2013 BRI Publications

The following list highlights BRI's publications from 2013 (also December 2012). More selective listings of publications are included on scientist biography pages. Featured BRI scientists are listed in bold.

December - February 2013

  1. Bell BD, Kitajima M, Larson RP, Stoklasek TA, Dang K, Sakamoto K, Wagner KU, Reizis B, Hennighausen L, Ziegler SF. The transcription factor STAT5 is critical in dendritic cells for the development of T(H)2 but not T(H)1 responses. Nat Immunol. 2013 Feb 24. doi: 10.1038/ni.2541. [Epub ahead of print] PMID: 23435120

  2. Bonvalet M, Moussu H, Wambre E, Ricarte C, Horiot S, Rimaniol AC, Kwok WW, Horak F, de Beaumont O, Baron-Bodo V, Moingeon P. Allergen-specific CD4(+) T cell responses in peripheral blood do not predict the early onset of clinical efficacy during grass pollen sublingual immunotherapy. Clin Exp Allergy. 2012 Dec;42(12):1745-55. doi: 10.1111/cea.12015. PMID: 23181790

  3. Boyd A, Bennuru S, Wang Y, Sanprasert V, Law M, Chaussabel D, Nutman TB, Semnani RT. Quiescent Innate Response to Infective Filariae by Human Langerhans Cells Suggests a Strategy of Immune Evasion. Infect Immun. 2013 Feb 19. [Epub ahead of print] PMID: 23429540

  4. Buechler MB, Teal TH, Elkon KB, Hamerman JA. Cutting edge: Type I IFN drives emergency myelopoiesis and peripheral myeloid expansion during chronic TLR7 signaling. J Immunol. 2013 Feb 1;190(3):886-91. doi: 10.4049/jimmunol.1202739. Epub 2013 Jan 9. PMID: 23303674

  5. Chau JP, Chung LC, Wong RY, Loo KM, Lo SH, So TT, Lau MS, Yeung TH, Leung BS, Tong ML, Li CY, Kwok WW, Thompson DR, Lee DT. An Evaluation of a Web-Based Diabetes Education Program Designed to Enhance Self-management Among Patients Living With Diabetes. Comput Inform Nurs. 2012 Dec;30(12):672-679. PMID: 22872044

  6. Chujo D, Foucat E, Nguyen TS, Chaussabel D, Banchereau J, Ueno H. ZnT8-Specific CD4(+) T Cells Display Distinct Cytokine Expression Profiles between Type 1 Diabetes Patients and Healthy Adults. PLoS One. 2013;8(2):e55595. doi: 10.1371/journal.pone.0055595. PMID: 23390544

  7. Corn DJ, Kim Y, Krebs MD, Mounts T, Molter J, Gerson S, Alsberg E, Dennis JE, Lee Z. Imaging Early Stage Osteogenic Differentiation of Mesenchymal Stem Cells. J Orthop Res. 2013 Feb 25. doi: 10.1002/jor.22328. [Epub ahead of print] PMID: 23440976

  8. Dunn W, Sanyal AJ, Brunt EM, Unalp-Arida A, Donohue M, McCullough AJ, and Schwimmer JB; for the Nonalcoholic Steatohepatitis Clinical Research Network [Kowdley KV, Nelson JE]. Modest alcohol consumption is associated with decreased prevalence of steatohepatitis in patients with nonalcoholic fatty liver disease (NAFLD). J Hepatol 2012 Aug;57(2):384-91. PMID: 22521357

  9. Greenbaum CJ, Schatz DA, Haller MJ, Sanda S. Response to Comment on: Greenbaum et al. Through the Fog: Recent Clinical Trials to Preserve Beta-Cell Function in Type 1 Diabetes. Diabetes 2012;61:1323-1330. Diabetes. 2012 Dec;61(12):e19. doi: 10.2337/db12-0914. PMID: 23172965

  10. Guerrerio AL, Colvin RM, Schwartz AK, Molleston JP, Murray KF, Diehl A, Mohan P, Schwimmer JB, Lavine JE, Torbenson MS, Scheimann AO; for the NASH CRN [Kowdley KV, Nelson JE]. Choline intake in a large cohort of patients with nonalcoholic fatty liver disease. Am J Clin Nutr, 2012 Apr;95(4):892-900. PMID: 22338037 (not previously reported in 2012)

  11. Han H, Headley MB, Xu W, Comeau MR, Zhou B, Ziegler SF. Thymic Stromal Lymphopoietin Amplifies the Differentiation of Alternatively Activated Macrophages. J Immunol. 2012 Dec 28. [Epub ahead of print] PMID: 23275605

  12. Jhingran A, Mar KB, Kumasaka DK, Knoblaugh SE, Ngo LY, Segal BH, Iwakura Y, Lowell CA, Hamerman JA, Lin X, Hohl TM. Tracing conidial fate and measuring host cell antifungal activity using a reporter of microbial viability in the lung. Cell Rep. 2012 Dec 27;2(6):1762-73. doi: 10.1016/j.celrep.2012.10.026. Epub 2012 Nov 29. PMID: 23200858

  13. Kong XF, Vogt G, Itan Y, Macura-Biegun A, Szaflarska A, Kowalczyk D, Chapgier A, Abhyankar A, Furthner D, Djambas Khayat C, Okada S, Bryant VL, Bogunovic D, Kreins A, Moncada-Vélez M, Migaud M, Al-Ajaji S, Al-Muhsen S, Holland SM, Abel L, Picard C, Chaussabel D, Bustamante J, Casanova JL, Boisson-Dupuis S. Haploinsufficiency at the human IFNGR2 locus contributes to mycobacterial disease. Hum Mol Genet. 2012 Nov 30. [Epub ahead of print] PMID: 23161749

