The following list highlights BRI's most recent publications. More extensive listings of publications are also included on scientist biography pages.

July - September 2016

  1. Ali R, Babad J, Follenzi A, Gebe JA, Brehm MA, Nepom GT, Shultz LD, Greiner DL, DiLorenzo TP. Genetically modified human CD4(+) T cells can be evaluated in vivo without lethal graft-versus-host disease. Immunology. 2016 Aug;148(4):339-51. doi: 10.1111/imm.12613. PMID: 27124592

  2. Asare AL, Carey VJ, Rotrosen D, Nepom GT. Clinical trial data access: Opening doors with TrialShare. J Allergy Clin Immunol. 2016 Sep;138(3):724-6. doi: 10.1016/j.jaci.2016.05.034. Epub 2016 Jul 12. PMID: 27474121

  3. Boucard-Jourdin M, Kugler D, Endale Ahanda ML, This S, De Calisto J, Zhang A, Mora JR, Stuart LM, Savill J, Lacy-Hulbert A, Paidassi H. β8 Integrin Expression and Activation of TGF-β by Intestinal Dendritic Cells Are Determined by Both Tissue Microenvironment and Cell Lineage. J Immunol. 2016 Sep 1;197(5):1968-78. doi: 10.4049/jimmunol.1600244. Epub 2016 Aug 1. PMID: 27481847

  4. Buechler MB, Akilesh HM, Hamerman JA. Cutting Edge: Direct Sensing of TLR7 Ligands and Type I IFN by the Common Myeloid Progenitor Promotes mTOR/PI3K-Dependent Emergency Myelopoiesis. J Immunol. 2016 Aug 26. pii: 1600813. PMID: 27566824

  5. Doedens JR, Jones WD, Hill K, Mason MJ, Gersuk VH, Mease PJ, Dall'Era M, Aranow C, Martin RW, Cohen SB, Fleischmann RM, Kivitz AJ, Burge DJ, Chaussabel D, Elkon KB, Posada JA. Blood-Borne RNA Correlates with Disease Activity and IFN-Stimulated Gene Expression in Systemic Lupus Erythematosus. J Immunol. 2016 Aug 17. pii: 1601142. PMID: 27534558

  6. Du F, Garg AV, Kosar K, Majumder S, Kugler DG, Mir GH, Maggio M, Henkel M, Lacy-Hulbert A, McGeachy MJ. Inflammatory Th17 Cells Express Integrin αvβ3 for Pathogenic Function. Cell Rep. 2016 Aug 2;16(5):1339-51. doi: 10.1016/j.celrep.2016.06.065. Epub 2016 Jul 21. PMID: 27452457

  7. Ettinger RA, Paz P, James EA, Gunasekera D, Aswad F, Thompson AR, Matthews DC, Pratt KP. T cells from three Hemophilia A subjects recognized the same HLA-restricted FVIII epitope with a narrow TCR repertoire. Blood. 2016 Jul 28. pii: blood-2015-11-682468. PMID: 27471234

  8. Gebe JA, Yadava K, Ruppert SM, Marshall P, Hill P, Falk BA, Sweere JM, Han H, Kaber G, Medina C, Mikecz K, Ziegler SF, Balaji S, Keswani SG, de Jesus Perez VA, Butte MJ, Nadeau K, Altemeier WA, Fanger N, Bollyky PL. Modified High Molecular Weight Hyaluronan Promotes Allergen-Specific Immune Tolerance. Am J Respir Cell Mol Biol. 2016 Sep 6. PMID: 27598620

  9. Hao W, Gitelman S, DiMeglio LA, Boulware D, Greenbaum CJ; Type 1 Diabetes TrialNet Study Group. Fall in C-Peptide During First 4 Years From Diagnosis of Type 1 Diabetes: Variable Relation to Age, HbA1c, and Insulin Dose. Diabetes Care. 2016 Jul 15. pii: dc160360. PMID: 27422577

  10. Hundhausen C, Roth A, Whalen E , Chen J, Schneider A, Long SA, Wei S, Rawlings R, Kinsman M, Evanko SP, Wight TN, Greenbaum CJ, Cerosaletti K, Buckner JH. Enhanced T cell responses to IL-6 in type 1 diabetes are associated with early clinical disease and increased IL-6 receptor expression. Sci Transl Med. 2016 Sep 14;8(356):356ra119. PMID: 27629486

  11. Johnson MC, Pierson ER, Spieker AJ, Nielsen AS, Posso S, Kita M, Buckner JH, Goverman JM. Distinct T cell signatures define subsets of patients with multiple sclerosis. Neurol Neuroimmunol Neuroinflamm. 2016 Aug 23;3(5):e278. doi: 10.1212/NXI.0000000000000278. eCollection 2016. PMID: 27606354

  12. Koch J, Lüdemann J, Spies R, Last M, Amemiya CT, Burmester T. 2016. Unusual diversity of myoglobin genes in the lungfish. Mol. Biol. Evol. pii: msw159. PMID: 27512111

  13. Muehling LM, Mai DT, Kwok WW, Heymann PW, Pomés A, Woodfolk JA. Circulating Memory CD4+ T Cells Target Conserved Epitopes of Rhinovirus Capsid Proteins and Respond Rapidly to Experimental Infection in Humans. J Immunol. 2016 Sep 2. pii: 1600663. PMID: 27591323

  14. Nelson JE, Roth CL, Wilson LA, Yates KP, Aouizerat B, Morgan-Stevenson V, Whalen E, Hoofnagle A, Mason M, Gersuk V, Yeh MM, Kowdley KV. Vitamin D Deficiency Is Associated With Increased Risk of Non-alcoholic Steatohepatitis in Adults With Non-alcoholic Fatty Liver Disease: Possible Role for MAPK and NF-κB? Am J Gastroenterol. 2016 Jun;111(6):852-63. doi: 10.1038/ajg.2016.51. Epub 2016 Mar 22. PMID: 27002799

  15. Nguyen H, James EA. Immune recognition of citrullinated epitopes. Immunology. 2016 Oct;149(2):131-8. doi: 10.1111/imm.12640. Epub 2016 Aug 17. Review. PMID: 27531825

  16. Nuttle X, Giannuzzi G, Duyzend MH, Schraiber JG, Narvaiza I, Sudmant PH, Penn O, Chiatante G, Malig M, Huddleston J, Benner C, Camponeschi F, Ciofi-Baffoni S, Stessman HA, Marchetto MC, Denman L, Harshman L, Baker C, Raja A, Penewit K, Janke N, Tang WJ, Ventura M, Banci L, Antonacci F, Akey JM, Amemiya CT, Gage FH, Reymond A, Eichler EE. Emergence of a Homo sapiens-specific gene family and chromosome 16p11.2 CNV susceptibility. Nature. 2016 Aug 11;536(7615):205-9. PMID: 27487209

  17. Piliponsky AM, Lahiri A, Truong P, Clauson M, Shubin NJ, Han H, Ziegler SF. Thymic Stromal Lymphopoietin Improves Survival and Reduces Inflammation in Sepsis. Am J Respir Cell Mol Biol. 2016 Aug;55(2):264-74. doi: 10.1165/rcmb.2015-0380OC. PMID: 26934097

  18. Presnell JS, Vandepas LE, Warren KJ, Swalla BJ, Amemiya CT, Browne WE. 2016. The Presence of a Functionally Tripartite Through-Gut in Ctenophora Has Implications for Metazoan Character Trait Evolution. Curr. Biol. 2016 Aug 24. pii: S0960-9822(16)30931-9. doi: 10.1016/j.cub.2016.08.019. PMID: 27568594

  19. Sparks JA, Chang SC, Deane KD, Gan RW, Kristen Demoruelle M, Feser ML, Moss L, Buckner JH, Keating RM, Costenbader KH, Gregersen PK, Weisman MH, Mikuls TR, O'Dell JR, Michael Holers V, Norris JM, Karlson EW. Associations of Smoking and Age With Inflammatory Joint Signs Among Unaffected First-Degree Relatives of Rheumatoid Arthritis Patients: Results From Studies of the Etiology of Rheumatoid Arthritis. Arthritis Rheumatol. 2016 Aug;68(8):1828-38. doi: 10.1002/art.39630. PMID: 26866831

  20. Sprouse ML, Blahnik G, Lee T, Tully N, Banerjee P, James EA, Redondo MJ, Bettini ML, Bettini M. Rapid identification and expression of human TCRs in retrogenic mice. J Immunol Methods. 2016 Aug 30. pii: S0022-1759(16)30167-3. doi: 10.1016/j.jim.2016.08.010. PMID: 27589924

  21. Stolley JM, Campbell DJ. A 33D1+ Dendritic Cell/Autoreactive CD4+ T Cell Circuit Maintains IL-2-Dependent Regulatory T Cells in the Spleen. J Immunol. 2016 Aug 26. pii: 1600974. PMID: 27566821

  22. Tam JM, Mansour MK, Acharya M, Sokolovska A, Timmons AK, Lacy-Hulbert A, Vyas JM. The Role of Autophagy-Related Proteins in Candida albicans Infections. Pathogens. 2016 Mar 29;5(2). pii: E34. doi: 10.3390/pathogens5020034. PMID: 27043636

  23. Thelen TD, Green RM, Ziegler SF. Acute blockade of IL-25 in a colitis associated colon cancer model leads to increased tumor burden. Sci Rep. 2016 May 11;6:25643. doi: 10.1038/srep25643. PMID: 27165713

  24. Tran TM, Jones MB, Ongoiba A, Bijker EM, Schats R, Venepally P, Skinner J, Doumbo S, Quinten E, Visser LG, Whalen E, Presnell S, O'Connell EM, Kayentao K, Doumbo OK, Chaussabel D, Lorenzi H, Nutman TB, Ottenhoff TH, Haks MC, Traore B, Kirkness EF, Sauerwein RW, Crompton PD. Transcriptomic evidence for modulation of host inflammatory responses during febrile Plasmodium falciparum malaria. Sci Rep. 2016 Aug 10;6:31291. doi: 10.1038/srep31291. PMID: 27506615

  25. Uchtenhagen H, Rims C, Blahnik G, Chow IT, Kwok WW, Buckner JH, James EA. Efficient ex vivo analysis of CD4+ T-cell responses using combinatorial HLA class II tetramer staining. Nat Commun. 2016 Aug 30;7:12614. doi: 10.1038/ncomms12614. PMID: 27571776

  26. Walker LS, Ziegler SZ, Becher B. Contemplating autoimmunity in the Aegean islands. Nat Immunol. 2016 Mar;17(3):218-20. doi: 10.1038/ni.3367. PMID: 26882250

  27. Ziegler SF. Division of labour by CD4(+) T helper cells. Nat Rev Immunol. 2016 Jul;16(7):403. doi: 10.1038/nri.2016.53. Epub 2016 May 3. PMID: 27140479


April - June 2016

  1. Acharya M, Sokolovska A, Tam JM, Conway KL, Stefani C, Raso F, Mukhopadhyay S, Feliu M, Paul E, Savill J, Hynes RO, Xavier RJ, Vyas JM, Stuart LM, Lacy-Hulbert A. αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells. Nat Commun. 2016 Mar 11;7:10917. doi: 10.1038/ncomms10917. PMID: 26965188

  2. Ali, R; Babad, J; Follenzi, A; Gebe, J; Brehm, M; Nepom, G; Shultz, L; Greiner, D; DiLorenzo, T. Genetically Modified Human CD4+ T Cells Can Be Evaluated In Vivo Without Lethal Graft Versus Host Disease.  Immunology. 2016 Apr 28. doi: 10.1111/imm.12613. PMID: 27124592

  3. Bryant SA, Herdy JR, Amemiya CT, Smith JJ. Characterization of Somatically-Eliminated Genes During Development of the Sea Lamprey (Petromyzon marinus). Mol Biol Evol. 2016 Jun 10. pii: msw104. PMID: 27288344

  4. Gan RW, Demoruelle MK, Deane KD, Weisman MH, Buckner JH, Gregersen PK, Mikuls TR, O'Dell JR, Keating RM, Fingerlin TE, Zerbe GO, Clare-Salzler MJ, Holers VM, Norris JM. Omega-3 fatty acids are associated with a lower prevalence of autoantibodies in shared epitope-positive subjects at risk for rheumatoid arthritis. Ann Rheum Dis. 2016 May 17. pii: annrheumdis-2016-209154. doi: 10.1136/annrheumdis-2016-209154. PMID: 27190099

