Publications

The following list highlights BRI's 2019 publications. More selective listings of publications are also included on scientist biography pages. BRI Principal Investigators are listed in bold.

  1. Acevedo-Calado MJ, Pietropaolo SL, Morran MP, Schnell S, Vonberg AD, Verge CF, Gianani R, Becker DJ, Huang S, Greenbaum CJ, Yu L, Davidson HW, Michels AW, Rich SS, Pietropaolo M; Type 1 Diabetes TrialNet Study Group. Autoantibodies Directed to a Novel IA-2 Variant Protein Enhance Prediction of Type 1 Diabetes. Diabetes. 2019 Jun 5. pii: db181351. doi: 10.2337/db18-1351. PMID: 31167877

  2. Ahmed S, Cerosaletti K, James E, Long SA, Mannering S, Speake C, Nakayama M, Tree T, Roep BO, Herold KC, Brusko TM. Standardizing T-Cell Biomarkers in Type 1 Diabetes: Challenges and Recent Advances. Diabetes. 2019 Jul;68(7):1366-1379. doi: 10.2337/db19-0119. PMID: 31221801 | PMC6609980

  3. Akilesh HM, Buechler MB, Duggan JM, Hahn WO, Matta B, Sun X, Gessay G, Whalen E, Mason M, Presnell SR, Elkon KB, Lacy-Hulbert A, Barnes BJ, Pepper M, Hamerman JA. Chronic TLR7 and TLR9 signaling drives anemia via differentiation of specialized hemophagocytes. Science. 2019 Jan 11;363(6423). pii: eaao5213. doi: 10.1126/science.aao5213. PMID: 30630901 | PMC6413693

  4. Altman MC, Gern JE. Reply. J Allergy Clin Immunol. 2019 Jun;143(6):2334-2335. doi: 10.1016/j.jaci.2019.03.006. PMID: 30979657

  5. Altman MC, Gill MA, Whalen E, Babineau DC, Shao B, Liu AH, Jepson B, Gruchalla RS, O'Connor GT, Pongracic JA, Kercsmar CM, Khurana Hershey GK, Zoratti EM, Johnson CC, Teach SJ, Kattan M, Bacharier LB, Beigelman A, Sigelman SM, Presnell S, Gern JE, Gergen PJ, Wheatley LM, Togias A, Busse WW, Jackson DJ. Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children. Nat Immunol. 2019 May;20(5):637-651. doi: 10.1038/s41590-019-0347-8. PMID: 30962590 | PMC6472965

  6. Ayyappan P, Harms RZ, Buckner JH, Sarvetnick NE. Coordinated Induction of Antimicrobial Response Factors in Systemic Lupus Erythematosus. Front Immunol. 2019 Apr 4;10:658. doi: 10.3389/fimmu.2019.00658. eCollection 2019. PMID: 31019506 | PMC6458289

  7. Berens HM, Polinski KJ, Mikuls TR, Khatter S, August J, Visser A, Mahler M, Weisman M, O'Dell JR, Keating RM, Buckner JH, Gregersen PK, Norris JM, Holers VM, Deane KD, Demoruelle MK. Anti-CCP3.1 and Anti-CCP-IgA Are Associated with Increasing Age in Individuals Without Rheumatoid Arthritis. J Rheumatol. 2019 Apr 15. pii: jrheum.180897. doi: 10.3899/jrheum.180897. PMID: 30988128

  8. Carpentier SJ, Ni M, Duggan JM, James RG, Cookson BT, Hamerman JA. The signaling adaptor BCAP inhibits NLRP3 and NLRC4 inflammasome activation in macrophages through interactions with Flightless-1. Sci Signal. 2019 May 14;12(581). pii: eaau0615. doi: 10.1126/scisignal.aau0615. PMID: 31088976 | PMC6604799

  9. Cerosaletti K, Hao W, Greenbaum CJ. Genetics Coming of Age in Type 1 Diabetes. Diabetes Care. 2019 Feb;42(2):189-191. doi: 10.2337/dci18-0039. No abstract available. PMID: 30665964

  10. Chu T, Ni M, Chen C, Akilesh S, Hamerman JA. Cutting Edge: BCAP Promotes Lupus-like Disease and TLR-Mediated Type I IFN Induction in Plasmacytoid Dendritic Cells. J Immunol. 2019 May 1;202(9):2529-2534. doi: 10.4049/jimmunol.1801267. Epub 2019 Apr 1. PMID: 30936294 | PMC6516743