  14. Lawitz E, Poordad F, Kowdley KV, Cohen DE, Podsadecki T, Siggelkow S, Larsen L, Menon R, Koev G, Tripathi R, Pilot-Matias T, Bernstein B. A Phase 2a Trial of 12-Week Interferon-Free Therapy with Two Direct-Acting Antivirals (ABT-450/r, ABT-072) and Ribavirin in IL28B C/C Patients with Chronic Hepatitis C Genotype 1. J Hepatol. 2013 Feb 21. doi:pii: S0168-8278(13)00131-1. 10.1016/j.jhep.2013.02.009. [Epub ahead of print]. PMID: 23439262

  15. Li Y, Kowdley KV. MicroRNAs in Common Human Diseases. Genomics Proteomics Bioinformatics. 2012 Oct;10(5):246-53. doi: 10.1016/j.gpb.2012.07.005. Epub 2012 Sep 29. PMID: 23200134

  16. Lindestam Arlehamn CS, Gerasimova A, Mele F, Henderson R, Swann J, Greenbaum JA, Kim Y, Sidney J, James EA, Taplitz R, McKinney DM, Kwok WW, Grey H, Sallusto F, Peters B, Sette A. Memory T Cells in Latent Mycobacterium tuberculosis Infection Are Directed against Three Antigenic Islands and Largely Contained in a CXCR3(+)CCR6(+) Th1 Subset. PLoS Pathog. 2013 Jan;9(1):e1003130. doi: 10.1371/journal.ppat.1003130. Epub 2013 Jan 24. PMID: 23358848

  17. Loomba R, Abraham M, Unalp A, Wilson L, Lavine J, Doo E, Bass NM; Nonalcoholic Steatohepatitis Clinical Research Network [Kowdley KVNelson JE]. Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis. Hepatology. 2012 Sep;56(3):943-51. doi: 10.1002/hep.25772. Epub 2012 Jul 26. PMID: 22505194

  18. Maahs DM, Dabelea D, D'Agostino RB Jr, Andrews JS, Shah AS, Crimmins N, Mayer-Davis EJ, Marcovina S, Imperatore G, Wadwa RP, Daniels SR, Reynolds K, Hamman RF, Dolan LM; SEARCH for Diabetes in Youth Study [Greenbaum CJ]. Glucose control predicts 2-year change in lipid profile in youth withType 1 diabetes. J Pediatr. 2013 Jan;162(1):101-7.e1. doi: 10.1016/j.jpeds.2012.06.006. PMID: 22795314

  19. Maliken BD, Nelson JE, Klintworth HM, Beauchamp M, Yeh MM, Kowdley KV. Hepatic reticuloendothelial system cell iron deposition is associated with increased apoptosis in nonalcoholic fatty liver disease. Hepatology. 2013 Jan 16. doi: 10.1002/hep.26238. [Epub ahead of print] PMID: 23325576

  20. Matthis J, Reijonen H. Production of primary human CD4^(+) T cell lines and clones. Methods Mol Biol. 2013;960:545-55. doi: 10.1007/978-1-62703-218-6_40. PMID: 23329513

  21. Plumb AW, Patton DT, Seo JH, Loveday EK, Jean F, Ziegler SF, Abraham N. Interleukin-7, but not thymic stromal lymphopoietin, plays a key role in the T cell response to influenza a virus. PLoS One. 2012;7(11):e50199. doi: 10.1371/journal.pone.0050199. Epub 2012 Nov 26. PMID: 23189186

  22. Poordad F, Lawitz E, Kowdley KV, Cohen DE, Podsadecki T, Siggelkow S, Heckaman M, Larsen L, Menon R, Koev G, Tripathi R, Pilot-Matias T, Bernstein B. Exploratory study of oral combination antiviral therapy for hepatitis C. N Engl J Med. 2013 Jan 3;368(1):45-53. doi: 10.1056/NEJMoa1208809. PMID: 23281975

  23. Rabinowitz KM, Wang Y, Chen E, Hovhannisyan Z, Chiang D, Berin MC, Dahan S, Chaussabel D, Ma'ayan A, Mayer L. Transforming Growth Factor-b Signaling Controls Activities of Human Intestinal CD8+ T Suppressor Cells. Gastroenterology. 2012 Dec 8. doi:pii: S0016-5085(12)01744-1. 10.1053/j.gastro.2012.12.001. [Epub ahead of print] PMID: 23232296

  24. Rodriguez-Torres M, Lawitz E, Kowdley KV, Nelson DR, Dejesus E, McHutchison JG, Cornpropst MT, Mader M, Albanis E, Jiang D, Hebner CM, Symonds WT, Berrey MM, Lalezari J. Sofosbuvir (GS-7977) plus peginterferon/ribavirin in treatment-naïve patients with HCV genotype 1: a randomized, 28-day, dose-ranging trial. J Hepatol. 2012 Nov 23. doi:pii: S0168-8278(12)00887-2. 10.1016/j.jhep.2012.11.018. [Epub ahead of print] PMID: 23183528

  25. Sarikonda G, Sachithanantham S, Manenkova Y, Kupfer T, Posgai A, Wasserfall C, Bernstein P, Straub L, Pagni PP, Schneider D, Calvo TR, Coulombe M, Herold K, Gill RG, Atkinson M, Nepom GT, Ehlers M, Staeva T, Garren H, Steinman L, Chan AC, von Herrath M. Transient B-Cell Depletion with Anti-CD20 in Combination with Proinsulin DNA Vaccine or Oral Insulin: Immunologic Effects and Efficacy in NOD Mice. PLoS One. 2013;8(2):e54712. doi: 10.1371/journal.pone.0054712. Epub 2013 Feb 6. PMID: 23405091

  26. Schneider A, Long SA, Cerosaletti K, Ni CT, Samuels P, Kita M, Buckner JH. In Active Relapsing-Remitting Multiple Sclerosis, Effector T Cell Resistance to Adaptive Tregs Involves IL-6-Mediated Signaling. Sci Transl Med. 2013 Jan 30;5(170):170ra15. doi: 10.1126/scitranslmed.3004970. PMID: 23363979

