2014 BRI Publications

The following list highlights BRI's publications from 2014. More selective listings of publications are included on scientist biography pages. BRI scientists are listed in bold.

January - March

  1. Amemiya CT. An Ancient Mariner. The Biochemist (Molecular Evolution), Feb;36:23-27.

  2. Chang MY, Tanino Y, Vidova V, Kinsella MG, Chan CK, Johnson PY, Wight TN, Frevert CW. A rapid increase in macrophage-derived versican and hyaluronan in infectious lung disease. Matrix Biol. 2014 Jan 26. pii: S0945-053X(14)00022-5. doi: 10.1016/j.matbio.2014.01.011. PMID: 24472738

  3. Gupta S, Cerosaletti K, Long SA. Renegade homeostatic cytokine responses in T1D: Drivers of regulatory/effector T cell imbalance. Clin Immunol. 2014 Feb 24;151(2):146-154. doi: 10.1016/j.clim.2014.02.007. PMID: 24576418

  4. Handa P, Kowdley KV. Chemokines: potent mediators of hepatic inflammation and fibrosis in chronic liver diseases. Ann Hepatol. 2013 Jan-2014 Feb;13(1):152-4. PMID: 24378280

  5. Khaenam P, Rinchai D, Altman MC, Chiche L, Buddhisa S, Kewcharoenwong C, Suwannasaen D, Mason M, Whalen E, Presnell S, Susaengrat W, O'Brien K, Nguyen QA, Gersuk V, Linsley PS, Lertmemongkolchai G, Chaussabel D. A transcriptomic reporter assay employing neutrophils to measure immunogenic activity of septic patients' plasma. J Transl Med. 2014 Mar 11;12(1):65. doi: 10.1186/1479-5876-12-65. PMID: 24612859

  6. Kowdley KV, Lawitz E, Poordad F, Cohen DE, Nelson DR, Zeuzem S, Everson GT, Kwo P, Foster GR, Sulkowski MS, Xie W, Pilot-Matias T, Liossis G, Larsen L, Khatri A, Podsadecki T, Bernstein B. Phase 2b trial of interferon-free therapy for hepatitis C virus genotype 1. N Engl J Med. 2014 Jan 16;370(3):222-32. doi: 10.1056/NEJMoa1306227. PMID: 24428468

  7. Larson S, Ramsey C, Tinnemore D, Amemiya CT. 2014. Novel Loci Variation and Population Genetics within Leafy Seadragons, Phycodurus eques. Diversity 2014, 6, 33-42; doi:10.3390/d6010033. ISSN 1424-2818

  8. Li S, Rouphael N, Duraisingham S, Romero-Steiner S, Presnell S, Davis C, Schmidt DS, Johnson SE, Milton A, Rajam G, Kasturi S, Carlone GM, Quinn C, Chaussabel D, Palucka AK, Mulligan MJ, Ahmed R, Stephens DS, Nakaya HI, Pulendran B. Molecular signatures of antibody responses derived from a systems biology study of five human vaccines. Nat Immunol. 2014 Feb;15(2):195-204. doi: 10.1038/ni.2789. PMID: 24336226

  9. Mason MJ, Speake C, Gersuk VH, Nguyen QA, O'Brien KK, Odegard JM, Buckner JH, Greenbaum CJ, Chaussabel D, Nepom GT. Low HERV-K(C4) Copy Number is Associated with Type 1 Diabetes. Diabetes. 2014 Jan 15. PMID: 24430436

  10. Robinson M, Amemiya CT. Coelacanths. Curr Biol. 2014 Jan 20;24(2):R62-3. doi: 10.1016/j.cub.2013.10.027. PMID: 24456974

  11. Ruppert SM, Hawn TR, Arrigoni A, Wight TN, Bollyky PL. Tissue integrity signals communicated by high-molecular weight hyaluronan and the resolution of inflammation. Immunol Res. 2014 Mar 11. PMID: 24614953

  12. Saha NR, Ota T, Litman GW, Hansen J, Parra Z, Hsu E, Buonocore F, Canapa A, Cheng JF, Amemiya CT. Genome complexity in the coelacanth is reflected in its adaptive immune system. J Exp Zool B Mol Dev Evol. 2014 Jan 24. doi: 10.1002/jez.b.22558. PMID: 24464682