  5. Glatigny S, Wagner CA, Bettelli E. Cutting Edge: Integrin α4 Is Required for Regulatory B Cell Control of Experimental Autoimmune Encephalomyelitis. J Immunol. 2016 May 1;196(9):3542-6. doi: 10.4049/jimmunol.1502614. PMID: 27016608

  6. Jackson SW, Jacobs HM, Arkatkar T, Dam EM, Scharping NE, Kolhatkar NS, Hou B, Buckner JH, Rawlings DJ. B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6. J Exp Med. 2016 May 2;213(5):733-50. doi: 10.1084/jem.20151724. PMID: 27069113

  7. Josberger EE, Hassanzadeh P, Deng Y, Sohn J, Rego M, Amemiya CT, Rolandi M. Proton conductivity in ampullae of Lorenzini jelly. Science Advances. 13 May 2016: Vol. 2, no. 5, e1600112 DOI: 10.1126/sciadv.1600112

  8. Karthikeyan K, Barker K, Tang Y, Kahn P, Wiktor P, Brunner A, Knabben V, Takulapalli B, Buckner J, Nepom G, LaBaer J, Qiu J. A contra capture protein array platform for studying post-translationally modified auto-antigenomes. Mol Cell Proteomics. 2016 May 2. pii: mcp.M115.057661. PMID: 27141097

  9. Kuipers HF, Nagy N, Ruppert SM, Sunkari VG, Marshall PL, Gebe JA, Ishak HD, Keswani SG, Bollyky J, Frymoyer AR, Wight TN, Steinman L, Bollyky PL. The Pharmacokinetics and Dosing of Oral 4-Methylumbelliferone for Inhibition of Hyaluronan Synthesis in Mice. Clin Exp Immunol. 2016 May 24. doi: 10.1111/cei.12815. PMID: 27218304

  10. Lorente E, Barriga A, Barnea E, Mir C, Gebe JA, Admon A, López D. Structural and nonstructural viral proteins are targets of T-helper immune response against human respiratory syncytial virus. Mol Cell Proteomics. 2016 Jun;15(6):2141-51. doi: 10.1074/mcp.M115.057356. PMID: 27090790

  11. Merrilees MJ, Zuo N, Evanko SP, Day AJ, Wight TN. G1 domain of versican regulates hyaluronan organization and the phenotype of cultured human dermal fibroblasts. J Histochem Cytochem. 2016 Jun;64(6):353-63. doi: 10.1369/0022155416643913. PMID: 27126822

  12. Pinckney A, Rigby MR, Keyes-Elstein L, Soppe CL, Nepom GT, Ehlers MR. Correlation Among Hypoglycemia, Glycemic Variability, and C-Peptide Preservation After Alefacept Therapy in Patients with Type 1 Diabetes Mellitus: Analysis of Data from the Immune Tolerance Network T1DAL Trial. Clin Ther. 2016 May 18. pii: S0149-2918(16)30266-1. doi: 10.1016/j.clinthera.2016.04.032. PMID: 27209482

  13. Reeves SR, Kaber G, Sheih A, Cheng G, Aronica MA, Merrilees MJ, Debley JS, Frevert CW, Ziegler SF, Wight TNSubepithelial accumulation of versican in a cockroach antigen-induced murine model of allergic asthma. J Histochem Cytochem. 2016 Jun;64(6):364-80. doi: 10.1369/0022155416642989. PMID: 27126823

  14. Rinchai D, Boughorbel S, Presnell S, Quinn C, Chaussabel D. A curated compendium of monocyte transcriptome datasets of relevance to human monocyte immunobiology research. F1000Res. 2016 Apr 25;5:291. doi: 10.12688/f1000research.8182.2. eCollection 2016. PMID: 27158452

  15. Scholz E, Mestre-Ferrer A, Daura X, García-Medel N, Carrascal M, James EA, Kwok WW, Canals F, Alvarez I. A comparative analysis of the peptide repertoires of HLA-DR molecules differentially associated to rheumatoid arthritis. Arthritis Rheumatol. 2016 May 9. doi: 10.1002/art.39736. PMID: 27158783

  16. Tam JM, Mansour MK, Acharya M, Sokolovska A, Timmons AK, Lacy-Hulbert A, Vyas JM. The Role of Autophagy-Related Proteins in Candida albicans Infections. Pathogens. 2016 Mar 29;5(2). pii: E34. doi: 10.3390/pathogens5020034. PMID: 27043636


January - March 2016

  1. Blazkova J, Boughorbel S, Presnell S, Quinn C, Chaussabel D. A curated transcriptome dataset collection to investigate the immunobiology of HIV infection. F1000Res. 2016 Mar 11;5:327. doi: 10.12688/f1000research.8204.1. eCollection 2016. PMID: 27134731

  2. Braasch I, Gehrke AR, Smith JJ, Kawasaki K, Manousaki T, Pasquier J, Amores A, Desvignes T, Batzel P, Catchen J, Berlin AM, Campbell MS, Barrell D, Martin KJ, Mulley JF, Ravi V, Lee AP, Nakamura T, Chalopin D, Fan S, Wcisel D, Cañestro C, Sydes J, Beaudry FE, Sun Y, Hertel J, Beam MJ, Fasold M, Ishiyama M, Johnson J, Kehr S, Lara M, Letaw JH, Litman GW, Litman RT, Mikami M, Ota T, Saha NR, Williams L, Stadler PF, Wang H, Taylor JS, Fontenot Q, Ferrara A, Searle SM, Aken B, Yandell M, Schneider I, Yoder JA, Volff JN, Meyer A, Amemiya CT, Venkatesh B, Holland PW, Guiguen Y, Bobe J, Shubin NH, Di Palma F, Alföldi J, Lindblad-Toh K, Postlethwait JH. The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nat Genet. 2016 Mar 7. doi: 10.1038/ng.3526. PMID: 26950095

  3. Buckner JH, Nepom GT. Obstacles and opportunities for targeting the effector T cell response in type 1 diabetes. J Autoimmun. 2016 Mar 3. pii: S0896-8411(16)30011-7. doi: 10.1016/j.jaut.2016.02.009. PMID: 26948997

  4. Clemente-Casares X, Blanco J, Ambalavanan P, Yamanouchi J, Singha S, Fandos C, Tsai S, Wang J, Garabatos N, Izquierdo C, Agrawal S, Keough MB, Yong VW, James EA, Moore A, Yang Y, Stratmann T, Serra P, Santamaria P. Expanding antigen-specific regulatory networks to treat autoimmunity. Nature. 2016 Feb 25;530(7591):434-40. doi: 10.1038/nature16962. Epub 2016 Feb 17. PMID: 26886799

  5. Eldredge LC, Treuting PM, Manicone AM, Ziegler SF, Parks WC, McGuire JK. CD11b(+) Mononuclear Cells Mitigate Hyperoxia-Induced Lung Injury in Neonatal Mice. Am J Respir Cell Mol Biol. 2016 Feb;54(2):273-83. PMID: 26192732

  6. Jackson SW, Jacobs HM, Arkatkar T, Dam EM, Scharping NE, Kolhatkar NS, Hou B, Buckner JH, Rawlings DJ. AI-18 B cell IFN-γ receptor signalling promotes autoimmune germinal centresvia cell-intrinsic induction of BCL-6. Lupus Sci Med 2016;3: doi:10.1136/lupus-2016-000179.18

  7. James EA, Gates TJ, LaFond RE, Yamamoto S, Ni C, Mai D, Gersuk VH, O'Brien K, Nguyen QA, Zeitner B, Lanteri MC, Norris PJ, Chaussabel D, Malhotra U, Kwok WW. Neuroinvasive West Nile Infection Elicits Elevated and Atypically Polarized T Cell Responses That Promote a Pathogenic Outcome. PLoS Pathog. 2016 Jan 21;12(1):e1005375. doi: 10.1371/journal.ppat.1005375. eCollection 2016 Jan. PMID: 26795118

  8. Kuipers HF, Rieck M, Gurevich I, Butte MJ, Negrin RS, Wight TN, Steinman L, Bollyky PL. Hyaluronan synthesis is necessary for autoreactive T cell trafficking, activation, and Th1 polarization. Proc Natl Acad Sci U S A. 113:1339-44, 2016. PMID: 26787861

  9. Lehmann-Werman R, Neiman D, Zemmour H, Moss J, Magenheim J, Vaknin-Dembinsky A, Rubertsson S, Nellgård B, Blennow K, Zetterberg H, Spalding K, Haller MJ, Wasserfall CH, Schatz DA, Greenbaum CJ, Dorrell C, Grompe M, Zick A, Hubert A, Maoz M, Fendrich V, Bartsch DK, Golan T, Ben Sasson SA, Zamir G, Razin A, Cedar H, Shapiro AM, Glaser B, Shemer R, Dor Y. Identification of tissue-specific cell death using methylation patterns of circulating DNA. Proc Nat’l Acad Sci USA, 2016 Mar 19. PMID: 26976580

  10. Lombardi V, Beuraud C, Neukirch C, Moussu H, Morizur L, Horiot S, Luce S, Wambre E, Linsley P, Chollet-Martin S, Baron-Bodo V, Aubier M, Moingeon P. Circulating innate lymphoid cells are differentially regulated in allergic and nonallergic subjects. J Allergy Clin Immunol. 2016 Mar 3. pii: S0091-6749(16)00187-1. doi: 10.1016/j.jaci.2015.12.1325. PMID: 26949057

  11. Lombardi V, Beuraud C, Neukirch C, Moussu H, Morizur L, Horiot S, Luce S, Wambre E, Linsley P, Chollet-Martin S, Baron-Bodo V, Aubier M, Moingeon P. Circulating innate lymphoid cells are differentially regulated in allergic and nonallergic subjects. J Allergy Clin Immunol. 2016 Mar 3. PMID: 26949057

  12. Marr AK, Boughorbel S, Presnell S, Quinn C, Chaussabel D, Kino T. A curated transcriptome dataset collection to investigate the development and differentiation of the human placenta and its associated pathologies. Version 2. F1000Res. 2016 Mar 9;5:305. doi: 10.12688/f1000research.8210.2. eCollection 2016. PMID: 27303626

  13. Meah FA, DiMeglio LA, Greenbaum CJ, Blum JS, Sosenko JM, Pugliese A, Geyer S, Xu P, Evans-Molina C; Type 1 Diabetes TrialNet Study Group. The relationship between BMI and insulin resistance and progression from single to multiple autoantibody positive and type 1 diabetes among TrialNet Pathways to Prevention participants. Diabetologia, 2016 Mar 19. PMID: 26995649

  14. Qin J, Fu S, Speake C, Greenbaum CJ, Odegard JM. NETosis-associated serum biomarkers are reduced in type11 diabetes in association with neutrophil count. Clin Exp Immunol, 2016 Mar 3. PMID: 26939803

  15. Rahman M, Boughorbel S, Presnell S, Quinn C, Cugno C, Chaussabel D, Marr N. A curated transcriptome dataset collection to investigate the functional programming of human hematopoietic cells in early life. F1000Res. 2016 Mar 30;5:414. doi: 10.12688/f1000research.8375.1. eCollection 2016. PMID: 27347375

  16. Raj P, Li Q-Z, Dozmorov I, Olsen NJ, Sivils K, Kelly J, James JA, Lauwerys B, Gregersen P, Cerosaletti K, Karp DR, Wakeland EK. GG-07 SLE risk haplotypes are associated with development of serologic autoimmunity in healthy individuals. Lupus Sci Med 2016;3: doi:10.1136/lupus-2016-000179.59

  17. Redondo MJ, Grant SF, Davis A, Greenbaum CJ; T1D Exchange Biobank. Dissecting heterogeneity in pediatric Type 1 diabetes: association of TCF7L2 rs7903146 TT and low-risk human leukocyte antigen (HLA) genotypes. Diabet Med 2016 Mar 30. PMID: 27027642

  18. Renand A, Robinson D, Kwok WW. Reply. J Allergy Clin Immunol. 2016 Mar 10. pii: S0091-6749(16)00196-2. doi: 10.1016/j.jaci.2015.11.046. PMID: 26971693

  19. Rinchai D, Boughorbel S, Presnell S, Quinn C, Chaussabel D. A compendium of monocyte transcriptome datasets to foster biomedical knowledge discovery. F1000Res. 2016 Mar 7;5:291. doi: 10.12688/f1000research.8182.1. eCollection 2016. PMID: 27158451

  20. Roan F, Stoklasek TA, Whalen E, Molitor JA, Bluestone JA, Buckner JH, Ziegler SF. CD4+ Group 1 Innate Lymphoid Cells (ILC) Form a Functionally Distinct ILC Subset That Is Increased in Systemic Sclerosis. J Immunol. 2016 Mar 1;196(5):2051-62. PMID: 26826243