  27. Smith JJ, Kuraku S, Holt C, Sauka-Spengler T, Jiang N, Campbell MS, Yandell MD, Manousaki T, Meyer A, Bloom OE, Morgan JR, Buxbaum JD, Sachidanandam R, Sims C, Garruss AS, Cook M, Krumlauf R, Wiedemann LM, Sower SA, Decatur WA, Hall JA, Amemiya CT, Saha NR, Buckley KM, Rast JP, Das S, Hirano M, McCurley N, Guo P, Rohner N, Tabin CJ, Piccinelli P, Elgar G, Ruffier M, Aken BL, Searle SM, Muffato M, Pignatelli M, Herrero J, Jones M, Brown CT, Chung-Davidson YW, Nanlohy KG, Libants SV, Yeh CY, McCauley DW, Langeland JA, Pancer Z, Fritzsch B, de Jong PJ, Zhu B, Fulton LL, Theising B, Flicek P, Bronner ME, Warren WC, Clifton SW, Wilson RK, Li W. Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution. Nat Genet. 2013 Feb 24. doi: 10.1038/ng.2568. [Epub ahead of print] PMID: 23435085

  28. Sun X, Wiedeman A, Agrawal N, Teal TH, Tanaka L, Hudkins KL, Alpers CE, Bolland S, Buechler MB, Hamerman JA, Ledbetter JA, Liggitt D, Elkon KB. Increased RNase Expression Reduces Inflammation and Prolongs Survival in TLR7 Transgenic Mice. J Immunol. 2013 Feb 4. [Epub ahead of print] PMID: 23382559

  29. Suzuki A, Abdelmalek MF, Schwimmer JB, Lavine JE, Scheimann A, Unalp-Arida A, Yates KP, Sanyal AJ, Guy CD, Diehl AM; for the NASH CRN [Kowdley KV, Nelson JE]. Association between puberty and features of nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2012 Jul;10(7):786-94. PMID: 22343513 (not previously reported in 2012)

  30. Tzelepis F, Joseph J, Haddad EK, Maclean S, Dudani R, Agenes F, Peng SL, Sekaly RP, Sad S. Intrinsic Role of FoxO3a in the Development of CD8+ T Cell Memory. J Immunol. 2013 Feb 1;190(3):1066-75. doi: 10.4049/jimmunol.1200639. Epub 2012 Dec 31. PMID: 23277488

  31. Wilson CL, Gough PJ, Chang CA, Chan CK, Frey JM, Liu Y, Braun KR, Chin MT, Wight TN, Raines EW. Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults. Mech Dev. 2013 Jan 24. pii: S0925-4773(13)00003-8. doi: 10.1016/j.mod.2013.01.001. [Epub ahead of print] PMID: 23354118

  32. Yang J, James EA, Sanda S, Greenbaum CJ, Kwok WW. CD4+ T cells recognize diverse epitopes within GAD65: implications for repertoire development and diabetes monitoring. Immunology. 2013 Mar;138(3):269-79. doi: 10.1111/imm.12034. PMID: 23228173

  33. Yee NK, Hamerman JA. β(2) integrins inhibit TLR responses by regulating NF-κβ pathway and p38 MAPK activation. Eur J Immunol. 2013 Jan 11. doi: 10.1002/eji.201242550. [Epub ahead of print] PMID: 23310953

  34. Ziegler SF, Roan F, Bell BD, Stoklasek TA, Kitajima M, Han H. The Biology of Thymic Stromal Lymphopoietin (TSLP). Adv Pharmacol. 2013;66:129-55. doi: 10.1016/B978-0-12-404717-4.00004-4. PMID: 23433457

March - June

  1. Amemiya CT, Alföldi J, Lee AP, Fan S, Philippe H, Maccallum I, Braasch I, Manousaki T, Schneider I, Rohner N, Organ C, Chalopin D, Smith JJ, Robinson M, Dorrington RA, Gerdol M, Aken B, Biscotti MA, Barucca M, Baurain D, Berlin AM, Blatch GL, Buonocore F, Burmester T, Campbell MS, Canapa A, Cannon JP, Christoffels A, De Moro G, Edkins AL, Fan L, Fausto AM, Feiner N, Forconi M, Gamieldien J, Gnerre S, Gnirke A, Goldstone JV, Haerty W, Hahn ME, Hesse U, Hoffmann S, Johnson J, Karchner SI, Kuraku S, Lara M, Levin JZ, Litman GW, Mauceli E, Miyake T, Mueller MG, Nelson DR, Nitsche A, Olmo E, Ota T, Pallavicini A, Panji S, Picone B, Ponting CP, Prohaska SJ, Przybylski D, Saha NR, Ravi V, Ribeiro FJ, Sauka-Spengler T, Scapigliati G, Searle SM, Sharpe T, Simakov O, Stadler PF, Stegeman JJ, Sumiyama K, Tabbaa D, Tafer H, Turner-Maier J, van Heusden P, White S, Williams L, Yandell M, Brinkmann H, Volff JN, Tabin CJ, Shubin N, Schartl M, Jaffe DB, Postlethwait JH, Venkatesh B, Di Palma F, Lander ES, Meyer A, Lindblad-Toh K. The African coelacanth genome provides insights into tetrapod evolution. Nature. 2013 Apr 18;496(7445):311-6. doi: 10.1038/nature12027. PMID: 23598338 / PMC3633110

  2. Amemiya CT, Wagner GP. Francis (frank) hugh ruddle (1929-2013). J Exp Zool B Mol Dev Evol. 2013 Jul;320(5):273-5. doi: 10.1002/jez.b.22509. PMID: 23650107

  3. Chiche L, Jourde-Chiche N, Pascual V, Chaussabel D. Current perspectives on systems immunology approaches to rheumatic diseases. Arthritis Rheum. 2013 Jun;65(6):1407-17. doi: 10.1002/art.37909. PMID: 23450649