  13. Savar A, Acin S, Gonzalez CL, El-Sawy T, Mejia O, Li Z, Esmaeli B, Lacy-Hulbert A, El-Naggar AK, McCarty JH, Caulin C. Loss of epithelial p53 and αv integrin cooperate through Akt to induce squamous cell carcinoma yet prevent remodeling of the tumor microenvironment. Oncogene. 2014 Jan 27. doi: 10.1038/onc.2013.585. PMID: 24469034

  14. Sivendran S, Chang R, Pham L, Phelps R, Harcharik S, Hall L, Bernardo S, Moskalenko M, Sivendran M, Fu Y, de Moll EH, Pan M, Moon JY, Arora S, Cohain A, Difeo A, Ferringer T, Tismenetsky M, Tsui C, Friedlander P, Parides M, Banchereau J, Chaussabel D, Lebwohl M, Wolchok J, Bhardwaj N, Burakoff S, Oh W, Palucka K, Merad M, Schadt E, Saenger Y. Dissection of Immune Gene Networks in Primary Melanoma Tumors Critical for Anti-Tumor Surveillance of Patients with Stage II-III Resectable Disease. J Invest Dermatol. 2014 Feb 12. doi: 10.1038/jid.2014.85. PMID: 24522433

  15. Sosenko JM, Skyler JS, Mahon J, Krischer JP, Greenbaum CJ, Rafkin LE, Beam CA, Boulware DC, Matheson D, Cuthbertson D, Herold KC, Eisenbarth G, Palmer JP; the Type 1 Diabetes TrialNet and Diabetes Prevention Trial-Type 1 study Groups. Use of the Diabetes Prevention Trial-Type 1 Risk Score (DPTRS) for Improving the Accuracy of the Risk Classification of Type 1 Diabetes. Diabetes Care. 2014 Apr;37(4):979-84. doi: 10.2337/dc13-2359. Epub 2014 Feb 18. PMID: 24550217

  16. Wight TN, Kang I, Merrilees MJ. Versican and the control of inflammation. Matrix Biol. 2014 Feb 7. pii: S0945-053X(14)00036-5. doi: 10.1016/j.matbio.2014.01.015. PMID: 24513039

  17. Wight TN, Kinsella MG, Evanko SP, Potter-Perigo S, Merrilees MJ. Versican and the regulation of cell phenotype in disease. Biochim Biophys Acta. 2014 Jan 5. pii: S0304-4165(13)00557-6. doi: 10.1016/j.bbagen.2013.12.028. PMID: 24401530

April - June

  1. Afdhal N, Zeuzem S, Kwo P, Chojkier M, Gitlin N, Puoti M, Romero-Gomez M, Zarski JP, Agarwal K, Buggisch P, Foster GR, Bräu N, Buti M, Jacobson IM, Subramanian GM, Ding X, Mo H, Yang JC, Pang PS, Symonds WT, McHutchison JG, Muir AJ, Mangia A, Marcellin P; ION-1 Investigators [Kowdley KV]. Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection. N Engl J Med. 2014 May 15;370(20):1889-98. doi: 10.1056/NEJMoa1402454. Epub 2014 Apr 11. PMID: 24725239

  2. Afkarian M, Hirsch IB, Tuttle KR, Greenbaum C, Himmelfarb J, de Boer IH. Urinary excretion of RAS, BMP, and WNT pathway components in diabetic kidney disease. Physiol Rep, 2014 May 2:2(5):e12010. Doi: 10.14814/phy2.12010 PMID: 24793984

  3. Anderson ML, Nielsen LB, Svensson J, Pörksen S, Haugaard P, Beam C, Greenbaum C, Becker D, Petersen JS, Hansen L, Mortensen HB. Diabetes Progression among 446 children with newly diagnosed type 1 diabetes located in Scandinavia, Europe, and North American during the last 27 years. Pediatr Diabetes, 2013 Nov 25. Doi:10.1111/pedi.12098. PMID: 24731251

