2015 BRI Publications

The following list highlights BRI's publications from 2015. More selective listings of publications are included on scientist biography pages. Featured BRI scientists are listed in bold.

January - March

  1. Archila LD, Jeong D, Pascal M, Bartra J, Juan M, Robinson D, Farrington ML, Kwok WW. Jug r 2-reactive CD4+ T cells have a dominant immune role in walnut allergy. J Allergy Clin Immunol. 2015 Mar 13. pii: S0091-6749(15)00169-4. doi: 10.1016/j.jaci.2015.01.029. PMID: 25772597

  2. Bollyky JB, Xu P, Butte AJ, Wilson DM, Beam CA, Greenbaum CJ; the type 1 Diabetes TrialNet Study Group. Heterogeneity in recent onset type 1 diabetes – a clinical trial perspective. Diabetes Metab Res Rev, 2015 Feb 17, doi: 10.1002/dmrr.2643. PMID: 25689602

  3. Du Toit G, Roberts G, Sayre PH, Bahnson HT, Radulovic S, Santos AF, Brough HA, Phippard D, Basting M, Feeney M, Turcanu V, Sever ML, Gomez Lorenzo M, Plaut M, Lack G; LEAP Study Team. Randomized trial of peanut consumption in infants at risk for peanut allergy. N Engl J Med. 2015 Feb 26;372(9):803-13. doi: 10.1056/NEJMoa1414850. Epub 2015 Feb 23. PMID: 25705822

  4. Gan RW, Deane KD, Zerbe GO, Demoruelle MK, Weisman MH, Buckner JH, Gregersen PK, Mikuls TR, O'Dell JR, Keating RM, Holers VM, Norris JM. Relationship between air pollution and positivity of RA-related autoantibodies in individuals without established RA: a report on SERA. Ann Rheum Dis. 2013 Dec;72(12):2002-5. doi: 10.1136/annrheumdis-2012-202949. Epub 2013 Apr 9. PMID: 23572338

  5. Glatigny S, Duhen R, Arbelaez C, Kumari S, Bettelli E. Integrin alpha L controls the homing of regulatory T cells during CNS autoimmunity in the absence of integrin alpha 4. Sci Rep. 2015 Jan 16;5:7834. doi: 10.1038/srep07834. PMID: 25592296

  6. Gunasekera D, Ettinger RA, Nakaya Fletcher S, James EA, Liu M, Barrett JC, Withycombe J, Matthews DC, Epstein MS, Hughes RJ, Pratt KP. Factor VIII gene variants and inhibitor risk in African American hemophilia A patients. Blood. 2015 Jan 23. pii: blood-2014-09-599365. PMID: 25617427

  7. Hao W, Greenbaum CJ, Krischer JP, Cuthbertson D, Marks JB, Palmer JP. The Effect of DPT-1 Intravenous Insulin Infusion and Daily Subcutaneous Insulin on Endogenous Insulin Secretion and Postprandial Glucose Tolerance. Diabetes Care, 2015 Feb 26, PMID: 25720600

  8. Järveläinen H, Sainio A, Wight TN. Pivotal role for decorin in angiogenesis. Matrix Biol. 2015 Feb 7. pii: S0945-053X(15)00037-2. doi: 10.1016/j.matbio.2015.01.023. PMID: 25661523

  9. Lee HS, Cheerathodi M, Chaki SP, Reyes SB, Zheng Y, Lu Z, DerMardirossian C, Lacy-Hulbert A, Rivera GM, McCarty JH. PTP-PEST and β8 Integrin Control Spatiotemporal Patterns of RhoGDI1 Activation in Migrating Cells. Mol Cell Biol. 2015 Feb 9. pii: MCB.00112-15. PubMed PMID: 25666508.