  4. Duhen R, Glatigny S, Arbelaez CA, Blair TC, Oukka M, Bettelli E. Cutting Edge: the pathogenicity of IFN-γ-producing Th17 cells is independent of T-bet. J Immunol. 2013 May 1;190(9):4478-82. doi: 10.4049/jimmunol.1203172. Epub 2013 Mar 29. PMID: 23543757

  5. Handa P, Kowdley KV. Dendritic cells in NASH: friend or foe? Ann Hepatol. 2013 May-Jun;12(3):508-9. PMID: 23619272

  6. Hoofnagle JH, Van Natta ML, Kleiner DE, Clark JM, Kowdley KV, Loomba R, Neuschwander-Tetri BA, Sanyal AJ, Tonascia J; Non-alcoholic Steatohepatitis Clinical Research Network [Nelson JE]. Vitamin E and changes in serum alanine aminotransferase levels in patients with non-alcoholic steatohepatitis. Aliment Pharmacol Ther. 2013 Jul;38(2):134-43. doi: 10.1111/apt.12352. PMID: 23718573

  7. Huang C, Martin S, Pfleger C, Du J, Buckner JH, Bluestone JA, Riley JL, Ziegler SF. Cutting Edge: a novel, human-specific interacting protein couples FOXP3 to a chromatin-remodeling complex that contains KAP1/TRIM28. J Immunol. 2013 May 1;190(9):4470-3. doi: 10.4049/jimmunol.1203561. Epub 2013 Mar 29. PMID: 23543754

  8. Jacobson IM, Gordon SC, Kowdley KV, Yoshida EM, Rodriguez-Torres M, Sulkowski MS, Shiffman ML, Lawitz E, Everson G, Bennett M, Schiff E, Al-Assi MT, Subramanian GM, An D, Lin M, McNally J, Brainard D, Symonds WT, McHutchison JG, Patel K, Feld J, Pianko S, Nelson DR; POSITRON Study; FUSION Study. Sofosbuvir for hepatitis C genotype 2 or 3 in patients without treatment options. N Engl J Med. 2013 May 16;368(20):1867-77. doi: 10.1056/NEJMoa1214854. PMID: 23607593

  9. Kowdley KV, Lawitz E, Crespo I, Hassanein T, Davis MN, DeMicco M, Bernstein DE, Afdhal N, Vierling JM, Gordon SC, Anderson JK, Hyland RH, Dvory-Sobol H, An D, Hindes RG, Albanis E, Symonds WT, Berrey MM, Nelson DR, Jacobson IM. Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial. Lancet. 2013 Jun 15;381(9883):2100-7. doi: 10.1016/S0140-6736(13)60247-0. PMID: 23499440

  10. Kowdley KV, Nelson J. Reply. Hepatology. 2013 May;57(5):2095. doi: 10.1002/hep.26073. PMID: 22987775

  11. Larson RP, Comeau MR, Ziegler SF. Cutting edge: allergen-specific CD4 T cells respond indirectly to thymic stromal lymphopoietin to promote allergic responses in the skin. J Immunol. 2013 May 1;190(9):4474-7. doi: 10.4049/jimmunol.1201677. Epub 2013 Mar 29. PMID: 23543759 / PMC3657711

  12. Lawitz E, Lalezari JP, Hassanein T, Kowdley KV, Poordad FF, Sheikh AM, Afdhal NH, Bernstein DE, Dejesus E, Freilich B, Nelson DR, Dieterich DT, Jacobson IM, Jensen D, Abrams GA, Darling JM, Rodriguez-Torres M, Reddy KR, Sulkowski MS, Bzowej NH, Hyland RH, Mo H, Lin M, Mader M, Hindes R, Albanis E, Symonds WT, Berrey MM, Muir A. Sofosbuvir in combination with peginterferon alfa-2a and ribavirin for non-cirrhotic, treatment-naive patients with genotypes 1, 2, and 3 hepatitis C infection: a randomised, double-blind, phase 2 trial. Lancet Infect Dis. 2013 May;13(5):401-8. doi: 10.1016/S1473-3099(13)70033-1. PMID: 23499158

  13. Lawitz E, Mangia A, Wyles D, Rodriguez-Torres M, Hassanein T, Gordon SC, Schultz M, Davis MN, Kayali Z, Reddy KR, Jacobson IM, Kowdley KV, Nyberg L, Subramanian GM, Hyland RH, Arterburn S, Jiang D, McNally J, Brainard D, Symonds WT, McHutchison JG, Sheikh AM, Younossi Z, Gane EJ. Sofosbuvir for previously untreated chronic hepatitis C infection. N Engl J Med. 2013 May 16;368(20):1878-87. doi: 10.1056/NEJMoa1214853. PMID: 23607594

  14. Li X, Xu F, Karoopongse E, Marcondes AM, Lee K, Kowdley KV, Miao CH, Trobridge GD, Campbell JS, Deeg HJ. Allogeneic Transplantations, Fas Signaling, and Dysregulation of Hepcidin. Biol Blood Marrow Transplant. 2013 May 22. pii: S1083-8791(13)00225-5. doi: 10.1016/j.bbmt.2013.05.012. PMID: 23707854

  15. Matta J, Baratin M, Chiche L, Forel JM, Cognet C, Thomas G, Farnarier C, Piperoglou C, Papazian L, Chaussabel D, Ugolini S, Vély F, Vivier E. Induction of B7-H6, a ligand for the Natural Killer cell activating receptor NKp30, in inflammatory conditions. Blood. 2013 May 17. [Epub ahead of print] PMID: 23687088

  16. Messner DJ, Rhieu BH, Kowdley KV. Iron Overload Causes Oxidative Stress and Impaired Insulin Signaling in AML-12 Hepatocytes. Dig Dis Sci. 2013 Jul;58(7):1899-908. doi: 10.1007/s10620-013-2648-3. PMID: 23558563 / PMC3700657