  4. Archila LD, DeLong JH, Wambre E, James EA, Robinson DM, Kwok WW. Grass-specific CD4+ T-cells exhibit varying degrees of cross-reactivity, implications for allergen-specific immunotherapy. Clin Exp Allergy. 2014 Apr 8. doi: 10.1111/cea.12324. [Epub ahead of print] PMID: 24708411

  5. Blankley S, Graham CM, Howes A, Bloom CI, Berry MP, Chaussabel D, Pascual V, Banchereau J, Lipman M, O'Garra A. Identification of the key differential transcriptional responses of human whole blood following TLR2 or TLR4 ligation in-vitro. PLoS One. 2014 May 19;9(5):e97702. doi: 10.1371/journal.pone.0097702. eCollection 2014. PMID: 24842522

  6. Bogdani M, Johnson PY, Potter-Perigo S, Nagy N, Day AJ, Bollyky PL, Wight TN. Hyaluronan and Hyaluronan Binding Proteins Accumulate in both Human Type 1 Diabetic Islets and Lymphoid Tissues and Associate with Inflammatory Cells in Insulitis. Diabetes. 2014 Mar 27. [Epub ahead of print] PMID: 24677718

  7. Chaussabel D, Baldwin N. Democratizing systems immunology with modular transcriptional repertoire analyses. Nat Rev Immunol. 2014 Apr;14(4):271-80. doi: 10.1038/nri3642. PMID: 24662387

  8. Chen YG, Cabrera SM, Jia S, Kaldunski ML, Kramer J, Cheong S, Geoffrey R, Roethle MF, Woodliff JE, Greenbaum CJ, Wang X, Hessner MJ. Molecular signatures differentiate immune states in Type 1 Diabetes families. Diabetes, 2014 April 23 [Epub ahead of print] PMID: 24760139

  9. Chiche L, Jourde-Chiche N, Whalen E, Presnell S, Gersuk V, Dang K, Anguiano E, Quinn C, Burtey S, Berland Y, Kaplanski G, Harle JR, Pascual V, Chaussabel D. Modular Transcriptional Repertoire Analyses of Adults With Systemic Lupus Erythematosus Reveal Distinct Type I and Type II Interferon Signatures. Arthritis Rheumatol. 2014 Jun;66(6):1583-95. doi: 10.1002/art.38628. PMID: 24644022

  10. Duhen T, Campbell DJ. IL-1β Promotes the Differentiation of Polyfunctional Human CCR6+CXCR3+ Th1/17 Cells That Are Specific for Pathogenic and Commensal Microbes. J Immunol. 2014 Jul 1;193(1):120-9. doi: 10.4049/jimmunol.1302734. Epub 2014 Jun 2. PMID: 24890729

  11. Durinovic-Belló I, Gersuk VH, Ni C, Wu R, Thorpe J, Jospe N, Sanda S, Greenbaum CJ, Nepom GT. Avidity-Dependent Programming of Autoreactive T Cells in T1D. PLoS One, 2014 May 20;9(5):e98074 doi: 10.1371/journal.pone.0098074. eCollection 2014. PMID: 24844227

  12. Feld JJ, Kowdley KV, Coakley E, Sigal S, Nelson DR, Crawford D, Weiland O, Aguilar H, Xiong J, Pilot-Matias T, DaSilva-Tillmann B, Larsen L, Podsadecki T, Bernstein B. Treatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirin. N Engl J Med. 2014 Apr 24;370(17):1594-603. doi: 10.1056/NEJMoa1315722. Epub 2014 Apr 10. PMID: 24720703

  13. Hauri-Hohl M, Zuklys S, Holländer GA, Ziegler SF. A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla. Nat Immunol. 2014 Jun;15(6):554-61. doi: 10.1038/ni.2869. Epub 2014 Apr 13. PMID: 24728352

  14. James EA, Rieck M, Pieper J, Gebe JA, Yue BB, Tatum M, Peda M, Sandin C, Klareskog L, Malmström V, Buckner JH. Citrulline-specific Th1 cells are increased in rheumatoid arthritis and their frequency is influenced by disease duration and therapy. Arthritis Rheumatol. 2014 Jul;66(7):1712-22. doi: 10.1002/art.38637. PMID: 24665079