  10. Lord S, Greenbaum CJ. Disease modifying therapies in type 1 diabetes: Where have we been, and where are we going?. Pharma Res, 2015, March 11. doi:10.1016/j.phrs.2015.02.002. PMID: 25771310

  11. Nagy N, Kuipers HF, Frymoyer AR, Ishak HD, Bollyky JB, Wight TN, Bollyky PL. 4-Methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy in inflammation, autoimmunity, and cancer. Front Immunol. 6:123, 2015. doi: 10.3389/fimmu.2015.00123. PMID: Unknown

  12. Rosenzwajg M, Churlaud G, Mallone R, Six A, Dérian N, Chaara W, Lorenzon R, Long SA, Buckner JH, Afonso G, Pham HP, Hartemann A, Yu A, Pugliese A, Malek TR, Klatzmann D. Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients. J Autoimmun. 2015 Jan 26. pii: S0896-8411(15)00002-5. doi: 10.1016/j.jaut.2015.01.001. PMID: 25634360

  13. Savar A, Acin S, Gonzalez CL, El-Sawy T, Mejia O, Li Z, Esmaeli B, Lacy-Hulbert A, El-Naggar AK, McCarty JH, Caulin C. Loss of epithelial p53 and αv integrin cooperate through Akt to induce squamous cell carcinoma yet prevent remodeling of the tumor microenvironment. Oncogene. 2015 Jan 22;34(4):516-24. doi: 10.1038/onc.2013.585. Epub 2014 Jan 27. PMID: 24469034.

  14. Sosenko JM, Skyler JS, Beam CA, Boulware D, Mahon JL, Krischer JP, Greenbaum CJ, Rafkin LE, Matheson D, Herold KC, Palmer JP; and the Type 1 Diabetes TrialNet and Diabetes Prevention Trial-Type 1 Study Groups. The Development and Utiity of a Novel Scale That Quantifies the Glycemic Progression Toward Type 1 Diabetes Over 6 Months. Diabetes Care, 2015 Mar 10. PMID: 25758770

  15. Sosenko JM, Skyler JS, DiMeglio LA, Beam CA, Krischer JP, Greenbaum CJ, Boulware D, Rafkin LE, Matheson D, Herold KC, Mahon J, Palmer JP; Type 1 Diabetes TrialNet Study Group; Diabetes Prevention trial Type 1 Study Group. A new approach for diagnosing type 1 diabetes in autoantibody-positive individuals based on prediction and natural history. Diabetes Care, 2015 Feb;38(2):271-6 doi: 10.2337/dc14-1813. PMID: 25519451

  16. Tang WJ, Fernandez JG, Sohn JJ, Amemiya CT. Chitin is endogenously produced in vertebrates. Curr Biol. 2015 Mar 30;25(7):897-900. doi: 10.1016/j.cub.2015.01.058. Epub 2015 Mar 12. PMID: 25772447

April - June

  1. Alvarez I, Collado JA, Colobran R, Carrascal M, Ciudad MT, Canals F, James EA, Kwok WW, Gärtner M, Kyewski B, Pujol-Borrell R, Jaraquemada D. Central T cell tolerance: Identification of tissue-restricted autoantigens in the thymus HLA-DR peptidome. J Autoimmun. 2015 Jun;60:12-9. doi: 10.1016/j.jaut.2015.03.004. Epub 2015 Apr 21. PMID: 25911201

  2. Cao Y, Goods BA, Raddassi K, Nepom GT, Kwok WW, Love JC, Hafler DA. Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis. Sci Transl Med. 2015 May 13;7(287):287ra74. doi: 10.1126/scitranslmed.aaa8038. PMID: 25972006

  3. Holgersen K, Kutlu B, Fox B, Serikawa K, Lord J, Hansen AK, Holm TL. High-resolution gene expression profiling using RNA sequencing in patients with inflammatory bowel disease and in mouse models of colitis. J Crohns Colitis. 2015 Jun;9(6):492-506. PMID: 25795566

  4. Kikuchi S, Kenagy RD, Gao L, Wight TN, Azuma N, Sobel M, Clowes AW. Surgical marking pen dye inhibits saphenous vein cell proliferation and migration in saphenous vein graft tissue. J Vasc Surg. 2015 Apr 30. pii: S0741-5214(14)01899-0. doi: 10.1016/j.jvs.2014.10.017. PMID: 25935273