  17. Miazgowicz MM, Elliott MS, Debley JS, Ziegler SF. Respiratory syncytial virus induces functional thymic stromal lymphopoietin receptor in airway epithelial cells. J Inflamm Res. 2013;6:53-61. doi: 10.2147/JIR.S42381. Epub 2013 Mar 24. PMID: 23576878 / PMC3617816

  18. Obermoser G, Presnell S, Domico K, Xu H, Wang Y, Anguiano E, Thompson-Snipes L, Ranganathan R, Zeitner B, Bjork A, Anderson D, Speake C, Ruchaud E, Skinner J, Alsina L, Sharma M, Dutartre H, Cepika A, Israelsson E, Nguyen P, Nguyen QA, Harrod AC, Zurawski SM, Pascual V, Ueno H, Nepom GT, Quinn C, Blankenship D, Palucka K, Banchereau J, Chaussabel D. Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines. Immunity. 2013 Apr 18;38(4):831-44. doi: 10.1016/j.immuni.2012.12.008. PMID: 23601689

  19. Peng SL, Rodriguez D. Abatacept in relapsing polychondritis. Ann Rheum Dis. 2013 Aug;72(8):1427-9. doi: 10.1136/annrheumdis-2013-203319. Epub 2013 Apr 20. PMID: 23606702

  20. Rudensky AY, Campbell DJ. In vivo sites and cellular mechanisms of T reg cell-mediated suppression. J Exp Med. 2006 Mar 20;203(3):489-92. Epub 2006 Mar 13. PMID: 16533888

  21. Shaffer HB, Minx P, Warren DE, Shedlock AM, Thomson RC, Valenzuela N, Abramyan J, Amemiya CT, Badenhorst D, Biggar KK, Borchert GM, Botka CW, Bowden RM, Braun EL, Bronikowski AM, Bruneau BG, Buck LT, Capel B, Castoe TA, Czerwinski M, Delehaunty KD, Edwards SV, Fronick CC, Fujita MK, Fulton L, Graves TA, Green RE, Haerty W, Hariharan R, Hernandez O, Hillier LW, Holloway AK, Janes D, Janzen FJ, Kandoth C, Kong L, de Koning AJ, Li Y, Literman R, McGaugh SE, Mork L, O'Laughlin M, Paitz RT, Pollock DD, Ponting CP, Radhakrishnan S, Raney BJ, Richman JM, St John J, Schwartz T, Sethuraman A, Spinks PQ, Storey KB, Thane N, Vinar T, Zimmerman LM, Warren WC, Mardis ER, Wilson RK. The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage. Genome Biol. 2013 Mar 28;14(3):R28. PMID: 23537068

  22. Shah N, Pierce T, Kowdley KV. Review of direct-acting antiviral agents for the treatment of chronic hepatitis C. Expert Opin Investig Drugs. 2013 Jun 4. [Epub ahead of print] PMID: 23735127

  23. Sulkowski MS, Poordad F, Manns MP, Bronowicki JP, Rajender Reddy K, Harrison SA, Afdhal NH, Sings HL, Pedicone LD, Koury KJ, Sniukiene V, Burroughs MH, Albrecht JK, Brass CA, Jacobson IM; SPRINT-2 Trial Investigators [Kowdley KV] Anemia during treatment with peginterferon Alfa-2b/ribavirin and boceprevir: Analysis from the serine protease inhibitor therapy 2 (SPRINT-2) trial. Hepatology. 2013 Mar;57(3):974-84. doi: 10.1002/hep.26096. PMID: 23081753

  24. Tong MJ, Kowdley KV, Pan C, Hu KQ, Chang TT, Han KH, Yoon SK, Goodman ZD, Beebe S, Iloeje U, Tang H. Improvement in liver histology among Asian patients with chronic hepatitis B after long-term treatment with entecavir. Liver Int. 2013 Apr;33(4):650-1. doi: 10.1111/liv.12121. PMID: 23489906

  25. Vuppalanchi R, Troutt JS, Konrad RJ, Ghabril M, Saxena R, Bell LN, Kowdley KV, Chalasani N. Serum hepcidin levels are associated with obesity but not liver disease. Obesity (Silver Spring). 2013 Mar 20. doi: 10.1002/oby.20403. PMID: 23512600 / PMC3692602

July - September

  1. Ahmed ST, Akirav E, Bradshaw E, Buckner J, McKinney E, Quintana FJ, Waldron-Lynch F, Nepom J. Immunological biomarkers: catalysts for translational advances in autoimmune diabetes. Clin Exp Immunol. 2013 May;172(2):178-85. doi: 10.1111/cei.12063. PMID: 23574315

  2. Bloom CI, Graham CM, Berry MP, Rozakeas F, Redford PS, Wang Y, Xu Z, Wilkinson KA, Wilkinson RJ, Kendrick Y, Devouassoux G, Ferry T, Miyara M, Bouvry D, Dominique V, Gorochov G, Blankenship D, Saadatian M, Vanhems P, Beynon H, Vancheeswaran R, Wickremasinghe M, Chaussabel D, Banchereau J, Pascual V, Ho LP, Lipman M, O'Garra A. Transcriptional blood signatures distinguish pulmonary tuberculosis, pulmonary sarcoidosis, pneumonias and lung cancers. PLoS One. 2013 Aug 5;8(8):e70630. doi: 10.1371/journal.pone.0070630. Print 2013. PMID: 23940611

  3. Bollyky JB, Long SA, Fitch M, Bollyky PL, Rieck M, Rogers R, Samuels PL, Sanda S, Buckner JH, Hellerstein MK, Greenbaum CJ. Evaluation of in vivo T cell kinetics: use of heavy isotope labelling in type 1 diabetes. Clin Exp Immunol. 2013 June. PMID: 23600824