  15. Kaneko K, Ito M, Naoe Y, Lacy-Hulbert A, Ikeda K. Integrin αv in the mechanical response of osteoblast lineage cells. Biochem Biophys Res Commun. 2014 May 2;447(2):352-7. doi: 10.1016/j.bbrc.2014.04.006. Epub 2014 Apr 13. PMID: 24726648

  16. Kang I, Yoon DW, Braun KR, Wight TN. Expression of Versican V3 by Arterial Smooth Muscle Cells Alters Tumor Growth Factor β (TGFβ)-, Epidermal Growth Factor (EGF)-, and Nuclear Factor κB (NFκB)-dependent Signaling Pathways, Creating a Microenvironment That Resists Monocyte Adhesion. J Biol Chem. 2014 May 30;289(22):15393-15404. Epub 2014 Apr 9. PMID: 24719328

  17. Kowdley KV, Gordon SC, Reddy KR, Rossaro L, Bernstein DE, Lawitz E, Shiffman ML, Schiff E, Ghalib R, Ryan M, Rustgi V, Chojkier M, Herring R, Di Bisceglie AM, Pockros PJ, Subramanian GM, An D, Svarovskaia E, Hyland RH, Pang PS, Symonds WT, McHutchison JG, Muir AJ, Pound D, Fried MW; ION-3 Investigators. Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosis. N Engl J Med. 2014 May 15;370(20):1879-88. doi: 10.1056/NEJMoa1402355. Epub 2014 Apr 10. PMID: 24720702

  18. Kowdley KV. Advances in the diagnosis and treatment of nonalcoholic steatohepatitis. Gastroenterol Hepatol (N Y). 2014 Mar;10(3):184-6. PMID: 24829546

  19. Kratz M, Marcovina S, Nelson JE, Yeh MM, Kowdley KV, Callahan HS, Song X, Di C, Utzschneider KM. Dairy fat intake is associated with glucose tolerance, hepatic and systemic insulin sensitivity, and liver fat but not β-cell function in humans. Am J Clin Nutr. 2014 Apr 16;99(6):1385-1396. [Epub ahead of print]. PMID: 24740208

  20. Lammers WJ, Kowdley KV, van Buuren HR. Predicting outcome in primary biliary cirrhosis. Ann Hepatol. 2014 Jul-Aug;13(4):316-26. PMID: 24927602

  21. Luo J, Weaver MS, Cao B, Dennis JE, Van Biber B, Laflamme MA, Allen MD. Cobalt protoporphyrin pretreatment protects human embryonic stem cell-derived cardiomyocytes from hypoxia/reoxygenation injury in vitro and increases graft size and vascularization in vivo. Stem Cells Transl Med. 2014 Jun;3(6):734-44. doi: 10.5966/sctm.2013-0189. Epub 2014 Apr 15. PMID: 24736402

  22. McGinty JW, Chow IT, Greenbaum C, Odegard J, Kwok WW, James EA. Recognition of post-translationally modified glutamic acid decarboxylase 65 epitopes in subjects with type 1 diabetes. Diabetes, 2014 April 4 [Epub ahead of print]. PMID: 24705406

  23. Merrilees MJ, Falk BA, Zuo N, Dickinson ME, May BC, Wight TN. Use of versican variant V3 and versican antisense expression to engineer cultured human skin containing increased content of insoluble elastin. J Tissue Eng Regen Med. 2014 Jun 19. doi: 10.1002/term.1913. [Epub ahead of print] PMID: 24945362

  24. Nemeth CL, Janebodin K, Yuan AE, Dennis JE, Reyes M, Kim DH. Enhanced Chondrogenic Differentiation of Dental Pulp Stem Cells Using Nanopatterned PEG-GelMA-HA Hydrogels. Tissue Eng Part A. 2014 Jun 30. [Epub ahead of print] PMID: 24749806

  25. Poordad F, Hezode C, Trinh R, Kowdley KV, Zeuzem S, Agarwal K, Shiffman ML, Wedemeyer H, Berg T, Yoshida EM, Forns X, Lovell SS, Da Silva-Tillmann B, Collins CA, Campbell AL, Podsadecki T, Bernstein B. ABT-450/r-ombitasvir and dasabuvir with ribavirin for hepatitis C with cirrhosis. N Engl J Med. 2014 May 22;370(21):1973-82. doi: 10.1056/NEJMoa1402869. Epub 2014 Apr 11. PMID: 24725237