  21. Spindler MP, Ho AM, Tridgell D, McCulloch-Olson M, Gersuk V, Ni C, Greenbaum CJ, Sanda S. Acute hyperglycemia impairs IL-6 expression in humans. Immun Inflamm Dis. 2016 Jan 19;4(1):91-7. eCollection 2016 Mar. PMID: 27042306

  22. Thompson LJ, Lai JF, Valladao AC, Thelen TD, Urry ZL, Ziegler SF. Conditioning of naive CD4(+) T cells for enhanced peripheral Foxp3 induction by nonspecific bystander inflammation. Nat Immunol. 2016 Mar;17(3):297-303. PMID: 26752376

  23. Vendrame F, Hopfner YY, Diamantopoulos S, Virdi SK, Allende G, Snowhite IV, Reijonen HK, Chen L, Ruiz P, Ciancio G, Hutton JC, Messinger S, Burke GW 3rd, Pugliese A. Risk Factors for Type 1 Diabetes Recurrence in Immunosuppressed Recipients of Simultaneous Pancreas-Kidney Transplants. Am J Transplant. 2016 Jan;16(1):235-45. doi: 10.1111/ajt.13426. Epub 2015 Aug 28. PMID: 26317167

  24. Wherrett DK, Chiang JL, Delamater AM, DiMeglio LA, Gitelman SE, Gottlieb PA, Herold KC, Lovell DJ, Orchard TJ, Ryan CM, Schatz DA, Wendler DS, Greenbaum CJ; Type 1 Diabetes TrialNet Study Group. Defining pathways for development of disease-modifying therapies in children with type 1 diabetes: a consensus report. Diabetes Care, 2015 Oct;38(10):1975-85. Review. PMID: 26404927


October - December 2015

  1. Bluestone JA, Buckner JH, Fitch M, Gitelman SE, Gupta S, Hellerstein MK, Herold KC, Lares A, Lee MR, Li K, Liu W, Long SA, Masiello LM, Nguyen V, Putnam AL, Rieck M, Sayre PH, Tang Q. Type 1 diabetes immunotherapy using polyclonal regulatory T cells. Sci Transl Med. 2015 Nov 25;7(315):315ra189. PMID: 26606968

  2. Cabrera SM, Wang X, Chen YG, Jia S, Kaldunski ML, Greenbaum CJ; Type 1 Diabetes TrialNet Canakinumab Study Group, Mandrup-Poulsen T; AIDA Study Group, Hessner MJ. Interleukin-1 antagonism moderates the inflammatory state associated with Type 1 diabetes during clinical trials conducted at disease onset. Eur J Immunol, 2015 Dec 22. PMID: 26692253

  3. Chujo D, Nguyen T-S, Foucat E, Blankenship D, Banchereau J, Nepom GT, Chaussabel D, Ueno H. Adult-onset type 1 diabetes patients display decreased IGRP-specific Tr1 cells in blood. Clin Immunol. 2015 Dec;161(2):270-7. doi: 10.1016/j.clim.2015.08.014. PMID: 26341315

  4. Gan RW, Young KA, Zerbe GO, Demoruelle MK, Weisman MH, Buckner JH, Gregersen PK, Mikuls TR, O'Dell JR, Keating RM, Clare-Salzler MJ, Deane KD, Holers VM, Norris JM. Lower omega-3 fatty acids are associated with the presence of anti-cyclic citrullinated peptide autoantibodies in a population at risk for future rheumatoid arthritis: a nested case-control study. Rheumatology (Oxford). 2016 Feb;55(2):367-76. doi: 10.1093/rheumatology/kev266. Epub 2015 Sep 13. PMID: 26370400

  5. Ge Yan, Onengut-Gumuscu S, Quinlan AR, Mackey AJ, Wright JA, Buckner JH, Habib T, Rich SS, Concannon P. Targeted Deep Sequencing in Multiple-Affected Sibships of European Ancestry Identifies Rare Deleterious Variants in PTPN22 that Confer Risk for Type 1 Diabetes. Diabetes. 2015 Dec 2. pii: db150322. [Epub ahead of print]. PMID: 26631741

  6. Gill RG, Pagni PP, Kufper T, Wasserfall CH, Deng S, Posgai A, Manenkova Y, Hani AB, Straub L, Bernstein P, Atkinson MA, Herold KC, von Herrath M, Staeva T, Ehlers MR, Nepom GT. A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice. Diabetes. 2015 Dec 30. pii: db150492. PMID: 26718498

  7. Hamerman JA, Pottle J, Ni M, He Y, Zhang ZY, Buckner JH. Negative regulation of TLR signaling in myeloid cells-implications for autoimmune diseases. Immunol Rev. 2016 Jan;269(1):212-27. doi: 10.1111/imr.12381. PMID: 26683155

  8. Han CY, Tang C, Guevara ME, Wei H, Wietecha T, Shao B, Subramanian S, Omer M, Wang S, O'Brien KD, Marcovina SM, Wight TN, Vaisar T, de Beer MC, de Beer FC, Osborne WR, Elkon KB, Chait A. Serum amyloid A impairs the antiinflammatory properties of HDL. J Clin Invest. 2016 Jan 4;126(1):266-81. doi: 10.1172/JCI83475. Epub 2015 Dec 7. PMID: 26642365

  9. Hinz D, Seumois G, Gholami AM, Greenbaum JA, Lane J, White B, Broide DH, Schulten V, Sidney J, Bakhru P, Oseroff C, Wambre E, James EA, Kwok WW, Peters B, Vijayanand P, Sette A. Lack of allergy to timothy grass pollen is not a passive phenomenon but associated with allergen-specific modulation of immune reactivity. Clin Exp Allergy. 2015 Dec 14. doi: 10.1111/cea.12692. PMID: 26662458

  10. Hu JH, Wei H, Jaffe M, Airhart N, Du L, Angelov SN, Yan J, Allen JK, Kang I, Wight TN, Fox K, Smith A, Enstrom R, Dichek DA. Postnatal Deletion of the Type II Transforming Growth Factor-β Receptor in Smooth Muscle Cells Causes Severe Aortopathy in Mice. Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2647-56. doi: 10.1161/ATVBAHA.115.306573. Epub 2015 Oct 22. PMID: 26494233

  11. Insel RA, Dunne JL, Atkinson MA, Chiang JL, Dabelea D, Gottlieb PA, Greenbaum CJ, Herold KC, Krischer JP, Lernmark Å, Ratner RE, Rewers MJ, Schatz DA, SKlyer JS, Sosenko JM, Ziegler AG. Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association. Diabetes Care, 2015 Oct;38(10):1964-74. Review. PMID: 26404926

  12. Keire PA, Bressler SL, Mulvihill ER, Starcher BC, Kang I, Wight TN. Inhibition of versican expression by siRNA facilitates tropoelastin synthesis and elastic fiber formation by human SK-LMS-1 leiomyosarcoma smooth muscle cells in vitro and in vivo. Matrix Biol. 2015 Dec 23. pii: S0945-053X(15)30013-5. doi: 10.1016/j.matbio.2015.12.010. PMID: 26723257

  13. Lord JD. Promises and paradoxes of regulatory T cells in inflammatory bowel disease. World J Gastroenterol. 2015 Oct 28;21(40):11236-45. doi: 10.3748/wjg.v21.i40.11236. PMID: 26523099

  14. Marré ML, James EA, Piganelli JD. β cell ER stress and the implications for immunogenicity in type 1 diabetes. Front Cell Dev Biol. 2015 Oct 27;3:67. doi: 10.3389/fcell.2015.00067. eCollection 2015. PMID: 26579520

  15. Odegard JM, Nepom GT, and Wambre E. Biomarkers for antigen immunotherapy in allergy and type 1 diabetes. Clin Immunol. 2015 Nov;161(1):44-50. doi: 10.1016/j.clim.2015.05.023. PMID: 26122171

  16. Odegard JM, Nepom GT, Wambre E. Biomarkers for antigen immunotherapy in allergy and type 1 diabetes. Clin Immunol. 2015 Nov;161(1):44-50. doi: 10.1016/j.clim.2015.05.023. PMID: 26122171

  17. Pugliese A, Boulward D, Yu L, Babu S, Steck AK, Becker D, Rodriguez H, DiMeglio L, Evans-Molean C, Harrison LC, Schatz D, Palmer JP, Greenbaum CJ, Eisenbarth GS, Sosenko JM; Type 1 Diabetes TrialNet Study Group. The HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 haplotype protects autoantibody-positive relatives from type 1 diabetes throughout the stages of disease progression. Diabetes, 2016 Jan 28. PMID: 26822082

  18. Stuart LM, Lacy-Hulbert A. De-Mst-ifying microbicidal killing. Nat Immunol. 2015 Oct 20;16(11):1107-8. doi: 10.1038/ni.3291. PMID: 26482969

  19. Wambre E. Effect of allergen-specific immunotherapy on CD4+ T cells. Curr Opin Allergy Clin Immunol. 2015 Dec;15(6):581-7. doi: 10.1097/ACI.0000000000000216. PMID: 26509663


July - September 2015

  1. Arbelaez CA, Glatigny S, Duhen R, Eberl G, Oukka M, Bettelli E. IL-7/IL-7 Receptor Signaling Differentially Affects Effector CD4+ T Cell Subsets Involved in Experimental Autoimmune Encephalomyelitis. J Immunol. 2015 Sep 1;195(5):1974-83. doi: 10.4049/jimmunol.1403135. Epub 2015 Jul 29. PMID: 26223651

  2. Buechler MB, Gessay GM, Srivastava S, Campbell DJ, Hamerman JA. Hematopoietic and nonhematopoietic cells promote Type I interferon- and TLR7-dependent monocytosis during low-dose LCMV infection. Eur J Immunol. 2015 Aug 19. PMID: 26289159

  3. Eldredge LC, Treuting PM, Manicone AM, Ziegler SF, Parks WC, McGuire JK. CD11b+ Mononuclear Cells Mitigate Hyperoxia-induced Lung Injury in Neonatal Mice. Am J Respir Cell Mol Biol. 2015 Jul 20. [Epub ahead of print] PMID: 26192732

  4. Harten IA, Olive M, Wight TN. Vascular disease in Hutchinson Gilford progeria syndrome and aging: Common phenotypes and potential mechanisms. In: Handbook of the Biology of Aging, Eighth Edition.  Kaeberlein MR, Martin GM eds.  Amsterdam: Elsevier, 2016. PMID: n/a

  5. Hull RL, Bogdani M, Nagy N, Johnson PY, Wight TN. Hyaluronan: A Mediator of Islet Dysfunction and Destruction in Diabetes? J Histochem Cytochem. 2015 Aug;63(8):592-603. doi: 10.1369/0022155415576542. PMID: 26216136

  6. Kang I, Barth JL, Sproul EP, Yoon DW, Braun KR, Argraves WS, Wight TN. Expression of V3 Versican by Rat Arterial Smooth Muscle Cells Promotes Differentiated and Anti-inflammatory Phenotypes. J Biol Chem. 2015 Aug 28;290(35):21629-41. doi: 10.1074/jbc.M115.657486. Epub 2015 Jul 7. PMID: 26152723

  7. Kijas AW, Lim YC, Bolderson E, Cerosaletti K, Gatei M, Jakob B, Tobias F, Taucher-Scholz G, Gueven N, Oakley G, Concannon P, Wolvetang E, Khanna KK, Wiesmüller L, Lavin MF. ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1. Nucleic Acids Res. 2015 Aug 3. pii: gkv754. [Epub ahead of print] PMID: 26240375

  8. Kwok WW. Modulation of Peanut-specific humoral and cellular responses pre- and post-oral immunotherapy. Clin Exp Allergy. 2015 Jul;45(7):1146-9. doi: 10.1111/cea.12552. PMID: 26082305

  9. Linsley PS, Chaussabel D, Speake C. The Relationship of Immune Cell Signatures to Patient Survival Varies within and between Tumor Types. PLoS One. 2015 Sep 23;10(9):e0138726. doi: 10.1371/journal.pone.0138726. eCollection 2015. PubMed PMID: 26398410

  10. Lord JD, Shows DM, Chen J, Thirlby RC. Human Blood and Mucosal Regulatory T Cells Express Activation Markers and Inhibitory Receptors in Inflammatory Bowel Disease. PLoS One. 2015 Aug 25;10(8):e0136485. doi: 10.1371/journal.pone.0136485. eCollection 2015. PMID: 26305224