  5. Miller HC, O'Meally D, Ezaz T, Amemiya CT, Marshall-Graves JA, and Edwards S. Major Histocompatibility Complex Genes Map to Two Chromosomes in an Evolutionarily Ancient Reptile, the Tuatara Sphenodon punctatus. G3 (Bethesda). 2015 May 7. pii: g3.115.017467. doi: 10.1534/g3.115.017467. PMID: 25953959

  6. Otsuka F, Kramer MC, Woudstra P, Yahagi K, Ladich E, Finn AV, de Winter RJ, Kolodgie FD, Wight TN, Davis HR, Joner M, Virmani R. Natural progression of atherosclerosis from pathologic intimal thickening to late fibroatheroma in human coronary arteries: A pathology study. Atherosclerosis. 2015 May 19. pii: S0021-9150(15)01312-X. doi: 10.1016/j.atherosclerosis.2015.05.011. PMID: 26058741

  7. Wilson HM, Welikson RE, Luo J, Kean TJ, Cao B, Dennis JE, Allen MD. Can Cytoprotective Cobalt Protoporphyrin Protect Skeletal Muscle and Muscle-derived Stem Cells From Ischemic Injury? Clin Orthop Relat Res. 2015 Jun 13. PMID: 26070773

July - September

  1. Arbelaez CA, Glatigny S, Duhen R, Eberl G, Oukka M, Bettelli E. IL-7/IL-7 Receptor Signaling Differentially Affects Effector CD4+ T Cell Subsets Involved in Experimental Autoimmune Encephalomyelitis. J Immunol. 2015 Sep 1;195(5):1974-83. doi: 10.4049/jimmunol.1403135. Epub 2015 Jul 29. PMID: 26223651

  2. Buechler MB, Gessay GM, Srivastava S, Campbell DJ, Hamerman JA. Hematopoietic and nonhematopoietic cells promote Type I interferon- and TLR7-dependent monocytosis during low-dose LCMV infection. Eur J Immunol. 2015 Aug 19. PMID: 26289159

  3. Eldredge LC, Treuting PM, Manicone AM, Ziegler SF, Parks WC, McGuire JK. CD11b+ Mononuclear Cells Mitigate Hyperoxia-induced Lung Injury in Neonatal Mice. Am J Respir Cell Mol Biol. 2015 Jul 20. [Epub ahead of print] PMID: 26192732

  4. Harten IA, Olive M, Wight TN. Vascular disease in Hutchinson Gilford progeria syndrome and aging: Common phenotypes and potential mechanisms. In: Handbook of the Biology of Aging, Eighth Edition.  Kaeberlein MR, Martin GM eds.  Amsterdam: Elsevier, 2016. PMID: n/a

  5. Hull RL, Bogdani M, Nagy N, Johnson PY, Wight TN. Hyaluronan: A Mediator of Islet Dysfunction and Destruction in Diabetes? J Histochem Cytochem. 2015 Aug;63(8):592-603. doi: 10.1369/0022155415576542. PMID: 26216136

  6. Kang I, Barth JL, Sproul EP, Yoon DW, Braun KR, Argraves WS, Wight TN. Expression of V3 Versican by Rat Arterial Smooth Muscle Cells Promotes Differentiated and Anti-inflammatory Phenotypes. J Biol Chem. 2015 Aug 28;290(35):21629-41. doi: 10.1074/jbc.M115.657486. Epub 2015 Jul 7. PMID: 26152723

  7. Kijas AW, Lim YC, Bolderson E, Cerosaletti K, Gatei M, Jakob B, Tobias F, Taucher-Scholz G, Gueven N, Oakley G, Concannon P, Wolvetang E, Khanna KK, Wiesmüller L, Lavin MF. ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1. Nucleic Acids Res. 2015 Aug 3. pii: gkv754. [Epub ahead of print] PMID: 26240375

  8. Kwok WW. Modulation of Peanut-specific humoral and cellular responses pre- and post-oral immunotherapy. Clin Exp Allergy. 2015 Jul;45(7):1146-9. doi: 10.1111/cea.12552. PMID: 26082305