  26. Ramsdell F, Ziegler SF. FOXP3 and scurfy: how it all began. Nat Rev Immunol. 2014 May;14(5):343-9. doi: 10.1038/nri3650. Epub 2014 Apr 11. PMID: 24722479

  27. Reeves SR, Kolstad T, Lien TY, Elliott M, Ziegler SF, Wight TN, Debley JS. Asthmatic airway epithelial cells differentially regulate fibroblast expression of extracellular matrix components. J Allergy Clin Immunol. 2014 May 26. pii: S0091-6749(14)00568-5. doi: 10.1016/j.jaci.2014.04.007. [Epub ahead of print] PMID: 24875618

  28. Smigiel KS, Srivastava S, Stolley JM, Campbell DJ. Regulatory T-cell homeostasis: steady-state maintenance and modulation during inflammation. Immunol Rev. 2014 May;259(1):40-59. doi: 10.1111/imr.12170. PMID: 24712458

  29. Smilek DE, Ehlers MR, Nepom GT. Restoring the balance: immunotherapeutic combinations for autoimmune disease. Dis Model Mech. 2014 May;7(5):503-13. doi: 10.1242/dmm.015099. PMID: 24795433

  30. Srivastava S, Koch MA, Pepper M, Campbell DJ. Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection. J Exp Med. 2014 May 5;211(5):961-74. doi: 10.1084/jem.20131556. Epub 2014 Apr 7. PMID: 24711580

  31. Tam JM, Mansour MK, Khan NS, Seward M, Puranam S, Tanne A, Sokolovska A, Becker CE, Acharya M, Baird MA, Choi AM, Davidson MW, Segal BH, Lacy-Hulbert A, Stuart LM, Xavier RJ, Vyas JM. Dectin-1-Dependent LC3 Recruitment to Phagosomes Enhances Fungicidal Activity in Macrophages. J Infect Dis. 2014 May 19. pii: jiu290. [Epub ahead of print] PMID: 24842831

  32. Tsang JS, Schwartzberg PL, Kotliarov Y, Biancotto A, Xie Z, Germain RN, Wang E, Olnes MJ, Narayanan M, Golding H, Moir S, Dickler HB, Perl S, Cheung F; Baylor HIPC Center; CHI Consortium [Chaussabel D]. Global analyses of human immune variation reveal baseline predictors of postvaccination responses. Cell. 2014 Apr 10;157(2):499-513. doi: 10.1016/j.cell.2014.03.031. PMID: 24725414

  33. VanBuecken DE, Greenbaum CJ. Residual C-peptide in type 1 diabetes: what do we really know? Pediatr Diabetes, 2014 Mar;15(2):84-90. Doi:10.1111/pedi.12135. PMID: 24645775

July - September

  1. Amemiya CT, Dorrington R, Meyer A. The coelacanth and its genome. J Exp Zool B Mol Dev Evol. 2014 Sep;322(6):317-21. doi: 10.1002/jez.b.22583. Epub 2014 Jul 25. PMID: 25059403

  2. Brawand D, Wagner CE, Li YI, Malinsky M, Keller I, Fan S, Simakov O, Ng AY, Lim ZW, Bezault E, Turner-Maier J, Johnson J, Alcazar R, Noh HJ, Russell P, Aken B, Alföldi J, Amemiya CT, Azzouzi N, Baroiller JF, Barloy-Hubler F, Berlin A, Bloomquist R, Carleton KL, Conte MA, D'Cotta H, Eshel O, Gaffney L, Galibert F, Gante HF, Gnerre S, Greuter L, Guyon R, Haddad NS, Haerty W, Harris RM, Hofmann HA, Hourlier T, Hulata G, Jaffe DB, Lara M, Lee AP, MacCallum I, Mwaiko S, Nikaido M, Nishihara H, Ozouf-Costaz C, Penman DJ, Przybylski D, Rakotomanga M, Renn SC, Ribeiro FJ, Ron M, Salzburger W, Sanchez-Pulido L, Santos ME, Searle S, Sharpe T, Swofford R, Tan FJ, Williams L, Young S, Yin S, Okada N, Kocher TD, Miska EA, Lander ES, Venkatesh B, Fernald RD, Meyer A, Ponting CP, Streelman JT, Lindblad-Toh K, Seehausen O, Di Palma F. The genomic substrate for adaptive radiation in African cichlid fish. Nature. 2014 Sep 18;513(7518):375-81. doi: 10.1038/nature13726. Epub 2014 Sep 3. PMID: 25186727