  11. Dam EM, Maier AC, Hocking AM, Carlin J, Ng B, Buckner JH. Corrigendum: Increased Binding of Specificity Protein 1 to the IL21R Promoter in B Cells Results in Enhanced B Cell Responses in Rheumatoid Arthritis. Front Immunol. 2019 May 16;10:1122. doi: 10.3389/fimmu.2019.01122. eCollection 2019. PMID: 31156654 | PMC6532707

  12. Davidson WF, Leung DYM, Beck LA, Berin CM, Boguniewicz M, Busse WW, Chatila TA, Geha RS, Gern JE, Guttman-Yassky E, Irvine AD, Kim BS, Kong HH, Lack G, Nadeau KC, Schwaninger J, Simpson A, Simpson EL, Spergel JM, Togias A, Wahn U, Wood RA, Woodfolk JA, Ziegler SF, Plaut M. Report from the National Institute of Allergy and Infectious Diseases Workshop on "Atopic Dermatitis and the Atopic March: Mechanisms and Interventions". J Allergy Clin Immunol. 2019 Jan 9. pii: S0091-6749(19)30014-4. doi: 10.1016/j.jaci.2019.01.003. PMID: 30639346

  13. Dufort MJ, Greenbaum CJ, Speake C, Linsley PS. Cell type-specific immune phenotypes predict loss of insulin secretion in new-onset type 1 diabetes. JCI Insight. 2019 Feb 21;4(4). pii: 125556. doi: 10.1172/jci.insight.125556. eCollection 2019 Feb 21. PMID: 30830868 | PMC6478408

  14. Eldredge LC, Creasy RS, Presnell S, Debley JS, Juul SE, Mayock DE, Ziegler SF. Infants with evolving bronchopulmonary dysplasia demonstrate monocyte-specific expression of IL-1 in tracheal aspirates. Am J Physiol Lung Cell Mol Physiol. 2019 Jul 1;317(1):L49-L56. doi: 10.1152/ajplung.00060.2019. PMID: 30969811

  15. Eldredge LC, Creasy RS, Tanaka S, Lai JF, Ziegler SF. Imbalance of Ly-6Chi and Ly-6Clo Monocytes/Macrophages Worsens Hyperoxia-Induced Lung Injury and Is Rescued by IFN-γ. J Immunol. 2019 May 1;202(9):2772-2781. doi: 10.4049/jimmunol.1801374. PMID: 30944158

  16. Glatigny S, Höllbacher B, Motley SJ, Tan C, Hundhausen C, Buckner JH, Smilek D, Khoury SJ, Ding L, Qin T, Pardo J, Nepom GT, Turka LA, Harris KM, Campbell DJ, Bettelli E. Abatacept Targets T Follicular Helper and Regulatory T Cells, Disrupting Molecular Pathways That Regulate Their Proliferation and Maintenance. J Immunol. 2019 Jan 25. pii: ji1801425. doi: 10.4049/jimmunol.1801425. PMID: 30683697 | PMC6481683

  17. Gorman JA, Hundhausen C, Kinsman M, Arkatkar T, Allenspach EJ, Clough C, West SE, Thomas K, Eken A, Khim S, Hale M, Oukka M, Jackson SW, Cerosaletti K, Buckner JH, Rawlings DJ. The TYK2-P1104A Autoimmune Protective Variant Limits Coordinate Signals Required to Generate Specialized T Cell Subsets. Front Immunol. 2019 Jan 25;10:44. doi: 10.3389/fimmu.2019.00044. eCollection 2019. PMID: 30740104 | PMC6355696

  18. Greenbaum CJ, VanBuecken D, Lord S. Disease-Modifying Therapies in Type 1 Diabetes: A Look into the Future of Diabetes Practice. Drugs. 2019 Jan;79(1):43-61. doi: 10.1007/s40265-018-1035-y. Review. PMID: 30612319 | PMC6613813

  19. Habib T, Long SA, Samuels PL, Brahmandam A, Tatum M, Funk A, Hocking AM, Cerosaletti K, Mason MT, Whalen E, Rawlings DJ, Greenbaum C, Buckner JH; Type 1 Diabetes TrialNet Study Group. Dynamic Immune Phenotypes of B and T Helper Cells Mark Distinct Stages of T1D Progression. Diabetes. 2019 Mar 20. pii: db181081. doi: 10.2337/db18-1081. PMID: 30894366 | PMC6610015