  11. McGinty JW, Marré ML, Bajzik V, Piganelli JD, James EA. T Cell Epitopes and Post-Translationally Modified Epitopes in Type 1 Diabetes. Curr Diab Rep. 2015 Nov;15(11):90. doi: 10.1007/s11892-015-0657-7. PMID: 26370701

  12. Nagy N, Kaber G, Johnson PY, Gebe JA, Preisinger A, Falk BA, Sunkari VG, Gooden MD, Vernon RB, Bogdani M, Kuipers HF, Day AJ, Campbell DJ, Wight TN, Bollyky PL. Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis. J Clin Invest. 2015 Sep 14. pii: 79271. PMID: 26368307

  13. Rawlings DJ, Dai X, Buckner JH. The role of PTPN22 risk variant in the development of autoimmunity: finding common ground between mouse and human. J Immunol. 2015 Apr 1;194(7):2977-84. doi: 10.4049/jimmunol.1403034. PMID: 25795788

  14. Renand A, Archila LD, McGinty J, Wambre E, Robinson D, Hales BJ, Thomas WR, Kwok WW. Chronic cat allergen exposure induces a TH2 cell-dependent IgG4 response related to low sensitization. J Allergy Clin Immunol. 2015 Sep 11. pii: S0091-6749(15)01091-X. doi: 10.1016/j.jaci.2015.07.031. [Epub ahead of print] PMID: 26371841

  15. Rigby MR, Harris KM, Pinckney A, DiMeglio LA, Rendell MS, Felner EI, Dostou JM, Gitelman SE, Griffin KJ, Tsalikian E, Gottlieb PA, Greenbaum CJ, Sherry NA, Moore WV, Monzavi R, Willi SM, Raskin P, Keyes-Elstein L, Long SA, Kanaparthi S, Lim N, Phippard D, Soppe CL, Fitzgibbon ML, McNamara J, Nepom GT, Ehlers MR, Immune Tolerance Network (ITN). Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients. J Clin Invest. 2015 Aug 3;125(8):3285-96. doi: 10.1172/JCI81722. Epub 2015 Jul 20. PMID: 26193635

  16. Ruppert SM, Falk BA, Long SA, Bollyky PL. Regulatory T cells Resist Cyclosporin-Induced Cell Death Via CD44-mediated Signaling Pathways. International Journal of Cell Biology. vol. 2015, Article ID 614297, 10 pages, 2015. doi:10.1155/2015/614297.

  17. Tacchi L, Larragoite ET, Muñoz P, Amemiya CT, Salinas I. African Lungfish Reveal the Evolutionary Origins of Organized Mucosal Lymphoid Tissue in Vertebrates. Curr Biol. 2015 Sep 2. pii: S0960-9822(15)00934-3. doi: 10.1016/j.cub.2015.07.066. [Epub ahead of print].  PMID: 26344090

  18. Tampella G, Kerns HM, Niu D, Singh S, Khim S, Bosch KA, Garrett ME, Moguche A, Evans E, Browning B, Jahan TA, Nacht M, Wolf-Yadlin A, Plebani A, Hamerman JA, Rawlings DJ, James RG. The Tec Kinase-Regulated Phosphoproteome Reveals a Mechanism for the Regulation of Inhibitory Signals in Murine Macrophages. J Immunol. 2015 Jul 1;195(1):246-56. doi: 10.4049/jimmunol.1403238. Epub 2015 May 29. PMID: 26026062

  19. Tang W, Cui D, Jiang L, Zhao L, Qian W, Long SA, Xu K. Association of common polymorphisms in the IL2RA gene with type 1 diabetes: evidence of 32,646 individuals from 10 independent studies. J Cell Mol Med. 2015 Aug 7. doi: 10.1111/jcmm.12642. [Epub ahead of print]. PMID: 26249556

  20. Zhang M, Yu G, Chan B, Pearson JT, Rathanaswami P, Delaney J, Ching Lim A, Babcook J, Hsu H, Gavin MA. Interleukin-21 Receptor Blockade Inhibits Secondary Humoral Responses and Halts the Progression of Preestablished Disease in the (NZB × NZW)F1 Systemic Lupus Erythematosus Model. Arthritis Rheumatol. 2015 Oct;67(10):2723-31. doi: 10.1002/art.39233. PMID: 26097207

April - June 2015

  1. Alvarez I, Collado JA, Colobran R, Carrascal M, Ciudad MT, Canals F, James EA, Kwok WW, Gärtner M, Kyewski B, Pujol-Borrell R, Jaraquemada D. Central T cell tolerance: Identification of tissue-restricted autoantigens in the thymus HLA-DR peptidome. J Autoimmun. 2015 Jun;60:12-9. doi: 10.1016/j.jaut.2015.03.004. Epub 2015 Apr 21. PMID: 25911201

  2. Cao Y, Goods BA, Raddassi K, Nepom GT, Kwok WW, Love JC, Hafler DA. Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis. Sci Transl Med. 2015 May 13;7(287):287ra74. doi: 10.1126/scitranslmed.aaa8038. PMID: 25972006

  3. Holgersen K, Kutlu B, Fox B, Serikawa K, Lord J, Hansen AK, Holm TL. High-resolution gene expression profiling using RNA sequencing in patients with inflammatory bowel disease and in mouse models of colitis. J Crohns Colitis. 2015 Jun;9(6):492-506. PMID: 25795566

  4. Kikuchi S, Kenagy RD, Gao L, Wight TN, Azuma N, Sobel M, Clowes AW. Surgical marking pen dye inhibits saphenous vein cell proliferation and migration in saphenous vein graft tissue. J Vasc Surg. 2015 Apr 30. pii: S0741-5214(14)01899-0. doi: 10.1016/j.jvs.2014.10.017. PMID: 25935273

  5. Miller HC, O'Meally D, Ezaz T, Amemiya CT, Marshall-Graves JA, and Edwards S. Major Histocompatibility Complex Genes Map to Two Chromosomes in an Evolutionarily Ancient Reptile, the Tuatara Sphenodon punctatus. G3 (Bethesda). 2015 May 7. pii: g3.115.017467. doi: 10.1534/g3.115.017467. PMID: 25953959

  6. Otsuka F, Kramer MC, Woudstra P, Yahagi K, Ladich E, Finn AV, de Winter RJ, Kolodgie FD, Wight TN, Davis HR, Joner M, Virmani R. Natural progression of atherosclerosis from pathologic intimal thickening to late fibroatheroma in human coronary arteries: A pathology study. Atherosclerosis. 2015 May 19. pii: S0021-9150(15)01312-X. doi: 10.1016/j.atherosclerosis.2015.05.011. PMID: 26058741

  7. Wilson HM, Welikson RE, Luo J, Kean TJ, Cao B, Dennis JE, Allen MD. Can Cytoprotective Cobalt Protoporphyrin Protect Skeletal Muscle and Muscle-derived Stem Cells From Ischemic Injury? Clin Orthop Relat Res. 2015 Jun 13. PMID: 26070773

From January - March 2015

  1. Archila LD, Jeong D, Pascal M, Bartra J, Juan M, Robinson D, Farrington ML, Kwok WW. Jug r 2-reactive CD4+ T cells have a dominant immune role in walnut allergy. J Allergy Clin Immunol. 2015 Mar 13. pii: S0091-6749(15)00169-4. doi: 10.1016/j.jaci.2015.01.029. PMID: 25772597

  2. Bollyky JB, Xu P, Butte AJ, Wilson DM, Beam CA, Greenbaum CJ; the type 1 Diabetes TrialNet Study Group. Heterogeneity in recent onset type 1 diabetes – a clinical trial perspective. Diabetes Metab Res Rev, 2015 Feb 17, doi: 10.1002/dmrr.2643. PMID: 25689602

  3. Du Toit G, Roberts G, Sayre PH, Bahnson HT, Radulovic S, Santos AF, Brough HA, Phippard D, Basting M, Feeney M, Turcanu V, Sever ML, Gomez Lorenzo M, Plaut M, Lack G; LEAP Study Team. Randomized trial of peanut consumption in infants at risk for peanut allergy. N Engl J Med. 2015 Feb 26;372(9):803-13. doi: 10.1056/NEJMoa1414850. Epub 2015 Feb 23. PMID: 25705822

  4. Gan RW, Deane KD, Zerbe GO, Demoruelle MK, Weisman MH, Buckner JH, Gregersen PK, Mikuls TR, O'Dell JR, Keating RM, Holers VM, Norris JM. Relationship between air pollution and positivity of RA-related autoantibodies in individuals without established RA: a report on SERA. Ann Rheum Dis. 2013 Dec;72(12):2002-5. doi: 10.1136/annrheumdis-2012-202949. Epub 2013 Apr 9. PMID: 23572338

  5. Glatigny S, Duhen R, Arbelaez C, Kumari S, Bettelli E. Integrin alpha L controls the homing of regulatory T cells during CNS autoimmunity in the absence of integrin alpha 4. Sci Rep. 2015 Jan 16;5:7834. doi: 10.1038/srep07834. PMID: 25592296

  6. Gunasekera D, Ettinger RA, Nakaya Fletcher S, James EA, Liu M, Barrett JC, Withycombe J, Matthews DC, Epstein MS, Hughes RJ, Pratt KP. Factor VIII gene variants and inhibitor risk in African American hemophilia A patients. Blood. 2015 Jan 23. pii: blood-2014-09-599365. PMID: 25617427

  7. Hao W, Greenbaum CJ, Krischer JP, Cuthbertson D, Marks JB, Palmer JP. The Effect of DPT-1 Intravenous Insulin Infusion and Daily Subcutaneous Insulin on Endogenous Insulin Secretion and Postprandial Glucose Tolerance. Diabetes Care, 2015 Feb 26, PMID: 25720600

  8. Järveläinen H, Sainio A, Wight TN. Pivotal role for decorin in angiogenesis. Matrix Biol. 2015 Feb 7. pii: S0945-053X(15)00037-2. doi: 10.1016/j.matbio.2015.01.023. PMID: 25661523

  9. Lee HS, Cheerathodi M, Chaki SP, Reyes SB, Zheng Y, Lu Z, DerMardirossian C, Lacy-Hulbert A, Rivera GM, McCarty JH. PTP-PEST and β8 Integrin Control Spatiotemporal Patterns of RhoGDI1 Activation in Migrating Cells. Mol Cell Biol. 2015 Feb 9. pii: MCB.00112-15. PubMed PMID: 25666508.

  10. Lord S, Greenbaum CJ. Disease modifying therapies in type 1 diabetes: Where have we been, and where are we going?. Pharma Res, 2015, March 11. doi:10.1016/j.phrs.2015.02.002. PMID: 25771310

  11. Nagy N, Kuipers HF, Frymoyer AR, Ishak HD, Bollyky JB, Wight TN, Bollyky PL. 4-Methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy in inflammation, autoimmunity, and cancer. Front Immunol. 6:123, 2015. doi: 10.3389/fimmu.2015.00123. PMID: Unknown

  12. Rosenzwajg M, Churlaud G, Mallone R, Six A, Dérian N, Chaara W, Lorenzon R, Long SA, Buckner JH, Afonso G, Pham HP, Hartemann A, Yu A, Pugliese A, Malek TR, Klatzmann D. Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients. J Autoimmun. 2015 Jan 26. pii: S0896-8411(15)00002-5. doi: 10.1016/j.jaut.2015.01.001. PMID: 25634360

  13. Savar A, Acin S, Gonzalez CL, El-Sawy T, Mejia O, Li Z, Esmaeli B, Lacy-Hulbert A, El-Naggar AK, McCarty JH, Caulin C. Loss of epithelial p53 and αv integrin cooperate through Akt to induce squamous cell carcinoma yet prevent remodeling of the tumor microenvironment. Oncogene. 2015 Jan 22;34(4):516-24. doi: 10.1038/onc.2013.585. Epub 2014 Jan 27. PMID: 24469034.

