Publications

The following list highlights BRI's 2020 publications. More selective listings of publications are also included on scientist biography pages. BRI Principal Investigators are listed in bold.

  1. Abdelsamed HA, Zebley CC, Nguyen H, Rutishauser RL, Fan Y, Ghoneim HE, Crawford JC, Alfei F, Alli S, Ribeiro SP, Castellaw AH, McGargill MA, Jin H, Boi SK, Speake C, Serti E, Turka LA, Busch ME, Stone M, Deeks SG, Sekaly RP, Zehn D, James EA, Nepom GT, Youngblood B. Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes. Nat Immunol. 2020 Mar 30. doi: 10.1038/s41590-020-0633-5. PMID: 32231298

  2. Barretto KT, Brockman-Schneider RA, Kuipers I, Basnet S, Bochkov YA, Altman MC, Jarjour NN, Gern JE, Esnault S. Human Airway Epithelial Cells Express a Functional IL-5 Receptor. Allergy. 2020 Apr 4. doi: 10.1111/all.14297. No abstract available. PMID: 32246831

  3. Berkson JD, Slichter CK, DeBerg HA, Delaney MA, Woodward-Davis AS, Maurice NJ, Lwo Y, Ko A, Hsu J, Chiu YW, Linsley PS, Dixon D, Prlic M. Inflammatory Cytokines Induce Sustained CTLA-4 Cell Surface Expression on Human MAIT Cells. Immunohorizons. 2020 Jan 23;4(1):14-22. doi: 10.4049/immunohorizons.1900061. PMID: 31974109

  4. Bogdani M, Speake C, Dufort MJ, Johnson PY, Larmore MJ, Day AJ, Wight TN, Lernmark Å, Greenbaum CJ. Hyaluronan deposition in islets may precede and direct the location of islet immune-cell infiltrates. Diabetologia. 2020 Jan 6. doi: 10.1007/s00125-019-05066-7. PMID: 31907557 | PMC7002022

  5. Bolouri H, Young M, Beilke J, Johnson R, Fox B, Huang L, Santini CC, Hill CM, Vries AVV, Shannon PT, Dervan A, Sivakumar P, Trotter M, Bassett D, Ratushny A. Integrative network modeling reveals mechanisms underlying T cell exhaustion. Sci Rep. 2020 Feb 5;10(1):1915. doi: 10.1038/s41598-020-58600-8. PMID: 32024856 | PMC7002445

  6. Brough HA, Nadeau KC, Sindher SB, Alkotob SS, Chan S, Bahnson H, Leung DYM, Lack G. Epicutaneous sensitization in the development of food allergy: what is the evidence and how can this be prevented? Allergy. 2020 Apr 6. doi: 10.1111/all.14304. Review. PMID: 32249942

  7. Gratz IK, Campbell DJ. Resident memory T cells show that it is never too late to change your ways. Nat Immunol. 2020 Apr;21(4):359-360. doi: 10.1038/s41590-020-0637-1. PMID: 32205885

  8. Harten IA, Kaber G, Agarwal KJ, Kang I, Ibarrientos SR, Workman G, Chan CK, Nivison MP, Nagy N, Braun KR, Kinsella MG, Merrilees MJ, Wight TN. The Synthesis and Secretion of Versican Isoform V3 by Mammalian Cells: A Role for N-linked Glycosylation. Matrix Biol. 2020 Jan 27. pii: S0945-053X(20)30008-1. doi: 10.1016/j.matbio.2020.01.002. PMID: 32001344

  9. Kabata H, Flamar AL, Mahlakõiv T, Moriyama S, Rodewald HR, Ziegler SF, Artis D. Targeted deletion of the TSLP receptor reveals cellular mechanisms that promote type 2 airway inflammation. Mucosal Immunol. 2020 Feb 17. doi: 10.1038/s41385-020-0266-x. PMID: 32066836

  10. Lande R, Palazzo R, Gestermann N, Jandus C, Falchi M, Spadaro F, Riccieri V, James EA, Butera A, Boirivant M, Feldmeyer L, Surbeck I, Di Lucca J, Stuber F, Spinelli FR, Botti E, Marinari B, Bianchi L, Pica R, Cerbelli B, Giannakakis K, Auteri SE, Daniels I, Durrant LG, Horstman S, Costanzo A, Romero P, Alessandri C, Conti F, Valesini G, Gilliet M, Chizzolini C, Frasca L. Native/citrullinated LL37-specific T-cells help autoantibody production in Systemic Lupus Erythematosus. Sci Rep. 2020 Apr 3;10(1):5851. doi: 10.1038/s41598-020-62480-3. PMID: 32245990 | PMC7125190

  11. Larson D, Patel P, Salapatek AM, Couroux P, Whitehouse D, Pina A, Johnson JL, Sever ML, Sanda S, Poyser J, Allio T, Scadding GW, Qin T, Shamji MH, Kwok WW, James EA, French D, Lelic A, Larché M, Altman MC, Togias A, Durham SR. Nasal Allergen Challenge and Environmental Exposure Chamber Challenge: A Randomized Trial Comparing Clinical and Biological Responses to Cat Allergen. J Allergy Clin Immunol. 2020 Mar 10. pii: S0091-6749(20)30332-8. doi: 10.1016/j.jaci.2020.02.024. PMID: 32169380

  12. Leyva-Castillo JM, Galand C, Mashiko S, Bissonnette R, McGurk A, Ziegler SF, Dong C, McKenzie ANJ, Sarfati M, Geha RS. ILC2 activation by keratinocyte-derived IL-25 drives IL-13 production at sites of allergic skin inflammation. J Allergy Clin Immunol. 2020 Mar 13. pii: S0091-6749(20)30334-1. doi: 10.1016/j.jaci.2020.02.026. PMID: 32179159