  3. Chang MY, Tanino Y, Vidova V, Kinsella MG, Chan CK, Johnson PY, Wight TN, Frevert CW. Reprint of: A rapid increase in macrophage-derived versican and hyaluronan in infectious lung disease. Matrix Biol. 2014 Apr;35:162-73. doi: 10.1016/j.matbio.2014.04.003. Epub 2014 Apr 12. PMID: 24727035

  4. Chen X, Bracht JR, Goldman AD, Dolzhenko E, Clay DM, Swart EC, Perlman DH, Doak TG, Stuart A, Amemiya CT, Sebra RP, Landweber LF. The architecture of a scrambled genome reveals massive levels of genomic rearrangement during development. Cell. 2014 Aug 28;158(5):1187-98. doi: 10.1016/j.cell.2014.07.034. PMID: 25171416

  5. Damodarasamy M, Johnson RS, Bentov I, MacCoss MJ, Vernon RB, Reed MJ. Hyaluronan enhances wound repair and increases collagen III in aged dermal wounds. Wound Repair Regen. 2014 Jul-Aug;22(4):521-6. doi: 10.1111/wrr.12192. PMID: 25041621

  6. Damodarasamy M, Vernon RB, Chan CK, Plymate SR, Wight TN, Reed MJ. Hyaluronan in aged collagen matrix increases prostate epithelial cell proliferation. In Vitro Cell Dev Biol Anim. 2014 Aug 15. PMID: 25124870

  7. Ghany MG, Perrillo R, Li R, Belle SH, Janssen HL, Terrault NA, Shuhart MC, Lau DT, Kim WR, Fried MW, Sterling RK, Di Bisceglie AM, Han SH, Ganova-Raeva LM, Chang KM, Lok AS; Hepatitis B Research Network [Kowdley KV]. Characteristics of Adults in the Hepatitis B Research Network in North America Reflect Their Country of Origin and Hepatitis B Virus Genotype. Clin Gastroenterol Hepatol. 2014 Jul 8. pii: S1542-3565(14)00976-8. doi: 10.1016/j.cgh.2014.06.028.  PMID: 25010003

  8. Iijima K, Kobayashi T, Hara K, Kephart GM, Ziegler SF, McKenzie AN, Kita H. IL-33 and thymic stromal lymphopoietin mediate immune pathology in response to chronic airborne allergen exposure. J Immunol. 2014 Aug 15;193(4):1549-59. doi: 10.4049/jimmunol.1302984. Epub 2014 Jul 11. PMID: 25015831

  9. Kawasaki K, Amemiya CT. SCPP Genes in the Coelacanth: Tissue mineralization genes shared by sarcopterygians. J Exp Zool B Mol Dev Evol. 2014 Sep;322(6):390-402. PMID: 25243252

  10. Kurmaeva E, Lord JD, Zhang S, Bao JR, Kevil CG, Grisham MB, Ostanin DV. T cell-associated α4β7 but not α4β1 integrin is required for the induction and perpetuation of chronic colitis. Mucosal Immunol. 2014 Apr 9. doi: 10.1038/mi.2014.22. PMID: 24717354 (Not Previously Reported)

  11. Lammers WJ, van Buuren HR, Hirschfield GM, Janssen HL, Invernizzi P, Mason AL, Ponsioen CY, Floreani A, Corpechot C, Mayo MJ, Battezzati PM, Parés A, Nevens F, Burroughs AK, Kowdley KV, Trivedi PJ, Kumagi T, Cheung A, Lleo A, Imam MH, Boonstra K, Cazzagon N, Franceschet I, Poupon R, Caballeria L, Pieri G, Kanwar PS, Lindor KD, Hansen BE; Global PBC Study Group. Levels of Alkaline Phosphatase and Bilirubin Are Surrogate End Points of Outcomes of Patients With Primary Biliary Cirrhosis: An International Follow-up Study. Gastroenterology. 2014 Aug 23. pii: S0016-5085(14)01040-3. doi: 10.1053/j.gastro.2014.08.029.  PMID: 25160979