  9. Linsley PS, Chaussabel D, Speake C. The Relationship of Immune Cell Signatures to Patient Survival Varies within and between Tumor Types. PLoS One. 2015 Sep 23;10(9):e0138726. doi: 10.1371/journal.pone.0138726. eCollection 2015. PubMed PMID: 26398410

  10. Lord JD, Shows DM, Chen J, Thirlby RC. Human Blood and Mucosal Regulatory T Cells Express Activation Markers and Inhibitory Receptors in Inflammatory Bowel Disease. PLoS One. 2015 Aug 25;10(8):e0136485. doi: 10.1371/journal.pone.0136485. eCollection 2015. PMID: 26305224

  11. McGinty JW, Marré ML, Bajzik V, Piganelli JD, James EA. T Cell Epitopes and Post-Translationally Modified Epitopes in Type 1 Diabetes. Curr Diab Rep. 2015 Nov;15(11):90. doi: 10.1007/s11892-015-0657-7. PMID: 26370701

  12. Nagy N, Kaber G, Johnson PY, Gebe JA, Preisinger A, Falk BA, Sunkari VG, Gooden MD, Vernon RB, Bogdani M, Kuipers HF, Day AJ, Campbell DJ, Wight TN, Bollyky PL. Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis. J Clin Invest. 2015 Sep 14. pii: 79271. PMID: 26368307

  13. Rawlings DJ, Dai X, Buckner JH. The role of PTPN22 risk variant in the development of autoimmunity: finding common ground between mouse and human. J Immunol. 2015 Apr 1;194(7):2977-84. doi: 10.4049/jimmunol.1403034. PMID: 25795788

  14. Renand A, Archila LD, McGinty J, Wambre E, Robinson D, Hales BJ, Thomas WR, Kwok WW. Chronic cat allergen exposure induces a TH2 cell-dependent IgG4 response related to low sensitization. J Allergy Clin Immunol. 2015 Sep 11. pii: S0091-6749(15)01091-X. doi: 10.1016/j.jaci.2015.07.031. [Epub ahead of print] PMID: 26371841

  15. Rigby MR, Harris KM, Pinckney A, DiMeglio LA, Rendell MS, Felner EI, Dostou JM, Gitelman SE, Griffin KJ, Tsalikian E, Gottlieb PA, Greenbaum CJ, Sherry NA, Moore WV, Monzavi R, Willi SM, Raskin P, Keyes-Elstein L, Long SA, Kanaparthi S, Lim N, Phippard D, Soppe CL, Fitzgibbon ML, McNamara J, Nepom GT, Ehlers MR, Immune Tolerance Network (ITN). Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients. J Clin Invest. 2015 Aug 3;125(8):3285-96. doi: 10.1172/JCI81722. Epub 2015 Jul 20. PMID: 26193635

  16. Ruppert SM, Falk BA, Long SA, Bollyky PL. Regulatory T cells Resist Cyclosporin-Induced Cell Death Via CD44-mediated Signaling Pathways. International Journal of Cell Biology. vol. 2015, Article ID 614297, 10 pages, 2015. doi:10.1155/2015/614297.

  17. Tacchi L, Larragoite ET, Muñoz P, Amemiya CT, Salinas I. African Lungfish Reveal the Evolutionary Origins of Organized Mucosal Lymphoid Tissue in Vertebrates. Curr Biol. 2015 Sep 2. pii: S0960-9822(15)00934-3. doi: 10.1016/j.cub.2015.07.066. [Epub ahead of print].  PMID: 26344090

  18. Tampella G, Kerns HM, Niu D, Singh S, Khim S, Bosch KA, Garrett ME, Moguche A, Evans E, Browning B, Jahan TA, Nacht M, Wolf-Yadlin A, Plebani A, Hamerman JA, Rawlings DJ, James RG. The Tec Kinase-Regulated Phosphoproteome Reveals a Mechanism for the Regulation of Inhibitory Signals in Murine Macrophages. J Immunol. 2015 Jul 1;195(1):246-56. doi: 10.4049/jimmunol.1403238. Epub 2015 May 29. PMID: 26026062