  14. Sosenko JM, Skyler JS, Beam CA, Boulware D, Mahon JL, Krischer JP, Greenbaum CJ, Rafkin LE, Matheson D, Herold KC, Palmer JP; and the Type 1 Diabetes TrialNet and Diabetes Prevention Trial-Type 1 Study Groups. The Development and Utiity of a Novel Scale That Quantifies the Glycemic Progression Toward Type 1 Diabetes Over 6 Months. Diabetes Care, 2015 Mar 10. PMID: 25758770

  15. Sosenko JM, Skyler JS, DiMeglio LA, Beam CA, Krischer JP, Greenbaum CJ, Boulware D, Rafkin LE, Matheson D, Herold KC, Mahon J, Palmer JP; Type 1 Diabetes TrialNet Study Group; Diabetes Prevention trial Type 1 Study Group. A new approach for diagnosing type 1 diabetes in autoantibody-positive individuals based on prediction and natural history. Diabetes Care, 2015 Feb;38(2):271-6 doi: 10.2337/dc14-1813. PMID: 25519451

  16. Tang WJ, Fernandez JG, Sohn JJ, Amemiya CT. Chitin is endogenously produced in vertebrates. Curr Biol. 2015 Mar 30;25(7):897-900. doi: 10.1016/j.cub.2015.01.058. Epub 2015 Mar 12. PMID: 25772447

From October - December 2014

  1. Antonacci F, Dennis MY, Huddleston J, Sudmant PH, Steinberg KM, Rosenfeld JA, Miroballo M, Graves TA, Vives L, Malig M, Denman L, Raja A, Stuart A, Tang J, Munson B, Shaffer LG, Amemiya CT, Wilson RK, Eichler EE. Palindromic GOLGA8 core duplicons promote chromosome 15q13.3 microdeletion and evolutionary instability. Nat Genet. 2014 Dec;46(12):1293-302. doi: 10.1038/ng.3120. PMID: 25326701

  2. Bogdani M, Korpos E, Simeonovic CJ, Parish CR, Sorokin L, Wight TN. Extracellular matrix components in the pathogenesis of type 1 diabetes. Curr Diab Rep. 2014 Dec;14(12):552. doi: 10.1007/s11892-014-0552-7. PMID: 25344787

  3. Bogdani M, Simeonovic C, Nagy N, Johnson PY, Chan CK, Wight TN. The detection of glycosaminoglycans in pancreatic islets and lymphoid tissues. Methods Mol Biol. 2015;1229:413-30. doi: 10.1007/978-1-4939-1714-3_32. PMID: 25325969

  4. Chow IT, Yang J, Gates TJ, James EA, Mai DT, Greenbaum C, Kwok WW. Assessment of CD4+ T cell responses to glutamic acid decarboxylase 65 using DQ8 tetramers reveals a pathogenic role of GAD65 121-140 and GAD65 250-266 in T1D development. PLoS One. 2014 Nov 18;9(11):e112882. doi: 10.1371/journal.pone.0112882. eCollection 2014. PMID: 25405480

  5. Davis AK, DuBose SN, Haller MJ, Miller KM, DiMeglio LA, Bethin KE, Goland RS, Greenberg EM, Liljenquist DR, Ahmann AJ, Marcovina SM, Peters AL, Beck RW, Greenbaum CJ; for the T1D Exchange Clinic Network. Prevalence of Detectable C-peptide According to Age at Diagnosis and Duration of Type 1 Diabetes. Diabetes Care. 2014 Dec 17. pii: DC_141952. PMID: 25519448

  6. Evanko SP, Potter-Perigo S, Petty LJ, Workman GA, Wight TN. Hyaluronan Controls the Deposition of Fibronectin and Collagen and Modulates TGF-β1 Induction of Lung Myofibroblasts. Matrix Biol. 2014 Dec 27. pii: S0945-053X(14)00222-4. doi: 10.1016/j.matbio.2014.12.001. PMID: 25549589

  7. Han H, Thelen TD, Comeau MR, Ziegler SF. Thymic stromal lymphopoietin-mediated epicutaneous inflammation promotes acute diarrhea and anaphylaxis. J Clin Invest. 2014 Dec 1;124(12):5442-52. doi: 10.1172/JCI77798. Epub 2014 Nov 3. PMID: 25365222

  8. Keire PA, Bressler SL, Lemire JM, Edris B, Rubin BP, Rahmani M, McManus BM, van de Rijn M, Wight TN. A role for versican in the development of leiomyosarcoma. J Biol Chem. 2014 Dec 5;289(49):34089-103. doi: 10.1074/jbc.M114.607168. Epub 2014 Oct 15. PMID: 25320080

  9. Lo Kuan E, Ziegler SF. Thymic stromal lymphopoietin and cancer. J Immunol. 2014 Nov 1;193(9):4283-8. doi: 10.4049/jimmunol.1400864. PMID: 25326546

  10. Lord J, Chen J, Thirlby RC, Sherwood AM, Carlson CS. T-cell Receptor Sequencing Reveals the Clonal Diversity and Overlap of Colonic Effector and FOXP3+ T Cells in Ulcerative Colitis. Inflamm Bowel Dis. 2015 Jan;21(1):19-30. doi: 10.1097/MIB.0000000000000242. PMID: 25437819

  11. Mikacenic C, Schneider A, Radella F, Buckner JH, Wurfel MM. Cutting Edge: Genetic Variation in TLR1 Is Associated with Pam3CSK4-Induced Effector T Cell Resistance to Regulatory T Cell Suppression. J Immunol. 2014 Dec 15;193(12):5786-90. doi: 10.4049/jimmunol.1401185. Epub 2014 Nov 5. PMID: 25378593

  12. Peters A, Burkett PR, Sobel RA, Buckley CD, Watson SP, Bettelli E, Kuchroo VK. Podoplanin negatively regulates CD4+ effector T cell responses. J Clin Invest. 2014 Nov 21. pii: 74685. doi: 10.1172/JCI74685. PMID: 25415436

From July - September 2014

  1. Amemiya CT, Dorrington R, Meyer A. The coelacanth and its genome. J Exp Zool B Mol Dev Evol. 2014 Sep;322(6):317-21. doi: 10.1002/jez.b.22583. Epub 2014 Jul 25. PMID: 25059403

  2. Brawand D, Wagner CE, Li YI, Malinsky M, Keller I, Fan S, Simakov O, Ng AY, Lim ZW, Bezault E, Turner-Maier J, Johnson J, Alcazar R, Noh HJ, Russell P, Aken B, Alföldi J, Amemiya CT, Azzouzi N, Baroiller JF, Barloy-Hubler F, Berlin A, Bloomquist R, Carleton KL, Conte MA, D'Cotta H, Eshel O, Gaffney L, Galibert F, Gante HF, Gnerre S, Greuter L, Guyon R, Haddad NS, Haerty W, Harris RM, Hofmann HA, Hourlier T, Hulata G, Jaffe DB, Lara M, Lee AP, MacCallum I, Mwaiko S, Nikaido M, Nishihara H, Ozouf-Costaz C, Penman DJ, Przybylski D, Rakotomanga M, Renn SC, Ribeiro FJ, Ron M, Salzburger W, Sanchez-Pulido L, Santos ME, Searle S, Sharpe T, Swofford R, Tan FJ, Williams L, Young S, Yin S, Okada N, Kocher TD, Miska EA, Lander ES, Venkatesh B, Fernald RD, Meyer A, Ponting CP, Streelman JT, Lindblad-Toh K, Seehausen O, Di Palma F. The genomic substrate for adaptive radiation in African cichlid fish. Nature. 2014 Sep 18;513(7518):375-81. doi: 10.1038/nature13726. Epub 2014 Sep 3. PMID: 25186727

  3. Chang MY, Tanino Y, Vidova V, Kinsella MG, Chan CK, Johnson PY, Wight TN, Frevert CW. Reprint of: A rapid increase in macrophage-derived versican and hyaluronan in infectious lung disease. Matrix Biol. 2014 Apr;35:162-73. doi: 10.1016/j.matbio.2014.04.003. Epub 2014 Apr 12. PMID: 24727035

  4. Chen X, Bracht JR, Goldman AD, Dolzhenko E, Clay DM, Swart EC, Perlman DH, Doak TG, Stuart A, Amemiya CT, Sebra RP, Landweber LF. The architecture of a scrambled genome reveals massive levels of genomic rearrangement during development. Cell. 2014 Aug 28;158(5):1187-98. doi: 10.1016/j.cell.2014.07.034. PMID: 25171416

  5. Damodarasamy M, Johnson RS, Bentov I, MacCoss MJ, Vernon RB, Reed MJ. Hyaluronan enhances wound repair and increases collagen III in aged dermal wounds. Wound Repair Regen. 2014 Jul-Aug;22(4):521-6. doi: 10.1111/wrr.12192. PMID: 25041621

  6. Damodarasamy M, Vernon RB, Chan CK, Plymate SR, Wight TN, Reed MJ. Hyaluronan in aged collagen matrix increases prostate epithelial cell proliferation. In Vitro Cell Dev Biol Anim. 2014 Aug 15. PMID: 25124870

  7. Ghany MG, Perrillo R, Li R, Belle SH, Janssen HL, Terrault NA, Shuhart MC, Lau DT, Kim WR, Fried MW, Sterling RK, Di Bisceglie AM, Han SH, Ganova-Raeva LM, Chang KM, Lok AS; Hepatitis B Research Network [Kowdley KV]. Characteristics of Adults in the Hepatitis B Research Network in North America Reflect Their Country of Origin and Hepatitis B Virus Genotype. Clin Gastroenterol Hepatol. 2014 Jul 8. pii: S1542-3565(14)00976-8. doi: 10.1016/j.cgh.2014.06.028.  PMID: 25010003

  8. Iijima K, Kobayashi T, Hara K, Kephart GM, Ziegler SF, McKenzie AN, Kita H. IL-33 and thymic stromal lymphopoietin mediate immune pathology in response to chronic airborne allergen exposure. J Immunol. 2014 Aug 15;193(4):1549-59. doi: 10.4049/jimmunol.1302984. Epub 2014 Jul 11. PMID: 25015831

  9. Kawasaki K, Amemiya CT. SCPP Genes in the Coelacanth: Tissue mineralization genes shared by sarcopterygians. J Exp Zool B Mol Dev Evol. 2014 Sep;322(6):390-402. PMID: 25243252

  10. Kurmaeva E, Lord JD, Zhang S, Bao JR, Kevil CG, Grisham MB, Ostanin DV. T cell-associated α4β7 but not α4β1 integrin is required for the induction and perpetuation of chronic colitis. Mucosal Immunol. 2014 Apr 9. doi: 10.1038/mi.2014.22. PMID: 24717354 (Not Previously Reported)

  11. Lammers WJ, van Buuren HR, Hirschfield GM, Janssen HL, Invernizzi P, Mason AL, Ponsioen CY, Floreani A, Corpechot C, Mayo MJ, Battezzati PM, Parés A, Nevens F, Burroughs AK, Kowdley KV, Trivedi PJ, Kumagi T, Cheung A, Lleo A, Imam MH, Boonstra K, Cazzagon N, Franceschet I, Poupon R, Caballeria L, Pieri G, Kanwar PS, Lindor KD, Hansen BE; Global PBC Study Group. Levels of Alkaline Phosphatase and Bilirubin Are Surrogate End Points of Outcomes of Patients With Primary Biliary Cirrhosis: An International Follow-up Study. Gastroenterology. 2014 Aug 23. pii: S0016-5085(14)01040-3. doi: 10.1053/j.gastro.2014.08.029.  PMID: 25160979

  12. Linsley PS, Speake C, Whalen E, Chaussabel D. Copy number loss of the interferon gene cluster in melanomas is linked to reduced T cell infiltrate and poor patient prognosis. PLoS One. 2014 Oct 14;9(10):e109760. doi: 10.1371/journal.pone.0109760. eCollection 2014. PMID: 25314013

  13. McGinty JW, Chow IT, Greenbaum CJ, Odegard J, Kwok WW, James EA. Recognition of posttranslationally modified GAD65 epitopes in subjects with type 1 diabetes. Diabetes. 2014 Sep;63(9):3033-40. doi: 10.2337/db13-1952. Epub 2014 Apr 4. PMID: 24705406

  14. Muir AJ, Arora S, Everson G, Flisiak R, George J, Ghalib R, Gordon SC, Gray T, Greenbloom S, Hassanein T, Hillson J, Horga MA, Jacobson IM, Jeffers L, Kowdley KV, Lawitz E, Lueth S, Rodriguez-Torres M, Rustgi V, Shemanski L, Shiffman ML, Srinivasan S, Vargas HE, Vierling JM, Xu D, Lopez-Talavera JC, Zeuzem S; EMERGE study group. A randomized phase 2b study of peginterferon lambda-1a for the treatment of chronic HCV infection. J Hepatol. 2014 Jul 24. pii: S0168-8278(14)00521-2. doi: 10.1016/j.jhep.2014.07.022.  PMID: 25064437

  15. Muto T, Fukuoka A, Kabashima K, Ziegler SF, Nakanishi K, Matsushita K, Yoshimoto T. The role of basophils and proallergic cytokines, TSLP and IL-33, in cutaneously sensitized food allergy. Int Immunol. 2014 Oct;26(10):539-49. doi: 10.1093/intimm/dxu058. Epub 2014 May 22. PMID: 24860117