  20. Haller MJ, Long SA, Blanchfield JL, Schatz DA, Skyler JS, Krischer JP, Bundy BN, Geyer SM, Warnock MV, Miller JL, Atkinson MA, Becker DJ, Baidal DA, DiMeglio LA, Gitelman SE, Goland R, Gottlieb PA, Herold KC, Marks JB, Moran A, Rodriguez H, Russell WE, Wilson DM, Greenbaum CJ, Type 1 Diabetes TrialNet ATG-GCSF Study Group. Low-dose Anti-Thymocyte Globulin Preserves C-Peptide and Reduces A1c in New Onset Type 1 Diabetes: Two Year Clinical Trial Data. Diabetes. 2019 Jun;68(6):1267-1276. doi: 10.2337/db19-0057. PMID: 30967424 | PMC6610026

  21. Herold KC, Bundy BN, Long SA, Bluestone JA, DiMeglio LA, Dufort MJ, Gitelman SE, Gottlieb PA, Krischer JP, Linsley PS, Marks JB, Moore W, Moran A, Rodriguez H, Russell WE, Schatz D, Skyler JS, Tsalikian E, Wherrett DK, Ziegler AG, Greenbaum CJ; Type 1 Diabetes TrialNet Study Group. An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes. N Engl J Med. 2019 Jun 9. doi: 10.1056/NEJMoa1902226. PMID: 31180194

  22. Hope CM, Welch J, Mohandas A, Pederson S, Hill D, Gundsambuu B, Eastaff-Leung N, Grosse R, Bresatz S, Ang G, Papademetrios M, Zola H, Duhen T, Campbell DJ, Brown CY, Krumbiegel D, Sadlon T, Couper JJ, Barry SC. Peptidase inhibitor 16 identifies a human regulatory T-cell subset with reduced FOXP3 expression over the first year of recent onset type 1 diabetes. Eur J Immunol. 2019 May 25. doi: 10.1002/eji.201948094. PMID: 31127857

  23. Hung SC, Hou T, Jiang W, Wang N, Qiao SW, Chow IT, Liu X, van der Burg SH, Koelle DM, Kwok WW, Sollid LM, Mellins ED. Epitope Selection for HLA-DQ2 Presentation: Implications for Celiac Disease and Viral Defense. J Immunol. 2019 Mar 29. pii: ji1801454. doi: 10.4049/jimmunol.1801454. PMID: 30926644 | PMC6494460

  24. James JA, Chen H, Young KA, Bemis EA, Seifert J, Bourn RL, Deane KD, Demoruelle MK, Feser M, O'Dell JR, Weisman MH, Keating RM, Gaffney PM, Kelly JA, Langefeld CD, Harley JB, Robinson W, Hafler DA, O'Connor KC, Buckner JH, Guthridge JM, Norris JM, Holers VM. Latent autoimmunity across disease-specific boundaries in at-risk first-degree relatives of SLE and RA patients. EBioMedicine. 2019 Apr;42:76-85. doi: 10.1016/j.ebiom.2019.03.063. PMID: 30952617 | PMC6491794

  25. Johnson MB, Cerosaletti K, Flanagan SE, Buckner JH. Genetic Mechanisms Highlight Shared Pathways for the Pathogenesis of Polygenic Type 1 Diabetes and Monogenic Autoimmune Diabetes. Curr Diab Rep. 2019 Mar 19;19(5):20. doi: 10.1007/s11892-019-1141-6. Review. PMID: 30888520 | PMC6424922

  26. Kong YY, Kwok WW. Identification of Human Antigen-Specific CD4+ T-Cells with Peptide-MHC Multimer Technologies. Methods Mol Biol. 2019 (May);1988:375-386. doi: 10.1007/978-1-4939-9450-2_26. PMID: 31147953

  27. Leyva-Castillo JM, Galand C, Kam C, Burton O, Gurish M, Musser MA, Goldsmith JD, Hait E, Nurko S, Brombacher F, Dong C, Finkelman FD, Lee RT, Ziegler SF, Chiu I, Austen KF, Geha RS. Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion. Immunity. 2019 Apr 10. pii: S1074-7613(19)30140-2. doi: 10.1016/j.immuni.2019.03.023. PMID: 31027995 | PMC6531322

  28. Linsley PS, Greenbaum CJ, Speake C, Long SA, Dufort MJ. B lymphocyte alterations accompany abatacept resistance in new-onset type 1 diabetes. JCI Insight. 2019 Feb 21;4(4). pii: 126136. doi: 10.1172/jci.insight.126136. eCollection 2019 Feb 21. PMID: 30830871 | PMC6478438

  29. Linsley PS, Long SA. Enforcing the checkpoints: harnessing T-cell exhaustion for therapy of T1D. Curr Opin Endocrinol Diabetes Obes. 2019 Aug;26(4):213-218. doi: 10.1097/MED.0000000000000488. PMID: 31157632