  19. Tang W, Cui D, Jiang L, Zhao L, Qian W, Long SA, Xu K. Association of common polymorphisms in the IL2RA gene with type 1 diabetes: evidence of 32,646 individuals from 10 independent studies. J Cell Mol Med. 2015 Aug 7. doi: 10.1111/jcmm.12642. [Epub ahead of print]. PMID: 26249556

  20. Zhang M, Yu G, Chan B, Pearson JT, Rathanaswami P, Delaney J, Ching Lim A, Babcook J, Hsu H, Gavin MA. Interleukin-21 Receptor Blockade Inhibits Secondary Humoral Responses and Halts the Progression of Preestablished Disease in the (NZB × NZW)F1 Systemic Lupus Erythematosus Model. Arthritis Rheumatol. 2015 Oct;67(10):2723-31. doi: 10.1002/art.39233. PMID: 26097207

October - December

  1. Bluestone JA, Buckner JH, Fitch M, Gitelman SE, Gupta S, Hellerstein MK, Herold KC, Lares A, Lee MR, Li K, Liu W, Long SA, Masiello LM, Nguyen V, Putnam AL, Rieck M, Sayre PH, Tang Q. Type 1 diabetes immunotherapy using polyclonal regulatory T cells. Sci Transl Med. 2015 Nov 25;7(315):315ra189. PMID: 26606968

  2. Cabrera SM, Wang X, Chen YG, Jia S, Kaldunski ML, Greenbaum CJ; Type 1 Diabetes TrialNet Canakinumab Study Group, Mandrup-Poulsen T; AIDA Study Group, Hessner MJ. Interleukin-1 antagonism moderates the inflammatory state associated with Type 1 diabetes during clinical trials conducted at disease onset. Eur J Immunol, 2015 Dec 22. PMID: 26692253

  3. Chujo D, Nguyen T-S, Foucat E, Blankenship D, Banchereau J, Nepom GT, Chaussabel D, Ueno H. Adult-onset type 1 diabetes patients display decreased IGRP-specific Tr1 cells in blood. Clin Immunol. 2015 Dec;161(2):270-7. doi: 10.1016/j.clim.2015.08.014. PMID: 26341315

  4. Gan RW, Young KA, Zerbe GO, Demoruelle MK, Weisman MH, Buckner JH, Gregersen PK, Mikuls TR, O'Dell JR, Keating RM, Clare-Salzler MJ, Deane KD, Holers VM, Norris JM. Lower omega-3 fatty acids are associated with the presence of anti-cyclic citrullinated peptide autoantibodies in a population at risk for future rheumatoid arthritis: a nested case-control study. Rheumatology (Oxford). 2016 Feb;55(2):367-76. doi: 10.1093/rheumatology/kev266. Epub 2015 Sep 13. PMID: 26370400

  5. Ge Yan, Onengut-Gumuscu S, Quinlan AR, Mackey AJ, Wright JA, Buckner JH, Habib T, Rich SS, Concannon P. Targeted Deep Sequencing in Multiple-Affected Sibships of European Ancestry Identifies Rare Deleterious Variants in PTPN22 that Confer Risk for Type 1 Diabetes. Diabetes. 2015 Dec 2. pii: db150322. [Epub ahead of print]. PMID: 26631741

  6. Gill RG, Pagni PP, Kufper T, Wasserfall CH, Deng S, Posgai A, Manenkova Y, Hani AB, Straub L, Bernstein P, Atkinson MA, Herold KC, von Herrath M, Staeva T, Ehlers MR, Nepom GT. A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice. Diabetes. 2015 Dec 30. pii: db150492. PMID: 26718498

  7. Hamerman JA, Pottle J, Ni M, He Y, Zhang ZY, Buckner JH. Negative regulation of TLR signaling in myeloid cells-implications for autoimmune diseases. Immunol Rev. 2016 Jan;269(1):212-27. doi: 10.1111/imr.12381. PMID: 26683155

  8. Han CY, Tang C, Guevara ME, Wei H, Wietecha T, Shao B, Subramanian S, Omer M, Wang S, O'Brien KD, Marcovina SM, Wight TN, Vaisar T, de Beer MC, de Beer FC, Osborne WR, Elkon KB, Chait A. Serum amyloid A impairs the antiinflammatory properties of HDL. J Clin Invest. 2016 Jan 4;126(1):266-81. doi: 10.1172/JCI83475. Epub 2015 Dec 7. PMID: 26642365