  16. Pugliese A, Vendrame F, Reijonen H, Atkinson MA, Campbell-Thompson M, Burke GW. New insight on human type 1 diabetes biology: nPOD and nPOD-transplantation. Curr Diab Rep. 2014 Oct;14(10):530. doi: 10.1007/s11892-014-0530-0. PMID: 25142715

  17. Renand A, Newbrough S, Wambre E, DeLong JH, Robinson D, Kwok WW. Arginine kinase Pen m 2 as an important shrimp allergen recognized by TH2 cells. J Allergy Clin Immunol. 2014 Sep 12. pii: S0091-6749(14)01052-5. doi: 10.1016/j.jaci.2014.07.048. PMID: 25224098

  18. Singh AK, Eken A, Fry M, Bettelli E, Oukka M. DOCK8 regulates protective immunity by controlling the function and survival of RORγt+ ILCs. Nat Commun. 2014 Aug 5;5:4603. doi: 10.1038/ncomms5603. PMID: 25091235

  19. Srivastava S, Koch LK, Campbell DJ. IFNαR Signaling in Effector but Not Regulatory T Cells Is Required for Immune Dysregulation during Type I IFN-Dependent Inflammatory Disease. J Immunol. 2014 Sep 15;193(6):2733-42. doi: 10.4049/jimmunol.1401039. Epub 2014 Aug 4. PMID: 25092894

  20. Yang J, Chow IT, Sosinowski T, Torres-Chinn N, Greenbaum CJ, James EA, Kappler JW, Davidson HW, Kwok WW. Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes. Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14840-5. doi: 10.1073/pnas.1416864111. Epub 2014 Sep 29. PMID: 25267644

From April - June 2014

  1. Afdhal N, Zeuzem S, Kwo P, Chojkier M, Gitlin N, Puoti M, Romero-Gomez M, Zarski JP, Agarwal K, Buggisch P, Foster GR, Bräu N, Buti M, Jacobson IM, Subramanian GM, Ding X, Mo H, Yang JC, Pang PS, Symonds WT, McHutchison JG, Muir AJ, Mangia A, Marcellin P; ION-1 Investigators [Kowdley KV]. Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection. N Engl J Med. 2014 May 15;370(20):1889-98. doi: 10.1056/NEJMoa1402454. Epub 2014 Apr 11. PMID: 24725239

  2. Afkarian M, Hirsch IB, Tuttle KR, Greenbaum C, Himmelfarb J, de Boer IH. Urinary excretion of RAS, BMP, and WNT pathway components in diabetic kidney disease. Physiol Rep, 2014 May 2:2(5):e12010. Doi: 10.14814/phy2.12010 PMID: 24793984

  3. Anderson ML, Nielsen LB, Svensson J, Pörksen S, Haugaard P, Beam C, Greenbaum C, Becker D, Petersen JS, Hansen L, Mortensen HB. Diabetes Progression among 446 children with newly diagnosed type 1 diabetes located in Scandinavia, Europe, and North American during the last 27 years. Pediatr Diabetes, 2013 Nov 25. Doi:10.1111/pedi.12098. PMID: 24731251

  4. Archila LD, DeLong JH, Wambre E, James EA, Robinson DM, Kwok WW. Grass-specific CD4+ T-cells exhibit varying degrees of cross-reactivity, implications for allergen-specific immunotherapy. Clin Exp Allergy. 2014 Apr 8. doi: 10.1111/cea.12324. [Epub ahead of print] PMID: 24708411

  5. Blankley S, Graham CM, Howes A, Bloom CI, Berry MP, Chaussabel D, Pascual V, Banchereau J, Lipman M, O'Garra A. Identification of the key differential transcriptional responses of human whole blood following TLR2 or TLR4 ligation in-vitro. PLoS One. 2014 May 19;9(5):e97702. doi: 10.1371/journal.pone.0097702. eCollection 2014. PMID: 24842522

  6. Bogdani M, Johnson PY, Potter-Perigo S, Nagy N, Day AJ, Bollyky PL, Wight TN. Hyaluronan and Hyaluronan Binding Proteins Accumulate in both Human Type 1 Diabetic Islets and Lymphoid Tissues and Associate with Inflammatory Cells in Insulitis. Diabetes. 2014 Mar 27. [Epub ahead of print] PMID: 24677718

  7. Chaussabel D, Baldwin N. Democratizing systems immunology with modular transcriptional repertoire analyses. Nat Rev Immunol. 2014 Apr;14(4):271-80. doi: 10.1038/nri3642. PMID: 24662387

  8. Chen YG, Cabrera SM, Jia S, Kaldunski ML, Kramer J, Cheong S, Geoffrey R, Roethle MF, Woodliff JE, Greenbaum CJ, Wang X, Hessner MJ. Molecular signatures differentiate immune states in Type 1 Diabetes families. Diabetes, 2014 April 23 [Epub ahead of print] PMID: 24760139

  9. Chiche L, Jourde-Chiche N, Whalen E, Presnell S, Gersuk V, Dang K, Anguiano E, Quinn C, Burtey S, Berland Y, Kaplanski G, Harle JR, Pascual V, Chaussabel D. Modular Transcriptional Repertoire Analyses of Adults With Systemic Lupus Erythematosus Reveal Distinct Type I and Type II Interferon Signatures. Arthritis Rheumatol. 2014 Jun;66(6):1583-95. doi: 10.1002/art.38628. PMID: 24644022

  10. Duhen T, Campbell DJ. IL-1β Promotes the Differentiation of Polyfunctional Human CCR6+CXCR3+ Th1/17 Cells That Are Specific for Pathogenic and Commensal Microbes. J Immunol. 2014 Jul 1;193(1):120-9. doi: 10.4049/jimmunol.1302734. Epub 2014 Jun 2. PMID: 24890729

  11. Durinovic-Belló I, Gersuk VH, Ni C, Wu R, Thorpe J, Jospe N, Sanda S, Greenbaum CJ, Nepom GT. Avidity-Dependent Programming of Autoreactive T Cells in T1D. PLoS One, 2014 May 20;9(5):e98074 doi: 10.1371/journal.pone.0098074. eCollection 2014. PMID: 24844227

  12. Feld JJ, Kowdley KV, Coakley E, Sigal S, Nelson DR, Crawford D, Weiland O, Aguilar H, Xiong J, Pilot-Matias T, DaSilva-Tillmann B, Larsen L, Podsadecki T, Bernstein B. Treatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirin. N Engl J Med. 2014 Apr 24;370(17):1594-603. doi: 10.1056/NEJMoa1315722. Epub 2014 Apr 10. PMID: 24720703

  13. Hauri-Hohl M, Zuklys S, Holländer GA, Ziegler SF. A regulatory role for TGF-β signaling in the establishment and function of the thymic medulla. Nat Immunol. 2014 Jun;15(6):554-61. doi: 10.1038/ni.2869. Epub 2014 Apr 13. PMID: 24728352

  14. James EA, Rieck M, Pieper J, Gebe JA, Yue BB, Tatum M, Peda M, Sandin C, Klareskog L, Malmström V, Buckner JH. Citrulline-specific Th1 cells are increased in rheumatoid arthritis and their frequency is influenced by disease duration and therapy. Arthritis Rheumatol. 2014 Jul;66(7):1712-22. doi: 10.1002/art.38637. PMID: 24665079

  15. Kaneko K, Ito M, Naoe Y, Lacy-Hulbert A, Ikeda K. Integrin αv in the mechanical response of osteoblast lineage cells. Biochem Biophys Res Commun. 2014 May 2;447(2):352-7. doi: 10.1016/j.bbrc.2014.04.006. Epub 2014 Apr 13. PMID: 24726648

  16. Kang I, Yoon DW, Braun KR, Wight TN. Expression of Versican V3 by Arterial Smooth Muscle Cells Alters Tumor Growth Factor β (TGFβ)-, Epidermal Growth Factor (EGF)-, and Nuclear Factor κB (NFκB)-dependent Signaling Pathways, Creating a Microenvironment That Resists Monocyte Adhesion. J Biol Chem. 2014 May 30;289(22):15393-15404. Epub 2014 Apr 9. PMID: 24719328

  17. Kowdley KV, Gordon SC, Reddy KR, Rossaro L, Bernstein DE, Lawitz E, Shiffman ML, Schiff E, Ghalib R, Ryan M, Rustgi V, Chojkier M, Herring R, Di Bisceglie AM, Pockros PJ, Subramanian GM, An D, Svarovskaia E, Hyland RH, Pang PS, Symonds WT, McHutchison JG, Muir AJ, Pound D, Fried MW; ION-3 Investigators. Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosis. N Engl J Med. 2014 May 15;370(20):1879-88. doi: 10.1056/NEJMoa1402355. Epub 2014 Apr 10. PMID: 24720702

  18. Kowdley KV. Advances in the diagnosis and treatment of nonalcoholic steatohepatitis. Gastroenterol Hepatol (N Y). 2014 Mar;10(3):184-6. PMID: 24829546

  19. Kratz M, Marcovina S, Nelson JE, Yeh MM, Kowdley KV, Callahan HS, Song X, Di C, Utzschneider KM. Dairy fat intake is associated with glucose tolerance, hepatic and systemic insulin sensitivity, and liver fat but not β-cell function in humans. Am J Clin Nutr. 2014 Apr 16;99(6):1385-1396. [Epub ahead of print]. PMID: 24740208

  20. Lammers WJ, Kowdley KV, van Buuren HR. Predicting outcome in primary biliary cirrhosis. Ann Hepatol. 2014 Jul-Aug;13(4):316-26. PMID: 24927602

  21. Luo J, Weaver MS, Cao B, Dennis JE, Van Biber B, Laflamme MA, Allen MD. Cobalt protoporphyrin pretreatment protects human embryonic stem cell-derived cardiomyocytes from hypoxia/reoxygenation injury in vitro and increases graft size and vascularization in vivo. Stem Cells Transl Med. 2014 Jun;3(6):734-44. doi: 10.5966/sctm.2013-0189. Epub 2014 Apr 15. PMID: 24736402

  22. McGinty JW, Chow IT, Greenbaum C, Odegard J, Kwok WW, James EA. Recognition of post-translationally modified glutamic acid decarboxylase 65 epitopes in subjects with type 1 diabetes. Diabetes, 2014 April 4 [Epub ahead of print]. PMID: 24705406

  23. Merrilees MJ, Falk BA, Zuo N, Dickinson ME, May BC, Wight TN. Use of versican variant V3 and versican antisense expression to engineer cultured human skin containing increased content of insoluble elastin. J Tissue Eng Regen Med. 2014 Jun 19. doi: 10.1002/term.1913. [Epub ahead of print] PMID: 24945362

  24. Nemeth CL, Janebodin K, Yuan AE, Dennis JE, Reyes M, Kim DH. Enhanced Chondrogenic Differentiation of Dental Pulp Stem Cells Using Nanopatterned PEG-GelMA-HA Hydrogels. Tissue Eng Part A. 2014 Jun 30. [Epub ahead of print] PMID: 24749806

  25. Poordad F, Hezode C, Trinh R, Kowdley KV, Zeuzem S, Agarwal K, Shiffman ML, Wedemeyer H, Berg T, Yoshida EM, Forns X, Lovell SS, Da Silva-Tillmann B, Collins CA, Campbell AL, Podsadecki T, Bernstein B. ABT-450/r-ombitasvir and dasabuvir with ribavirin for hepatitis C with cirrhosis. N Engl J Med. 2014 May 22;370(21):1973-82. doi: 10.1056/NEJMoa1402869. Epub 2014 Apr 11. PMID: 24725237

  26. Ramsdell F, Ziegler SF. FOXP3 and scurfy: how it all began. Nat Rev Immunol. 2014 May;14(5):343-9. doi: 10.1038/nri3650. Epub 2014 Apr 11. PMID: 24722479

  27. Reeves SR, Kolstad T, Lien TY, Elliott M, Ziegler SF, Wight TN, Debley JS. Asthmatic airway epithelial cells differentially regulate fibroblast expression of extracellular matrix components. J Allergy Clin Immunol. 2014 May 26. pii: S0091-6749(14)00568-5. doi: 10.1016/j.jaci.2014.04.007. [Epub ahead of print] PMID: 24875618

  28. Smigiel KS, Srivastava S, Stolley JM, Campbell DJ. Regulatory T-cell homeostasis: steady-state maintenance and modulation during inflammation. Immunol Rev. 2014 May;259(1):40-59. doi: 10.1111/imr.12170. PMID: 24712458

