee P, James EA, Redondo MJ, Bettini ML, Bettini M. Rapid identification and expression of human TCRs in retrogenic mice. J Immunol Methods. 2016 Aug 30. pii: S0022-1759(16)30167-3. doi: 10.1016/j.jim.2016.08.010. PMID: 27589924

  20. Stolley JM, Campbell DJ. A 33D1+ Dendritic Cell/Autoreactive CD4+ T Cell Circuit Maintains IL-2-Dependent Regulatory T Cells in the Spleen. J Immunol. 2016 Aug 26. pii: 1600974. PMID: 27566821

  21. Thelen TD, Green RM, Ziegler SF. Acute blockade of IL-25 in a colitis associated colon cancer model leads to increased tumor burden. Sci Rep. 2016 May 11;6:25643. doi: 10.1038/srep25643. PMID: 27165713

  22. Tran TM, Jones MB, Ongoiba A, Bijker EM, Schats R, Venepally P, Skinner J, Doumbo S, Quinten E, Visser LG, Whalen E, Presnell S, O'Connell EM, Kayentao K, Doumbo OK, Chaussabel D, Lorenzi H, Nutman TB, Ottenhoff TH, Haks MC, Traore B, Kirkness EF, Sauerwein RW, Crompton PD. Transcriptomic evidence for modulation of host inflammatory responses during febrile Plasmodium falciparum malaria. Sci Rep. 2016 Aug 10;6:31291. doi: 10.1038/srep31291. PMID: 27506615

  23. Uchtenhagen H, Rims C, Blahnik G, Chow IT, Kwok WW, Buckner JH, James EA. Efficient ex vivo analysis of CD4+ T-cell responses using combinatorial HLA class II tetramer staining. Nat Commun. 2016 Aug 30;7:12614. doi: 10.1038/ncomms12614. PMID: 27571776

  24. Walker LS, Ziegler SZ, Becher B. Contemplating autoimmunity in the Aegean islands. Nat Immunol. 2016 Mar;17(3):218-20. doi: 10.1038/ni.3367. PMID: 26882250

  25. Ziegler SF. Division of labour by CD4(+) T helper cells. Nat Rev Immunol. 2016 Jul;16(7):403. doi: 10.1038/nri.2016.53. Epub 2016 May 3. PMID: 27140479

October - December

  1. Babon JA, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC. Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes. Nat Med. 2016 Dec;22(12):1482-1487. doi: 10.1038/nm.4203. PMID: 27798614

  2. Balaji S, Wang X, King A, Le LD, Bhattacharya SS, Butte M, Perez VJ, Liechty KW, Wight TN, Crombleholme TM, Bollyky PL, Keswani SG. Interleukin-10-mediated regenerative postnatal tissue repair is dependent on regulation of hyaluronan metabolism via fibroblast-specific STAT3 signaling. FASEB J. 2016 Nov 30. pii: fj.201600856R. PMID: 27903619

  3. Bonifacio E, Mathieu C, Nepom GT, Ziegler AG, Anhalt H, Haller MJ, Harrison LC, Hebrok M, Kushner JA, Norris JM, Peakman M, Powers AC, Todd JA, Atkinson MA. Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity. Diabetologia. 2017 Jan;60(1):35-38. Epub 2016 Oct 26. PMID: 27785529

  4. Cho JL, Ling MF, Adams DC, Faustino L, Islam SA, Afshar R, Griffith JW, Harris RS, Ng A, Radicioni G, Ford AA, Han AK, Xavier R, Kwok WW, Boucher R, Moon JJ, Hamilos DL, Kesimer M, Suter MJ, Medoff BD, Luster AD. Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation. Sci Transl Med. 2016 Oct 5;8(359):359ra132. PMID: 27708065

  5. Dam EM, Habib T, Chen J, Funk A, Glukhova V, Davis-Pickett M, Wei S, James R, Buckner JH, Cerosaletti K. The BANK1 SLE-risk variants are associated with alterations in peripheral B cell signaling and development in humans. Clin Immunol. 2016 Dec;173:171-180. doi: 10.1016/j.clim.2016.10.018. Epub 2016 Nov 2. PMID: 27816669

  6. Gaucherand L, Falk BA, Evanko SP, Workman G, Chan CK, Wight TN. Crosstalk between T Lymphocytes and Lung Fibroblasts: Generation of a Hyaluronan-Enriched Extracellular Matrix Adhesive for Monocytes. J Cell Biochem. 2016 Dec 16. doi: 10.1002/jcb.25842. PMID: 27982477

  7. Gerstner C, Dubnovitsky A, Sandin C, Kozhukh G, Uchtenhagen H, James EA, Rönnelid J, Ytterberg AJ, Pieper J, Reed E, Tandre C, Rieck M, Zubarev RA, Rönnblom L, Sandalova T, Buckner JH, Achour A, Malmström V. Functional and Structural Characterization of a Novel HLA-DRB1*04:01-Restricted α-Enolase T Cell Epitope in Rheumatoid Arthritis. Front Immunol. 2016 Nov 14;7:494. eCollection 2016. PMID: 27895642

  8. Joo S, Fukuyama Y, Park EJ, Yuki Y, Kurashima Y, Ouchida R, Ziegler SF, Kiyono H. Critical role of TSLP-responsive mucosal dendritic cells in the induction of nasal antigen-specific IgA response. Mucosal Immunol. 2016 Dec 7. doi: 10.1038/mi.2016.103. PMID: 27924821

  9. Kang I, Harten IA, Chang MY, Braun KR, Sheih A, Nivison MP, Johnson PY, Workman G, Kaber G, Evanko SP, Chan CK, Merrilees MJ, Ziegler SF, Kinsella MG, Frevert CW, Wight TN. Versican deficiency significantly reduces lung inflammatory response induced by polyinosine-polycytidylic acid stimulation. J Biol Chem. 2016 Nov 28. pii: jbc.M116.753186. PMID: 27895126

  10. Khurana S, Schouteden S, Manesia JK, Santamaria-Martinez A, Huelsken J, Lacy-Hulbert A, Verfaillie CM. Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis. Nat Commun. 2016 Dec 1;7:13500. doi: 10.1038/ncomms13500. PMID: 27905395

  11. Lima SQ, Costa CM, Amemiya CT, Schneider I. Morphological And Molecular Analyses of an Anatomical Novelty: The Pelvic Fin Filaments of the South American Lungfish. J Exp Zool B Mol Dev Evol. 2016 Nov 9. doi: 10.1002/jez.b.22711. PMID: 27862964

  12. Long SA, Thorpe J, DeBerg HA, Gersuk V, Eddy J, Harris KM, Ehlers M, Herold K, Nepom GT, Linsley PS.  Partially exhausted CD8 T cells are associated with clinical response to teplizumab in new-onset type 1 diabetes.  Science Immunology 18 Nov 2016:Vol. 1, Issue 5, DOI: 10.1126/sciimmunol.aai7793.

  13. Michels AW, Landry LG, McDaniel KA, Yu L, Campbell-Thompson M, Kwok WW, Jones KL, Gottlieb PA, Kappler JW, Tang Q, Roep BO, Atkinson MA, Mathews CE, Nakayama M. Islet-derived CD4 T-cells targeting proinsulin in human autoimmune diabetes. Diabetes. 2016 Dec 5. pii: db161025. PMID: 27920090

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