  9. Hinz D, Seumois G, Gholami AM, Greenbaum JA, Lane J, White B, Broide DH, Schulten V, Sidney J, Bakhru P, Oseroff C, Wambre E, James EA, Kwok WW, Peters B, Vijayanand P, Sette A. Lack of allergy to timothy grass pollen is not a passive phenomenon but associated with allergen-specific modulation of immune reactivity. Clin Exp Allergy. 2015 Dec 14. doi: 10.1111/cea.12692. PMID: 26662458

  10. Hu JH, Wei H, Jaffe M, Airhart N, Du L, Angelov SN, Yan J, Allen JK, Kang I, Wight TN, Fox K, Smith A, Enstrom R, Dichek DA. Postnatal Deletion of the Type II Transforming Growth Factor-β Receptor in Smooth Muscle Cells Causes Severe Aortopathy in Mice. Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2647-56. doi: 10.1161/ATVBAHA.115.306573. Epub 2015 Oct 22. PMID: 26494233

  11. Insel RA, Dunne JL, Atkinson MA, Chiang JL, Dabelea D, Gottlieb PA, Greenbaum CJ, Herold KC, Krischer JP, Lernmark Å, Ratner RE, Rewers MJ, Schatz DA, SKlyer JS, Sosenko JM, Ziegler AG. Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association. Diabetes Care, 2015 Oct;38(10):1964-74. Review. PMID: 26404926

  12. Keire PA, Bressler SL, Mulvihill ER, Starcher BC, Kang I, Wight TN. Inhibition of versican expression by siRNA facilitates tropoelastin synthesis and elastic fiber formation by human SK-LMS-1 leiomyosarcoma smooth muscle cells in vitro and in vivo. Matrix Biol. 2015 Dec 23. pii: S0945-053X(15)30013-5. doi: 10.1016/j.matbio.2015.12.010. PMID: 26723257

  13. Lord JD. Promises and paradoxes of regulatory T cells in inflammatory bowel disease. World J Gastroenterol. 2015 Oct 28;21(40):11236-45. doi: 10.3748/wjg.v21.i40.11236. PMID: 26523099

  14. Marré ML, James EA, Piganelli JD. β cell ER stress and the implications for immunogenicity in type 1 diabetes. Front Cell Dev Biol. 2015 Oct 27;3:67. doi: 10.3389/fcell.2015.00067. eCollection 2015. PMID: 26579520

  15. Odegard JM, Nepom GT, and Wambre E. Biomarkers for antigen immunotherapy in allergy and type 1 diabetes. Clin Immunol. 2015 Nov;161(1):44-50. doi: 10.1016/j.clim.2015.05.023. PMID: 26122171

  16. Odegard JM, Nepom GT, Wambre E. Biomarkers for antigen immunotherapy in allergy and type 1 diabetes. Clin Immunol. 2015 Nov;161(1):44-50. doi: 10.1016/j.clim.2015.05.023. PMID: 26122171

  17. Pugliese A, Boulward D, Yu L, Babu S, Steck AK, Becker D, Rodriguez H, DiMeglio L, Evans-Molean C, Harrison LC, Schatz D, Palmer JP, Greenbaum CJ, Eisenbarth GS, Sosenko JM; Type 1 Diabetes TrialNet Study Group. The HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 haplotype protects autoantibody-positive relatives from type 1 diabetes throughout the stages of disease progression. Diabetes, 2016 Jan 28. PMID: 26822082

  18. Stuart LM, Lacy-Hulbert A. De-Mst-ifying microbicidal killing. Nat Immunol. 2015 Oct 20;16(11):1107-8. doi: 10.1038/ni.3291. PMID: 26482969

  19. Wambre E. Effect of allergen-specific immunotherapy on CD4+ T cells. Curr Opin Allergy Clin Immunol. 2015 Dec;15(6):581-7. doi: 10.1097/ACI.0000000000000216. PMID: 26509663