  29. Smilek DE, Ehlers MR, Nepom GT. Restoring the balance: immunotherapeutic combinations for autoimmune disease. Dis Model Mech. 2014 May;7(5):503-13. doi: 10.1242/dmm.015099. PMID: 24795433

  30. Srivastava S, Koch MA, Pepper M, Campbell DJ. Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection. J Exp Med. 2014 May 5;211(5):961-74. doi: 10.1084/jem.20131556. Epub 2014 Apr 7. PMID: 24711580

  31. Tam JM, Mansour MK, Khan NS, Seward M, Puranam S, Tanne A, Sokolovska A, Becker CE, Acharya M, Baird MA, Choi AM, Davidson MW, Segal BH, Lacy-Hulbert A, Stuart LM, Xavier RJ, Vyas JM. Dectin-1-Dependent LC3 Recruitment to Phagosomes Enhances Fungicidal Activity in Macrophages. J Infect Dis. 2014 May 19. pii: jiu290. [Epub ahead of print] PMID: 24842831

  32. Tsang JS, Schwartzberg PL, Kotliarov Y, Biancotto A, Xie Z, Germain RN, Wang E, Olnes MJ, Narayanan M, Golding H, Moir S, Dickler HB, Perl S, Cheung F; Baylor HIPC Center; CHI Consortium [Chaussabel D]. Global analyses of human immune variation reveal baseline predictors of postvaccination responses. Cell. 2014 Apr 10;157(2):499-513. doi: 10.1016/j.cell.2014.03.031. PMID: 24725414

  33. VanBuecken DE, Greenbaum CJ. Residual C-peptide in type 1 diabetes: what do we really know? Pediatr Diabetes, 2014 Mar;15(2):84-90. Doi:10.1111/pedi.12135. PMID: 24645775

From January - March 2014

  1. Amemiya CT. An Ancient Mariner. The Biochemist (Molecular Evolution), Feb;36:23-27.

  2. Chang MY, Tanino Y, Vidova V, Kinsella MG, Chan CK, Johnson PY, Wight TN, Frevert CW. A rapid increase in macrophage-derived versican and hyaluronan in infectious lung disease. Matrix Biol. 2014 Jan 26. pii: S0945-053X(14)00022-5. doi: 10.1016/j.matbio.2014.01.011. PMID: 24472738

  3. Gupta S, Cerosaletti K, Long SA. Renegade homeostatic cytokine responses in T1D: Drivers of regulatory/effector T cell imbalance. Clin Immunol. 2014 Feb 24;151(2):146-154. doi: 10.1016/j.clim.2014.02.007. PMID: 24576418

  4. Handa P, Kowdley KV. Chemokines: potent mediators of hepatic inflammation and fibrosis in chronic liver diseases. Ann Hepatol. 2013 Jan-2014 Feb;13(1):152-4. PMID: 24378280

  5. Khaenam P, Rinchai D, Altman MC, Chiche L, Buddhisa S, Kewcharoenwong C, Suwannasaen D, Mason M, Whalen E, Presnell S, Susaengrat W, O'Brien K, Nguyen QA, Gersuk V, Linsley PS, Lertmemongkolchai G, Chaussabel D. A transcriptomic reporter assay employing neutrophils to measure immunogenic activity of septic patients' plasma. J Transl Med. 2014 Mar 11;12(1):65. doi: 10.1186/1479-5876-12-65. PMID: 24612859

  6. Kowdley KV, Lawitz E, Poordad F, Cohen DE, Nelson DR, Zeuzem S, Everson GT, Kwo P, Foster GR, Sulkowski MS, Xie W, Pilot-Matias T, Liossis G, Larsen L, Khatri A, Podsadecki T, Bernstein B. Phase 2b trial of interferon-free therapy for hepatitis C virus genotype 1. N Engl J Med. 2014 Jan 16;370(3):222-32. doi: 10.1056/NEJMoa1306227. PMID: 24428468

  7. Larson S, Ramsey C, Tinnemore D, Amemiya CT. 2014. Novel Loci Variation and Population Genetics within Leafy Seadragons, Phycodurus eques. Diversity 2014, 6, 33-42; doi:10.3390/d6010033. ISSN 1424-2818

  8. Li S, Rouphael N, Duraisingham S, Romero-Steiner S, Presnell S, Davis C, Schmidt DS, Johnson SE, Milton A, Rajam G, Kasturi S, Carlone GM, Quinn C, Chaussabel D, Palucka AK, Mulligan MJ, Ahmed R, Stephens DS, Nakaya HI, Pulendran B. Molecular signatures of antibody responses derived from a systems biology study of five human vaccines. Nat Immunol. 2014 Feb;15(2):195-204. doi: 10.1038/ni.2789. PMID: 24336226

  9. Mason MJ, Speake C, Gersuk VH, Nguyen QA, O'Brien KK, Odegard JM, Buckner JH, Greenbaum CJ, Chaussabel D, Nepom GT. Low HERV-K(C4) Copy Number is Associated with Type 1 Diabetes. Diabetes. 2014 Jan 15. PMID: 24430436

  10. Robinson M, Amemiya CT. Coelacanths. Curr Biol. 2014 Jan 20;24(2):R62-3. doi: 10.1016/j.cub.2013.10.027. PMID: 24456974

  11. Ruppert SM, Hawn TR, Arrigoni A, Wight TN, Bollyky PL. Tissue integrity signals communicated by high-molecular weight hyaluronan and the resolution of inflammation. Immunol Res. 2014 Mar 11. PMID: 24614953

  12. Saha NR, Ota T, Litman GW, Hansen J, Parra Z, Hsu E, Buonocore F, Canapa A, Cheng JF, Amemiya CT. Genome complexity in the coelacanth is reflected in its adaptive immune system. J Exp Zool B Mol Dev Evol. 2014 Jan 24. doi: 10.1002/jez.b.22558. PMID: 24464682

  13. Savar A, Acin S, Gonzalez CL, El-Sawy T, Mejia O, Li Z, Esmaeli B, Lacy-Hulbert A, El-Naggar AK, McCarty JH, Caulin C. Loss of epithelial p53 and αv integrin cooperate through Akt to induce squamous cell carcinoma yet prevent remodeling of the tumor microenvironment. Oncogene. 2014 Jan 27. doi: 10.1038/onc.2013.585. PMID: 24469034

  14. Sivendran S, Chang R, Pham L, Phelps R, Harcharik S, Hall L, Bernardo S, Moskalenko M, Sivendran M, Fu Y, de Moll EH, Pan M, Moon JY, Arora S, Cohain A, Difeo A, Ferringer T, Tismenetsky M, Tsui C, Friedlander P, Parides M, Banchereau J, Chaussabel D, Lebwohl M, Wolchok J, Bhardwaj N, Burakoff S, Oh W, Palucka K, Merad M, Schadt E, Saenger Y. Dissection of Immune Gene Networks in Primary Melanoma Tumors Critical for Anti-Tumor Surveillance of Patients with Stage II-III Resectable Disease. J Invest Dermatol. 2014 Feb 12. doi: 10.1038/jid.2014.85. PMID: 24522433

  15. Sosenko JM, Skyler JS, Mahon J, Krischer JP, Greenbaum CJ, Rafkin LE, Beam CA, Boulware DC, Matheson D, Cuthbertson D, Herold KC, Eisenbarth G, Palmer JP; the Type 1 Diabetes TrialNet and Diabetes Prevention Trial-Type 1 study Groups. Use of the Diabetes Prevention Trial-Type 1 Risk Score (DPTRS) for Improving the Accuracy of the Risk Classification of Type 1 Diabetes. Diabetes Care. 2014 Apr;37(4):979-84. doi: 10.2337/dc13-2359. Epub 2014 Feb 18. PMID: 24550217

  16. Wight TN, Kang I, Merrilees MJ. Versican and the control of inflammation. Matrix Biol. 2014 Feb 7. pii: S0945-053X(14)00036-5. doi: 10.1016/j.matbio.2014.01.015. PMID: 24513039

  17. Wight TN, Kinsella MG, Evanko SP, Potter-Perigo S, Merrilees MJ. Versican and the regulation of cell phenotype in disease. Biochim Biophys Acta. 2014 Jan 5. pii: S0304-4165(13)00557-6. doi: 10.1016/j.bbagen.2013.12.028. PMID: 24401530

From October - December 2013

  1. Bambha K, Wilson LA, Unalp A, Loomba R, Neuschwander-Tetri BA, Brunt EM, Bass NM; NASH CRN [Kowdley KV, Nelson JE]. Coffee consumption in NAFLD patients with lower insulin resistance is associated with lower risk of severe fibrosis. Liver Int. 2013 Nov 5. doi: 10.1111/liv.12379. PMID: 24267865

  2. Buckingham B, Beck RW, Ruedy KJ, Cheng P, Kollman C, Weinzimer SA, DiMeglio LA, Bremer AA, Slover R, Tamborlane WV; Diabetes Research in Children Network (DirecNet) Study Group; Type 1 Diabetes TrialNet Study Group [Buckner JH]. Effectiveness of early intensive therapy on β-cell preservation in type 1 diabetes. Diabetes Care. 2013 Dec;36(12):4030-5. doi: 10.2337/dc13-1074. Epub 2013 Oct 15. PMID: 24130350

  3. Cerosaletti K, Schneider A, Schwedhelm K, Frank I, Tatum M, Wei S, Whalen E, Greenbaum C, Kita M, Buckner J, Long SA. Multiple Autoimmune-Associated Variants Confer Decreased IL-2R Signaling in DC4(+)CD25(hi) T Cells of Type 1 Diabetic and Multiple Sclerosis Patients. PLoS One. 2013 Dec 23;8(12):e83811. doi: 10.1371/journal.pone.0083811. eCollection 2013. PMID: 24376757 |  PMC3871703

  4. Dahan R, Gebe JA, Preisinger A, James EA, Tendler M, Nepom GT, Reiter Y. Antigen-specific immunomodulation for type 1 diabetes by novel recombinant antibodies directed against diabetes-associates auto-reactive T cell epitope. J Autoimmun. 2013 Dec;47:83-93. doi: 10.1016/j.jaut.2013.08.009. Epub 2013 Oct 3. PMID: 24090977

  5. Dennis JE, Lord JD. (2013) Mesenchymal stem cells for the treatment of inflammatory bowel disease, In: Gross, Gerhard / Häupl, Thomas (Eds.) Stem Cell-Dependent Therapies: Mesenchymal Stem Cells in Chronic Inflammatory Disorders (pp. 211-224). DeGruyter; Berlin, Germany.

  6. Estorninho M, Gibson VB, Kronenberg-Versteeg D, Liu YF, Ni C, Cerosaletti K, Peakman M. A novel approach to tracking antigen-experienced CD4 T cells into functional compartments via tandem deep and shallow TCR clonotyping. J Immunol. 2013 Dec 1;191(11):5430-40. doi: 10.4049/jimmunol.1300622. Epub 2013 Oct 25. PMID: 24163407

  7. Handa P, Maliken BD, Nelson JE, Morgan-Stevenson V, Messner DJ, Dhillon BK, Klintworth HM, Beauchamp M, Yeh MM, Elfers CT, Roth CL, Kowdley KV. Reduced adiponectin signaling due to weight gain results in nonalcoholic steatohepatitis through impaired mitochondrial biogenesis. Hepatology. 2013 Nov 21. doi: 10.1002/hep.26946. PMID: 24464605

  8. Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH, Sheppard D. Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med. 2013 Dec;19(12):1617-24. doi: 10.1038/nm.3282. Epub 2013 Nov 10. PMID: 24216753

  9. James EA, LaFond RE, Gates TJ, Mai DT, Malhotra U, Kwok WW. Yellow fever vaccination elicits broad functional CD4+ T cell responses that recognize structural and nonstructural proteins. J Virol. 2013 Dec;87(23):12794-804. doi: 10.1128/JVI.01160-13. Epub 2013 Sep 18. PMID: 24049183

  10. Kailaanmäki A, Kinnunen T, Kwok WW, Rytkönen-Nissinen M, Randell J, Virtanen T. Differential CD4(+) T-cell responses of allergic and non-allergic subjects to the immunodominant epitope region of the horse major allergen Equ c 1. Immunology. 2014 Jan;141(1):52-60. doi: 10.1111/imm.12166. PMID: 23991693

  11. Kanwar P, Kowdley KV. Metal storage disorders: Wilson disease and hemochromatosis. Med Clin North Am. 2014 Jan;98(1):87-102. doi: 10.1016/j.mcna.2013.09.008. Epub 2013 Oct 28. PMID: 24266916