  30. Malinczak CA, Fonseca W, Rasky AJ, Ptaschinski C, Morris S, Ziegler SF, Lukacs NW. Sex-associated TSLP-induced immune alterations following early-life RSV infection leads to enhanced allergic disease. Mucosal Immunol. 2019 May 11. doi: 10.1038/s41385-019-0171-3. PMID: 31076663 | PMC6599479

  31. Perdigoto AL, Preston-Hurlburt P, Clark P, Long SA, Linsley PS, Harris KM, Gitelman SE, Greenbaum CJ, Gottlieb PA, Hagopian W, Woodwyk A, Dziura J, Herold KC; Immune Tolerance Network. Treatment of type 1 diabetes with teplizumab: clinical and immunological follow-up after 7 years from diagnosis. Diabetologia. 2019 Apr;62(4):655-664. doi: 10.1007/s00125-018-4786-9. Epub 2018 Dec 19. PMID: 30569273 | PMC6402971

  32. Pesenacker AM, Chen V, Gillies J, Speake C, Marwaha AK, Sun A, Chow S, Tan R, Elliott T, Dutz JP, Tebbutt SJ, Levings MK. Treg gene signatures predict and measure type 1 diabetes trajectory. JCI Insight. 2019 Mar 21;4(6). pii: 123879. doi: 10.1172/jci.insight.123879. eCollection 2019 Mar 21. PMID: 30730852 | PMC6483004

  33. Petz A, Grandoch M, Gorski DJ, Abrams M, Piroth MA, Schneckmann R, Homann S, Müller J, Hartwig S, Lehr S, Yamaguchi Y, Wight TN, Gorressen S, Ding Z, Kötter S, Krüger M, Heinen A, Kelm M, Gödecke A, Flögel U, Fischer JW. Cardiac Hyaluronan Synthesis Is Critically Involved in the Cardiac Macrophage Response and Promotes Healing After Ischemia Reperfusion Injury. Circ Res. 2019 Mar 27. doi: 10.1161/CIRCRESAHA.118.313285. PMID: 30916618

  34. Roan F, Obata-Ninomiya K, Ziegler SF. Epithelial cell-derived cytokines: more than just signaling the alarm. J Clin Invest. 2019 Apr 1;129(4):1441-1451. doi: 10.1172/JCI124606. Epub 2019 Apr 1. Review. PMID: 30932910 | PMC6436879

  35. Rojas OL, Pröbstel AK, Porfilio EA, Wang AA, Charabati M, Sun T, Lee DSW, Galicia G, Ramaglia V, Ward LA, Leung LYT, Najafi G, Khaleghi K, Garcillán B, Li A, Besla R, Naouar I, Cao EY, Chiaranunt P, Burrows K, Robinson HG, Allanach JR, Yam J, Luck H, Campbell DJ, Allman D, Brooks DG, Tomura M, Baumann R, Zamvil SS, Bar-Or A, Horwitz MS, Winer DA, Mortha A, Mackay F, Prat A, Osborne LC, Robbins C, Baranzini SE, Gommerman JL. Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10. Cell. 2019 Jan 24;176(3):610-624.e18. doi: 10.1016/j.cell.2018.11.035. Epub 2019 Jan 3. PMID: 30612739

  36. Rudulier CD, Tonti E, James E, Kwok WW, Larché M. Modulation of CRTh2 expression on allergen-specific T cells following peptide immunotherapy. Allergy. 2019 May 11. doi: 10.1111/all.13867. PMID: 31077596

  37. Ruff WE, Dehner C, Kim WJ, Pagovich O, Aguiar CL, Yu AT, Roth AS, Vieira SM, Kriegel C, Adeniyi O, Mulla MJ, Abrahams VM, Kwok WW, Nussinov R, Erkan D, Goodman AL, Kriegel MA. Pathogenic Autoreactive T and B Cells Cross-React with Mimotopes Expressed by a Common Human Gut Commensal to Trigger Autoimmunity. Cell Host Microbe. 2019 Jun 17. pii: S1931-3128(19)30248-3. doi: 10.1016/j.chom.2019.05.003. PMID: 31227334

  38. Schrock DC, Leddon SA, Hughson A, Miller J, Lacy-Hulbert A, Fowell DJ. Pivotal role for αV integrins in sustained Tfh support of the germinal center response for long-lived plasma cell generation. Proc Natl Acad Sci U S A. 2019 Feb 15. pii: 201809329. doi: 10.1073/pnas.1809329116. PMID: 30770452 | PMC6410787