  4. Bollyky PL, Vernon RB, Falk BA, Preisinger A, Gooden MD, Nepom GT, Gebe JA. IL-10 induction from implants delivering pancreatic islets and hyaluronan. J Diabetes Res. 2013;2013:342479. doi: 10.1155/2013/342479. Epub 2013 Jul 22. PMID: 23971054

  5. Crume TL, Andrews JS, D'Agostino RB, Pettitt DJ, Mayer-Davis EJ, Law JR, Dolan L, Lawrence JM, Saydah S, Greenbaum C, Rodriguez BL, Dabelea D. The Influence of exposure to maternal diabetes in utero on the rate of decline in beta-cell function among youth with diabetes. J Pediatr Endocrinol Metab, 2013 PMID: 23645121

  6. Gilliam LK, Pihoker C, Ellard S, Hattersley AT, Dabelea D, Davis C, Dolan LM, Greenbaum CJ, Imperatore G, Lawrence JM, Marcovina SM, Mayer-Davis E, Rodriguez BL, Steck AK, Williams DE; for the SEARCH for Diabetes In Youth Study Group. Prevalence, Characteristics and Clinical Diagnosis of Maturity Onset Diabetes in Youth Due to Mutation sin HNF1A, HNF4A, and Glucokinase: Results from the SEARCH for Diabetes in Youth. J Clin Endocrinol Metab, 2013 June 14. PMID: 23771925

  7. Herold KC, Gitelman SE, Ehlers MR, Gottlieb PA, Greenbaum CJ, Hagopian W, Boyle KD, Keys-Elstein L, Aggarwal S, Phippard D, Sayre PH, McNamara J, Bluestone JA,; the AbATE Study Team. Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a ramdomized controlled trial: Metabolic and immunologic features at baseline identify a subgroup of responders. Diabetes, 2013 July 8. PMID: 23835333

  8. Kanwar P, Kowdley KV. Diagnosis and treatment of hereditary hemochromatosis: an update. Expert Rev Gastroenterol Hepatol. 2013 Aug;7(6):517-30. doi: 10.1586/17474124.2013.816114. PMID: 23985001

  9. Kean TJ, Lin P, Caplan AI, Dennis JE. MSCs: Delivery Routes and Engraftment, Cell-Targeting Strategies, and Immune Modulation. Stem Cells Int. 2013;2013:732742. doi: 10.1155/2013/732742. Epub 2013 Aug 13. PMID: 24000286

  10. Kuhn LT, Liu Y, Boyd NL, Dennis J, Jiang X, Xin X, Charles L, Wang L, Aguila HL, Rowe D, Lichtler A, Goldberg AJ. Developmental-like Bone Regeneration By Human Embryonic Stem Cell-derived Mesenchymal Cells. Tissue Eng Part A. 2013 Aug 17. [Epub ahead of print] PMID: 23952622

  11. Lin P, Correa D, Kean TJ, Awadallah A, Dennis JE, Caplan AI. Serial Transplantation and Long-Term Engraftment of Intraarterially Delivered Clonally-Derived Mesenchymal Stem Cells to Injured Bone Marrow. Mol Ther. 2013 Sep 25. doi: 10.1038/mt.2013.221. [Epub ahead of print] PMID: 24067545

  12. Mauseth R, Hirsch IR, Bollyky J, Kircher R, Matheson D, Sanda S, Greenbaum C. Use of a "fuzzy logic" controller in a closed-loop artificial pancreas. Diabetes Technol ther, 2013 Aug 15(8). PMID: 23829285

  13. McNab FW, Ewbank J, Rajsbaum R, Stavropoulos E, Martirosyan A, Redford PS, Wu X, Graham CM, Saraiva M, Tsichlis P, Chaussabel D, Ley SC, O'Garra A. TPL-2-ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I IFN production. J Immunol. 2013 Aug 15;191(4):1732-43. doi: 10.4049/jimmunol.1300146. Epub 2013 Jul 10. PMID: 23842752

  14. Moran A, Bundy B, Becker DJ, DiMeglio LA, Gitelman SE, Goland R, Greenbaum CJ, Herold KC, Marks JB, Raskin P, Sanda S, Schatz D, Wherrett DK, Wilson DM, Krischer JP, Skyler JS; Type 1 Diabetes TrialNet Canakinumab Study Group, Pickersgill L, de Koning E, Ziegler AG, Böehm B, Badenhoop K, Schloot N, Bak JF, Pozzilli P, Mauricio D, Donath MY, Castano L, Wagner A, Lervang HH, Perrid H, Mandrup-Pouslen T; AIDA Study Group, Pociot F, Dinarello CA. Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicenter, randomized, double-blind, placebo-controlled trials. Lancet 2013 Jun 1. PMID: 23562090

  15. Nepom GT, Ehlers M, Mandrup-Poulsen T. Anti-cytokine therapies in T1D: Concepts and strategies. Clin Immunol. 2013 Feb 14. pii: S1521-6616(13)00029-6. doi: 10.1016/j.clim.2013.02.003. [Epub ahead of print] PMID: 23510726

  16. Pescovitz MD, Greenbaum CJ, Bundy B, Beker DJ, Gitelman SE, Goland R, Gottlieb PA, Marks JB, Moran A, Raskin P, Rodriguez H, Schatz DA, Wherrett DK, Wilson DM, Krischer JP, Skyler JS; and the Type 1 Diabetes TrialNet Anti-CD20 Study Group. B-Lymphocyte Depletion with Rituximab and Beta-Cell Function: Two-Year Results. Diabetes Care, 2013, Sep 11. PMID: 24026563

  17. Sosenko JM, Skyler JS, Beam CA, Krischer JP, Greenbaum CJ, Mahon J, Rafkin LE, Matheson D, Herold KC, Palmer JP; The Diabetes Type 1 TrialNet and Diabetes Prevention Trial-Type 1 Study Groups. The Acceleration of the Loss of the First-Phase Insulin Response during the Progression to Type 1 Diabetes in Diabetes Prevention Trial-Type 1 Participants. Diabetes, 2013 July 17. PMID: 23863814