  12. Linsley PS, Speake C, Whalen E, Chaussabel D. Copy number loss of the interferon gene cluster in melanomas is linked to reduced T cell infiltrate and poor patient prognosis. PLoS One. 2014 Oct 14;9(10):e109760. doi: 10.1371/journal.pone.0109760. eCollection 2014. PMID: 25314013

  13. McGinty JW, Chow IT, Greenbaum CJ, Odegard J, Kwok WW, James EA. Recognition of posttranslationally modified GAD65 epitopes in subjects with type 1 diabetes. Diabetes. 2014 Sep;63(9):3033-40. doi: 10.2337/db13-1952. Epub 2014 Apr 4. PMID: 24705406

  14. Muir AJ, Arora S, Everson G, Flisiak R, George J, Ghalib R, Gordon SC, Gray T, Greenbloom S, Hassanein T, Hillson J, Horga MA, Jacobson IM, Jeffers L, Kowdley KV, Lawitz E, Lueth S, Rodriguez-Torres M, Rustgi V, Shemanski L, Shiffman ML, Srinivasan S, Vargas HE, Vierling JM, Xu D, Lopez-Talavera JC, Zeuzem S; EMERGE study group. A randomized phase 2b study of peginterferon lambda-1a for the treatment of chronic HCV infection. J Hepatol. 2014 Jul 24. pii: S0168-8278(14)00521-2. doi: 10.1016/j.jhep.2014.07.022.  PMID: 25064437

  15. Muto T, Fukuoka A, Kabashima K, Ziegler SF, Nakanishi K, Matsushita K, Yoshimoto T. The role of basophils and proallergic cytokines, TSLP and IL-33, in cutaneously sensitized food allergy. Int Immunol. 2014 Oct;26(10):539-49. doi: 10.1093/intimm/dxu058. Epub 2014 May 22. PMID: 24860117

  16. Pugliese A, Vendrame F, Reijonen H, Atkinson MA, Campbell-Thompson M, Burke GW. New insight on human type 1 diabetes biology: nPOD and nPOD-transplantation. Curr Diab Rep. 2014 Oct;14(10):530. doi: 10.1007/s11892-014-0530-0. PMID: 25142715

  17. Renand A, Newbrough S, Wambre E, DeLong JH, Robinson D, Kwok WW. Arginine kinase Pen m 2 as an important shrimp allergen recognized by TH2 cells. J Allergy Clin Immunol. 2014 Sep 12. pii: S0091-6749(14)01052-5. doi: 10.1016/j.jaci.2014.07.048. PMID: 25224098

  18. Singh AK, Eken A, Fry M, Bettelli E, Oukka M. DOCK8 regulates protective immunity by controlling the function and survival of RORγt+ ILCs. Nat Commun. 2014 Aug 5;5:4603. doi: 10.1038/ncomms5603. PMID: 25091235

  19. Srivastava S, Koch LK, Campbell DJ. IFNαR Signaling in Effector but Not Regulatory T Cells Is Required for Immune Dysregulation during Type I IFN-Dependent Inflammatory Disease. J Immunol. 2014 Sep 15;193(6):2733-42. doi: 10.4049/jimmunol.1401039. Epub 2014 Aug 4. PMID: 25092894

  20. Yang J, Chow IT, Sosinowski T, Torres-Chinn N, Greenbaum CJ, James EA, Kappler JW, Davidson HW, Kwok WW. Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes. Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14840-5. doi: 10.1073/pnas.1416864111. Epub 2014 Sep 29. PMID: 25267644

October - December

  1. Antonacci F, Dennis MY, Huddleston J, Sudmant PH, Steinberg KM, Rosenfeld JA, Miroballo M, Graves TA, Vives L, Malig M, Denman L, Raja A, Stuart A, Tang J, Munson B, Shaffer LG, Amemiya CT, Wilson RK, Eichler EE. Palindromic GOLGA8 core duplicons promote chromosome 15q13.3 microdeletion and evolutionary instability. Nat Genet. 2014 Dec;46(12):1293-302. doi: 10.1038/ng.3120. PMID: 25326701