  39. Sims EK, Bahnson HT, Nyalwidhe J, Haataja L, Davis AK, Speake C, DiMeglio LA, Blum J, Morris MA, Mirmira RG, Nadler J, Mastracci TL, Marcovina S, Qian WJ, Yi L, Swensen AC, Yip-Schneider M, Schmidt CM, Considine RV, Arvan P, Greenbaum CJ, Evans-Molina C.   Response to Comment on Sims et al. Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes. Diabetes Care. 2019 May;42(5):e85-e86. doi: 10.2337/dci19-0012. PMID: 31010952 | PMC6489112

  40. Stathopoulos P, Chastre A, Waters P, Irani S, Fichtner ML, Benotti ES, Guthridge JM, Seifert J, Nowak RJ, Buckner JH, Holers VM, James JA, Hafler DA, O'Connor KC. Autoantibodies against Neurologic Antigens in Nonneurologic Autoimmunity. J Immunol. 2019 Mar 1. pii: ji1801295. doi: 10.4049/jimmunol.1801295. PMID: 30824481 | PMC6452031

  41. Tam JM, Reedy JL, Lukason DP, Kuna SG, Acharya M, Khan NS, Negoro PE, Xu S, Ward RA, Feldman MB, Dutko RA, Jeffery JB, Sokolovska A, Wivagg CN, Lassen KG, Le Naour F, Matzaraki V, Garner EC, Xavier RJ, Kumar V, van de Veerdonk FL, Netea MG, Miranti CK, Mansour MK, Vyas JM. Tetraspanin CD82 Organizes Dectin-1 into Signaling Domains to Mediate Cellular Responses to Candida albicans. J Immunol. 2019 Jun 1;202(11):3256-3266. doi: 10.4049/jimmunol.1801384. PMID: 31010852 | PMC6529278

  42. Wambre E. The Use of pMHCII Tetramer Technology for the Identification and Characterization of CD4+ T Cells. Methods Mol Biol. 2019 (June) ;2020:153-164. doi: 10.1007/978-1-4939-9591-2_11. PMID: 31177498

  43. Wang T, Marken J, Chen J, Tran VB, Li QZ, Li M, Cerosaletti K, Elkon KB, Zeng X, Giltiay NV. High TLR7 Expression Drives the Expansion of CD19+CD24hiCD38hi Transitional B Cells and Autoantibody Production in SLE Patients. Front Immunol. 2019 Jun 4;10:1243. doi: 10.3389/fimmu.2019.01243. eCollection 2019. PMID: 31231380 | PMC6559307

  44. Wang Y, Sosinowski T, Novikov A, Crawford F, White J, Jin N, Liu Z, Zou J, Neau D, Davidson HW, Nakayama M, Kwok WW, Gapin L, Marrack P, Kappler JW, Dai S. How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes. Sci Immunol. 2019 Apr 5;4(34). pii: eaav7517. doi: 10.1126/sciimmunol.aav7517. PMID: 30952805

  45. Winters A, Bahnson HT, Ruczinski I, Boorgula MP, Malley C, Keramati AR, Chavan S, Larson D, Cerosaletti K, Sayre PH, Plaut M, Du Toit G, Lack G, Barnes KC, Nepom GT, Mathias RA; Immune Tolerance Network LEAP Study Team. The MALT1 locus and Peanut Avoidance in the Risk for Peanut Allergy. J Allergy Clin Immunol. 2019 Feb 27. pii: S0091-6749(19)30279-9. doi: 10.1016/j.jaci.2019.02.016. PMID: 30825465 | PMC6556406

  46. Wu D, Han JM, Yu X, Lam AJ, Hoeppli RE, Pesenacker AM, Huang Q, Chen V, Speake C, Yorke E, Nguyen N, Sampath S, Harris D, Levings MK. Characterization of regulatory T cells in obese omental adipose tissue in humans. Eur J Immunol. 2019 Feb;49(2):336-347. doi: 10.1002/eji.201847570. Epub 2019 Jan 8. PMID: 30566246

  47. Zhao LP, Papadopoulos GK, Kwok WW, Xu B, Kong M, Moustakas AK, Bondinas GP, Carlsson A, Elding-Larsson H, Ludvigsson J, Marcus C, Persson M, Samuelsson U, Wang R, Pyo CW, Nelson WC, Geraghty DE, Lernmark Å. Eleven Amino Acids of HLA-DRB1 and Fifteen Amino Acids of HLA-DRB3, 4 and 5 Include Potentially "Causal Residues" Responsible for the Risk of Childhood Type 1 Diabetes. Diabetes. 2019 May 24. pii: db190273. doi: 10.2337/db19-0273. PMID: 31127057