October - December 2013

  1. Bambha K, Wilson LA, Unalp A, Loomba R, Neuschwander-Tetri BA, Brunt EM, Bass NM; NASH CRN [Kowdley KV, Nelson JE]. Coffee consumption in NAFLD patients with lower insulin resistance is associated with lower risk of severe fibrosis. Liver Int. 2013 Nov 5. doi: 10.1111/liv.12379. PMID: 24267865

  2. Buckingham B, Beck RW, Ruedy KJ, Cheng P, Kollman C, Weinzimer SA, DiMeglio LA, Bremer AA, Slover R, Tamborlane WV; Diabetes Research in Children Network (DirecNet) Study Group; Type 1 Diabetes TrialNet Study Group [Buckner JH]. Effectiveness of early intensive therapy on β-cell preservation in type 1 diabetes. Diabetes Care. 2013 Dec;36(12):4030-5. doi: 10.2337/dc13-1074. Epub 2013 Oct 15. PMID: 24130350

  3. Cerosaletti K, Schneider A, Schwedhelm K, Frank I, Tatum M, Wei S, Whalen E, Greenbaum C, Kita M, Buckner J, Long SA. Multiple Autoimmune-Associated Variants Confer Decreased IL-2R Signaling in DC4(+)CD25(hi) T Cells of Type 1 Diabetic and Multiple Sclerosis Patients. PLoS One. 2013 Dec 23;8(12):e83811. doi: 10.1371/journal.pone.0083811. eCollection 2013. PMID: 24376757 |  PMC3871703

  4. Dahan R, Gebe JA, Preisinger A, James EA, Tendler M, Nepom GT, Reiter Y. Antigen-specific immunomodulation for type 1 diabetes by novel recombinant antibodies directed against diabetes-associates auto-reactive T cell epitope. J Autoimmun. 2013 Dec;47:83-93. doi: 10.1016/j.jaut.2013.08.009. Epub 2013 Oct 3. PMID: 24090977

  5. Dennis JE, Lord JD. (2013) Mesenchymal stem cells for the treatment of inflammatory bowel disease, In: Gross, Gerhard / Häupl, Thomas (Eds.) Stem Cell-Dependent Therapies: Mesenchymal Stem Cells in Chronic Inflammatory Disorders (pp. 211-224). DeGruyter; Berlin, Germany.

  6. Estorninho M, Gibson VB, Kronenberg-Versteeg D, Liu YF, Ni C, Cerosaletti K, Peakman M. A novel approach to tracking antigen-experienced CD4 T cells into functional compartments via tandem deep and shallow TCR clonotyping. J Immunol. 2013 Dec 1;191(11):5430-40. doi: 10.4049/jimmunol.1300622. Epub 2013 Oct 25. PMID: 24163407

  7. Handa P, Maliken BD, Nelson JE, Morgan-Stevenson V, Messner DJ, Dhillon BK, Klintworth HM, Beauchamp M, Yeh MM, Elfers CT, Roth CL, Kowdley KV. Reduced adiponectin signaling due to weight gain results in nonalcoholic steatohepatitis through impaired mitochondrial biogenesis. Hepatology. 2013 Nov 21. doi: 10.1002/hep.26946. PMID: 24464605

  8. Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH, Sheppard D. Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med. 2013 Dec;19(12):1617-24. doi: 10.1038/nm.3282. Epub 2013 Nov 10. PMID: 24216753

  9. James EA, LaFond RE, Gates TJ, Mai DT, Malhotra U, Kwok WW. Yellow fever vaccination elicits broad functional CD4+ T cell responses that recognize structural and nonstructural proteins. J Virol. 2013 Dec;87(23):12794-804. doi: 10.1128/JVI.01160-13. Epub 2013 Sep 18. PMID: 24049183

  10. Kailaanmäki A, Kinnunen T, Kwok WW, Rytkönen-Nissinen M, Randell J, Virtanen T. Differential CD4(+) T-cell responses of allergic and non-allergic subjects to the immunodominant epitope region of the horse major allergen Equ c 1. Immunology. 2014 Jan;141(1):52-60. doi: 10.1111/imm.12166. PMID: 23991693

  11. Kanwar P, Kowdley KV. Metal storage disorders: Wilson disease and hemochromatosis. Med Clin North Am. 2014 Jan;98(1):87-102. doi: 10.1016/j.mcna.2013.09.008. Epub 2013 Oct 28. PMID: 24266916

  12. Kowdley KV, Burman BE. ACP Journal Club. Adding rifaximin to lactulose increased reversal and decreased mortality in hepatic encephalopathy. Ann Intern Med. 2013 Oct 15;159(8):JC8. doi: 10.7326/0003-4819-159-8-201310150-02008. PMID: 24126669

  13. Mejias A, Dimo B, Suarez NM, Garcia C, Suarez-Arrabal MC, Jartti T, Blankenship D, Jordan-Villegas A, Ardura MI, Xu Z, Banchereau J, Chaussabel D, Ramilo O. Whole blood gene expression profiles to assess pathogenesis and disease severity in infants with respiratory syncytial virus infection. PLoS Med. 2013 Nov;10(11):e1001549. doi: 10.1371/journal.pmed.1001549. Epub 2013 Nov 12. PMID: 24265599

  14. Nitsche A, Doose G, Tafer H, Robinson M, Saha NR, Gerdol M, Canapa A, Hoffmann S, Amemiya CT, Stadler PF. Atypical RNAs in the coelacanth transcriptome. J Exp Zool B Mol Dev Evol. 2013 Oct 30. doi: 10.1002/jez.b.22542. [Epub ahead of print] PMID: 24174405