  2. Bogdani M, Korpos E, Simeonovic CJ, Parish CR, Sorokin L, Wight TN. Extracellular matrix components in the pathogenesis of type 1 diabetes. Curr Diab Rep. 2014 Dec;14(12):552. doi: 10.1007/s11892-014-0552-7. PMID: 25344787

  3. Bogdani M, Simeonovic C, Nagy N, Johnson PY, Chan CK, Wight TN. The detection of glycosaminoglycans in pancreatic islets and lymphoid tissues. Methods Mol Biol. 2015;1229:413-30. doi: 10.1007/978-1-4939-1714-3_32. PMID: 25325969

  4. Chow IT, Yang J, Gates TJ, James EA, Mai DT, Greenbaum C, Kwok WW. Assessment of CD4+ T cell responses to glutamic acid decarboxylase 65 using DQ8 tetramers reveals a pathogenic role of GAD65 121-140 and GAD65 250-266 in T1D development. PLoS One. 2014 Nov 18;9(11):e112882. doi: 10.1371/journal.pone.0112882. eCollection 2014. PMID: 25405480

  5. Davis AK, DuBose SN, Haller MJ, Miller KM, DiMeglio LA, Bethin KE, Goland RS, Greenberg EM, Liljenquist DR, Ahmann AJ, Marcovina SM, Peters AL, Beck RW, Greenbaum CJ; for the T1D Exchange Clinic Network. Prevalence of Detectable C-peptide According to Age at Diagnosis and Duration of Type 1 Diabetes. Diabetes Care. 2014 Dec 17. pii: DC_141952. PMID: 25519448

  6. Evanko SP, Potter-Perigo S, Petty LJ, Workman GA, Wight TN. Hyaluronan Controls the Deposition of Fibronectin and Collagen and Modulates TGF-β1 Induction of Lung Myofibroblasts. Matrix Biol. 2014 Dec 27. pii: S0945-053X(14)00222-4. doi: 10.1016/j.matbio.2014.12.001. PMID: 25549589

  7. Han H, Thelen TD, Comeau MR, Ziegler SF. Thymic stromal lymphopoietin-mediated epicutaneous inflammation promotes acute diarrhea and anaphylaxis. J Clin Invest. 2014 Dec 1;124(12):5442-52. doi: 10.1172/JCI77798. Epub 2014 Nov 3. PMID: 25365222

  8. Keire PA, Bressler SL, Lemire JM, Edris B, Rubin BP, Rahmani M, McManus BM, van de Rijn M, Wight TN. A role for versican in the development of leiomyosarcoma. J Biol Chem. 2014 Dec 5;289(49):34089-103. doi: 10.1074/jbc.M114.607168. Epub 2014 Oct 15. PMID: 25320080

  9. Lo Kuan E, Ziegler SF. Thymic stromal lymphopoietin and cancer. J Immunol. 2014 Nov 1;193(9):4283-8. doi: 10.4049/jimmunol.1400864. PMID: 25326546

  10. Lord J, Chen J, Thirlby RC, Sherwood AM, Carlson CS. T-cell Receptor Sequencing Reveals the Clonal Diversity and Overlap of Colonic Effector and FOXP3+ T Cells in Ulcerative Colitis. Inflamm Bowel Dis. 2015 Jan;21(1):19-30. doi: 10.1097/MIB.0000000000000242. PMID: 25437819

  11. Mikacenic C, Schneider A, Radella F, Buckner JH, Wurfel MM. Cutting Edge: Genetic Variation in TLR1 Is Associated with Pam3CSK4-Induced Effector T Cell Resistance to Regulatory T Cell Suppression. J Immunol. 2014 Dec 15;193(12):5786-90. doi: 10.4049/jimmunol.1401185. Epub 2014 Nov 5. PMID: 25378593

  12. Peters A, Burkett PR, Sobel RA, Buckley CD, Watson SP, Bettelli E, Kuchroo VK. Podoplanin negatively regulates CD4+ effector T cell responses. J Clin Invest. 2014 Nov 21. pii: 74685. doi: 10.1172/JCI74685. PMID: 25415436