  13. Li D, Matta B, Song S, Nelson V, Diggins K, Simpfendorfer KR, Gregersen PK, Linsley P, Barnes BJ. IRF5 genetic risk variants drive myeloid-specific IRF5 hyperactivation and presymptomatic SLE. JCI Insight. 2020 Jan 30;5(2). pii: 124020. doi: 10.1172/jci.insight.124020. PMID: 31877114

  14. Perkin MR, Bahnson HT, Lack G; EAT Study Team. Reply. J Allergy Clin Immunol. 2020 Feb 25. pii: S0091-6749(20)30103-2. doi: 10.1016/j.jaci.2020.01.015. PMID: 32111420

  15. Reeves SR, Barrow KA, Rich LM, White MP, Shubin NJ, Chan CK, Kang I, Ziegler SF, Piliponsky AM, Wight TN, Debley JS. Respiratory Syncytial Virus Infection of Human Lung Fibroblasts Induces a Hyaluronan-Enriched Extracellular Matrix That Binds Mast Cells and Enhances Expression of Mast Cell Proteases. Front Immunol. 2020 Jan 28;10:3159. doi: 10.3389/fimmu.2019.03159. PMID: 32047499 | PMC6997473

  16. Santos AF, Barbosa-Morais NL, Hurlburt BK, Ramaswamy S, Hemmings O, Kwok M, O'Rourke C, Bahnson HT, Cheng H, James L, Gould HJ, Sutton BJ, Maleki SJ, Lack G. IgE to epitopes of Ara h 2 enhance the diagnostic accuracy of Ara h 2-specific IgE. Allergy. 2020 Apr 4. doi: 10.1111/all.14301. PMID: 32248566

  17. Sheih A, Voillet V, Hanafi LA, DeBerg HA, Yajima M, Hawkins R, Gersuk V, Riddell SR, Maloney DG, Wohlfahrt ME, Pande D, Enstrom MR, Kiem HP, Adair JE, Gottardo R, Linsley PS, Turtle CJ. Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy. Nat Commun. 2020 Jan 10;11(1):219. doi: 10.1038/s41467-019-13880-1. PMID: 31924795 | PMC6954177

  18. Shubin NJ, Clauson M, Niino K, Kasprzak V, Tsuha A, Guga E, Bhise G, Acharya M, Snyder JM, Debley JS, Ziegler SF, Piliponsky AM. Thymic stromal lymphopoietin protects in a model of airway damage and inflammation via regulation of caspase-1 activity and apoptosis inhibition. Mucosal Immunol. 2020 Feb 26. doi: 10.1038/s41385-020-0271-0. PMID: 32103153

  19. Sindher S, Alkotob SS, Shojinaga MN, Brough HA, Bahnson T, S C, Lack G, Leung DYM, Nadeau KC. Pilot study measuring transepidermal water loss (TEWL) in children suggests trilipid cream is more effective than a paraffin-based emollient. Allergy. 2020 Mar 16. doi: 10.1111/all.14275. PMID: 32176320

  20. So M, O'Rourke C, Bahnson HT, Greenbaum CJ, Speake C. Autoantibody Reversion: Changing Risk Categories in Multiple-Autoantibody-Positive Individuals. Diabetes Care. 2020 Feb 4. pii: dc191731. doi: 10.2337/dc19-1731. PMID: 32019856

  21. Speake C, Ylescupidez A, Neiman D, Shemer R, Glaser B, Tersey SA, Usmani-Brown S, Clark P, Wilhelm JJ, Bellin MD, Herold KC, Mirmira RG, Dor Y, Evans-Molina C. Circulating unmethylated insulin DNA as a biomarker of human beta cell death: a multi-laboratory assay comparison. J Clin Endocrinol Metab. 2020 Jan 8. pii: dgaa008. doi: 10.1210/clinem/dgaa008. PMID: 31913467 | PMC7015459

  22. Wen X, Yang J, James E, Chow IT, Reijonen H, Kwok WW. Increased islet antigen-specific regulatory and effector CD4+ T cells in healthy individuals with the type 1 diabetes-protective haplotype. Sci Immunol. 2020 Feb 14;5(44). pii: eaax8767. doi: 10.1126/sciimmunol.aax8767. PMID: 32060144

  23. Wiedeman AE, Muir VS, Rosasco MG, DeBerg HA, Presnell S, Haas B, Dufort MJ, Speake C, Greenbaum CJ, Serti E, Nepom GT, Blahnik G, Kus AM, James EA, Linsley PS, Long SA. Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression. J Clin Invest. 2020 Jan 2;130(1):480-490. doi: 10.1172/JCI126595. PMID: 31815738 | PMC6934185

  24. Zhang A, Lacy-Hulbert A, Anderton S, Haslett C, Savill J. Apoptotic cell-directed resolution of lung inflammation requires myeloid αv integrin-mediated induction of regulatory T lymphocytes. Am J Pathol. 2020 Mar 19. pii: S0002-9440(20)30131-0. doi: 10.1016/j.ajpath.2020.02.010. PMID: 32201264

  25. Zhao LP, Papadopoulos GK, Kwok WW, Moustakas AK, Bondinas GP, Larsson HE, Ludvigsson J, Marcus C, Samuelsson U, Wang R, Pyo CW, Nelson WC, Geraghty DE, Lernmark Å. Motifs of Three HLA-DQ Amino Acid Residues (α44, β57, β135) Capture Full Association with the Risk of Type 1 Diabetes in DQ2 and DQ8 Children. Diabetes. 2020 Apr 3. pii: db200075. doi: 10.2337/db20-0075. PMID: 32245799