  15. Noureddin M, Yates KP, Vaughn IA, Neuschwander-Tetri BA, Sanyal AJ, McCullough A, Merriman R, Hameed B, Doo E, Kleiner DE, Behling C, Loomba R; NASH CRN [Kowdley KV, Nelson JE]. Clinical and histological determinants of nonalcoholic steatohepatitis and advanced fibrosis in elderly patients. Hepatology. 2013 Nov;58(5):1644-54. doi: 10.1002/hep.26465. PMID: 23686698 | PMC3760979

  16. Obika M, Vernon RB, Gooden MD, Braun KR, Chan CK, Wight TN. ADAMTS-4 and Biglycan are Expressed at High Levels and Co-Localize to Podosomes During Endothelial Cell Tubulogenesis In Vitro. J Histochem Cytochem. 2014 Jan;62(1):34-49. doi: 10.1369/0022155413507727. Epub 2013 Sep 18. PMID: 24051360

  17. Orban T, Bundy B, Becker DJ, Dimeglio LA, Gitelman SE, Goland R, Gottlieb PA, Greenbaum CJ, Marks JP, Monzavi R, Moran A, Peakman M, Raskin P, Russell WE, Schatz D, Wherrett DK, Wilson MD, Krischer JP, Skyler JS; the Type 1 Diabetes TrialNet Abatacept Study Group.  Co-Stimulation Modulation with Abatacept in Patients with Recent-Onset Type 1 Diabetes: Follow-up One Year After Cessation of Treatment. Diabetes Care, 2013 Dec 2 PMID: 24296850

  18. Park J, Munagala I, Xu H, Blankenship D, Maffucci P, Chaussabel D, Banchereau J, Pascual V, Cunningham-Rundles C. Interferon signature in the blood in inflammatory common variable immune deficiency. PLoS One. 2013 Sep 17;8(9):e74893. doi: 10.1371/journal.pone.0074893. PMID: 24069364

  19. Pieper J, Johansson S, Snir O, Linton L, Rieck M, Buckner JH, Winqvist O, van Vollenhoven R, Malmström V. Peripheral and site-specific CD4(+) CD28(null) T cells from rheumatoid arthritis patients show distinct characteristics. Scand J Immunol. 2014 Feb;79(2):149-55. doi: 10.1111/sji.12139. PMID: 24313359

  20. Rigby MR, Dimeglio LA, Rendell MS, Felner EI, Dostou JM, Gitelman SE, Patel CM, Griffin KJ, Tsalikian E, Gottlieb PA, Greenbaum CJ, Sherry NA, Moore WV, Monzavi R, Willi SM, Raskin P, Moran A, Russell WE, Pinckney A, Keyes-Elstein L, Howell M, Aggarwal S, Lim N, Phippard D, Nepom GT, McNamara J, Ehlers MR; T1DAL Study Team. Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL Study): 12 month results of a randomized, double-blind, placebo-controlled phase 2 trial. Lancet Diabetes Endocrinol. 2013 Dec;1(4):284-94. doi: 10.1016/S2213-8587(13)70111-6. Epub 2013 Sep 23. PMID: 24622414

  21. Shah N, Nelson JE, Kowdley KV. MicroRNAs in Liver Disease: Bench to Bedside. J Clin Exp Hepatol. 2013 Sep;3(3):231-42.  dx.doi.org/10.1016/j.jceh.2013.09.001.

  22. Siddique A, Nelson JE, Aouizerat B, Yeh MM, Kowdley KV; NASH Clinical Research Network. Iron Deficiency in Patients with Nonalcoholic Fatty Liver Disease Is Associated with Obesity, Female Gender, and Low Serum Hepcidin. Clin Gastroenterol Hepatol. 2013 Nov 20. pii: S1542-3565(13)01784-9. doi: 10.1016/j.cgh.2013.11.017. [Epub ahead of print] PMID: 24269922

  23. Till SJ, Raynsford EJ, Reynolds CJ, Quigley KJ, Grzybowska-Kowalczyk A, Saggar LR, Goldstone A, Maillere B, Kwok WW, Altmann DM, Durham SR, Boyton RJ. Peptide-induced immune regulation by a promiscuous and immunodominant CD4T-cell epitope of Timothy grass pollen: a role of Cbl-b and Itch in regulation. Thorax. 2013 Nov 20. doi: 10.1136/thoraxjnl-2013-204324. (not previously reported) PMID: 24258832

  24. Utzschneider KM, Largajolli A, Bertoldo A, Marcovina S, Nelson JE, Yeh MM, Kowdley KV, Kahn SE. Serum ferritin is associated with non-alcoholic fatty liver disease and decreased Β-cell function in non-diabetic men and women. J Diabetes Complications. 2013 Nov 26. pii: S1056-8727(13)00285-7. doi: 10.1016/j.jdiacomp.2013.11.007. [Epub ahead of print] PMID: 24360972

  25. Wambre E, DeLong JH, James EA, Torres-Chinn N, Pfützner W, Möbs C, Durham SR, Till SJ, Robinson D, Kwok WW. Specific immunotherapy modifies allergen-specific CD4(+) T-cell responses in an epitope-dependent manner. J Allergy Clin Immunol. 2014 Mar;133(3):872-879.e7. doi: 10.1016/j.jaci.2013.10.054. Epub 2013 Dec 25. PMID: 24373351 | PMC3961577

  26. Wen J, Cerosaletti K, Schultz KJ, Wright JA, Concannon P. NBN phosphorylation regulates the accumulation of MRN and ATM at sites of DNA double-strand breaks. Oncogene. 2013 Sep 12;32(37):4448-56. doi: 10.1038/onc.2012.443. Epub 2012 Nov 12. PMID: 23146902

  27. Zaidi MB, Estrada-García T, Campos FD, Chim R, Arjona F, Leon M, Michell A, Chaussabel D. Incidence, clinical presentation, and antimicrobial resistance trends in Salmonella and Shigella infections from children in Yucatan, Mexico. Front Microbiol. 2013 Oct 1;4:288. doi: 10.3389/fmicb.2013.00288. PMID: 24098297