  12. Kowdley KV, Burman BE. ACP Journal Club. Adding rifaximin to lactulose increased reversal and decreased mortality in hepatic encephalopathy. Ann Intern Med. 2013 Oct 15;159(8):JC8. doi: 10.7326/0003-4819-159-8-201310150-02008. PMID: 24126669

  13. Mejias A, Dimo B, Suarez NM, Garcia C, Suarez-Arrabal MC, Jartti T, Blankenship D, Jordan-Villegas A, Ardura MI, Xu Z, Banchereau J, Chaussabel D, Ramilo O. Whole blood gene expression profiles to assess pathogenesis and disease severity in infants with respiratory syncytial virus infection. PLoS Med. 2013 Nov;10(11):e1001549. doi: 10.1371/journal.pmed.1001549. Epub 2013 Nov 12. PMID: 24265599

  14. Nitsche A, Doose G, Tafer H, Robinson M, Saha NR, Gerdol M, Canapa A, Hoffmann S, Amemiya CT, Stadler PF. Atypical RNAs in the coelacanth transcriptome. J Exp Zool B Mol Dev Evol. 2013 Oct 30. doi: 10.1002/jez.b.22542. [Epub ahead of print] PMID: 24174405

  15. Noureddin M, Yates KP, Vaughn IA, Neuschwander-Tetri BA, Sanyal AJ, McCullough A, Merriman R, Hameed B, Doo E, Kleiner DE, Behling C, Loomba R; NASH CRN [Kowdley KV, Nelson JE]. Clinical and histological determinants of nonalcoholic steatohepatitis and advanced fibrosis in elderly patients. Hepatology. 2013 Nov;58(5):1644-54. doi: 10.1002/hep.26465. PMID: 23686698 | PMC3760979

  16. Obika M, Vernon RB, Gooden MD, Braun KR, Chan CK, Wight TN. ADAMTS-4 and Biglycan are Expressed at High Levels and Co-Localize to Podosomes During Endothelial Cell Tubulogenesis In Vitro. J Histochem Cytochem. 2014 Jan;62(1):34-49. doi: 10.1369/0022155413507727. Epub 2013 Sep 18. PMID: 24051360

  17. Orban T, Bundy B, Becker DJ, Dimeglio LA, Gitelman SE, Goland R, Gottlieb PA, Greenbaum CJ, Marks JP, Monzavi R, Moran A, Peakman M, Raskin P, Russell WE, Schatz D, Wherrett DK, Wilson MD, Krischer JP, Skyler JS; the Type 1 Diabetes TrialNet Abatacept Study Group.  Co-Stimulation Modulation with Abatacept in Patients with Recent-Onset Type 1 Diabetes: Follow-up One Year After Cessation of Treatment. Diabetes Care, 2013 Dec 2 PMID: 24296850

  18. Park J, Munagala I, Xu H, Blankenship D, Maffucci P, Chaussabel D, Banchereau J, Pascual V, Cunningham-Rundles C. Interferon signature in the blood in inflammatory common variable immune deficiency. PLoS One. 2013 Sep 17;8(9):e74893. doi: 10.1371/journal.pone.0074893. PMID: 24069364

  19. Pieper J, Johansson S, Snir O, Linton L, Rieck M, Buckner JH, Winqvist O, van Vollenhoven R, Malmström V. Peripheral and site-specific CD4(+) CD28(null) T cells from rheumatoid arthritis patients show distinct characteristics. Scand J Immunol. 2014 Feb;79(2):149-55. doi: 10.1111/sji.12139. PMID: 24313359

  20. Rigby MR, Dimeglio LA, Rendell MS, Felner EI, Dostou JM, Gitelman SE, Patel CM, Griffin KJ, Tsalikian E, Gottlieb PA, Greenbaum CJ, Sherry NA, Moore WV, Monzavi R, Willi SM, Raskin P, Moran A, Russell WE, Pinckney A, Keyes-Elstein L, Howell M, Aggarwal S, Lim N, Phippard D, Nepom GT, McNamara J, Ehlers MR; T1DAL Study Team. Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL Study): 12 month results of a randomized, double-blind, placebo-controlled phase 2 trial. Lancet Diabetes Endocrinol. 2013 Dec;1(4):284-94. doi: 10.1016/S2213-8587(13)70111-6. Epub 2013 Sep 23. PMID: 24622414

  21. Shah N, Nelson JE, Kowdley KV. MicroRNAs in Liver Disease: Bench to Bedside. J Clin Exp Hepatol. 2013 Sep;3(3):231-42.

  22. Siddique A, Nelson JE, Aouizerat B, Yeh MM, Kowdley KV; NASH Clinical Research Network. Iron Deficiency in Patients with Nonalcoholic Fatty Liver Disease Is Associated with Obesity, Female Gender, and Low Serum Hepcidin. Clin Gastroenterol Hepatol. 2013 Nov 20. pii: S1542-3565(13)01784-9. doi: 10.1016/j.cgh.2013.11.017. [Epub ahead of print] PMID: 24269922

  23. Till SJ, Raynsford EJ, Reynolds CJ, Quigley KJ, Grzybowska-Kowalczyk A, Saggar LR, Goldstone A, Maillere B, Kwok WW, Altmann DM, Durham SR, Boyton RJ. Peptide-induced immune regulation by a promiscuous and immunodominant CD4T-cell epitope of Timothy grass pollen: a role of Cbl-b and Itch in regulation. Thorax. 2013 Nov 20. doi: 10.1136/thoraxjnl-2013-204324. (not previously reported) PMID: 24258832

  24. Utzschneider KM, Largajolli A, Bertoldo A, Marcovina S, Nelson JE, Yeh MM, Kowdley KV, Kahn SE. Serum ferritin is associated with non-alcoholic fatty liver disease and decreased Β-cell function in non-diabetic men and women. J Diabetes Complications. 2013 Nov 26. pii: S1056-8727(13)00285-7. doi: 10.1016/j.jdiacomp.2013.11.007. [Epub ahead of print] PMID: 24360972

  25. Wambre E, DeLong JH, James EA, Torres-Chinn N, Pfützner W, Möbs C, Durham SR, Till SJ, Robinson D, Kwok WW. Specific immunotherapy modifies allergen-specific CD4(+) T-cell responses in an epitope-dependent manner. J Allergy Clin Immunol. 2014 Mar;133(3):872-879.e7. doi: 10.1016/j.jaci.2013.10.054. Epub 2013 Dec 25. PMID: 24373351 | PMC3961577

  26. Wen J, Cerosaletti K, Schultz KJ, Wright JA, Concannon P. NBN phosphorylation regulates the accumulation of MRN and ATM at sites of DNA double-strand breaks. Oncogene. 2013 Sep 12;32(37):4448-56. doi: 10.1038/onc.2012.443. Epub 2012 Nov 12. PMID: 23146902

  27. Zaidi MB, Estrada-García T, Campos FD, Chim R, Arjona F, Leon M, Michell A, Chaussabel D. Incidence, clinical presentation, and antimicrobial resistance trends in Salmonella and Shigella infections from children in Yucatan, Mexico. Front Microbiol. 2013 Oct 1;4:288. doi: 10.3389/fmicb.2013.00288. PMID: 24098297


From July - September 2013

  1. Ahmed ST, Akirav E, Bradshaw E, Buckner J, McKinney E, Quintana FJ, Waldron-Lynch F, Nepom J. Immunological biomarkers: catalysts for translational advances in autoimmune diabetes. Clin Exp Immunol. 2013 May;172(2):178-85. doi: 10.1111/cei.12063. PMID: 23574315

  2. Bloom CI, Graham CM, Berry MP, Rozakeas F, Redford PS, Wang Y, Xu Z, Wilkinson KA, Wilkinson RJ, Kendrick Y, Devouassoux G, Ferry T, Miyara M, Bouvry D, Dominique V, Gorochov G, Blankenship D, Saadatian M, Vanhems P, Beynon H, Vancheeswaran R, Wickremasinghe M, Chaussabel D, Banchereau J, Pascual V, Ho LP, Lipman M, O'Garra A. Transcriptional blood signatures distinguish pulmonary tuberculosis, pulmonary sarcoidosis, pneumonias and lung cancers. PLoS One. 2013 Aug 5;8(8):e70630. doi: 10.1371/journal.pone.0070630. Print 2013. PMID: 23940611

  3. Bollyky JB, Long SA, Fitch M, Bollyky PL, Rieck M, Rogers R, Samuels PL, Sanda S, Buckner JH, Hellerstein MK, Greenbaum CJ. Evaluation of in vivo T cell kinetics: use of heavy isotope labelling in type 1 diabetes. Clin Exp Immunol. 2013 June. PMID: 23600824

  4. Bollyky PL, Vernon RB, Falk BA, Preisinger A, Gooden MD, Nepom GT, Gebe JA. IL-10 induction from implants delivering pancreatic islets and hyaluronan. J Diabetes Res. 2013;2013:342479. doi: 10.1155/2013/342479. Epub 2013 Jul 22. PMID: 23971054

  5. Crume TL, Andrews JS, D'Agostino RB, Pettitt DJ, Mayer-Davis EJ, Law JR, Dolan L, Lawrence JM, Saydah S, Greenbaum C, Rodriguez BL, Dabelea D. The Influence of exposure to maternal diabetes in utero on the rate of decline in beta-cell function among youth with diabetes. J Pediatr Endocrinol Metab, 2013 PMID: 23645121

  6. Gilliam LK, Pihoker C, Ellard S, Hattersley AT, Dabelea D, Davis C, Dolan LM, Greenbaum CJ, Imperatore G, Lawrence JM, Marcovina SM, Mayer-Davis E, Rodriguez BL, Steck AK, Williams DE; for the SEARCH for Diabetes In Youth Study Group. Prevalence, Characteristics and Clinical Diagnosis of Maturity Onset Diabetes in Youth Due to Mutation sin HNF1A, HNF4A, and Glucokinase: Results from the SEARCH for Diabetes in Youth. J Clin Endocrinol Metab, 2013 June 14. PMID: 23771925

  7. Herold KC, Gitelman SE, Ehlers MR, Gottlieb PA, Greenbaum CJ, Hagopian W, Boyle KD, Keys-Elstein L, Aggarwal S, Phippard D, Sayre PH, McNamara J, Bluestone JA,; the AbATE Study Team. Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a ramdomized controlled trial: Metabolic and immunologic features at baseline identify a subgroup of responders. Diabetes, 2013 July 8. PMID: 23835333

  8. Kanwar P, Kowdley KV. Diagnosis and treatment of hereditary hemochromatosis: an update. Expert Rev Gastroenterol Hepatol. 2013 Aug;7(6):517-30. doi: 10.1586/17474124.2013.816114. PMID: 23985001

  9. Kean TJ, Lin P, Caplan AI, Dennis JE. MSCs: Delivery Routes and Engraftment, Cell-Targeting Strategies, and Immune Modulation. Stem Cells Int. 2013;2013:732742. doi: 10.1155/2013/732742. Epub 2013 Aug 13. PMID: 24000286

  10. Kuhn LT, Liu Y, Boyd NL, Dennis J, Jiang X, Xin X, Charles L, Wang L, Aguila HL, Rowe D, Lichtler A, Goldberg AJ. Developmental-like Bone Regeneration By Human Embryonic Stem Cell-derived Mesenchymal Cells. Tissue Eng Part A. 2013 Aug 17. [Epub ahead of print] PMID: 23952622

  11. Lin P, Correa D, Kean TJ, Awadallah A, Dennis JE, Caplan AI. Serial Transplantation and Long-Term Engraftment of Intraarterially Delivered Clonally-Derived Mesenchymal Stem Cells to Injured Bone Marrow. Mol Ther. 2013 Sep 25. doi: 10.1038/mt.2013.221. [Epub ahead of print] PMID: 24067545

  12. Mauseth R, Hirsch IR, Bollyky J, Kircher R, Matheson D, Sanda S, Greenbaum C. Use of a "fuzzy logic" controller in a closed-loop artificial pancreas. Diabetes Technol ther, 2013 Aug 15(8). PMID: 23829285

  13. McNab FW, Ewbank J, Rajsbaum R, Stavropoulos E, Martirosyan A, Redford PS, Wu X, Graham CM, Saraiva M, Tsichlis P, Chaussabel D, Ley SC, O'Garra A. TPL-2-ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I IFN production. J Immunol. 2013 Aug 15;191(4):1732-43. doi: 10.4049/jimmunol.1300146. Epub 2013 Jul 10. PMID: 23842752

  14. Moran A, Bundy B, Becker DJ, DiMeglio LA, Gitelman SE, Goland R, Greenbaum CJ, Herold KC, Marks JB, Raskin P, Sanda S, Schatz D, Wherrett DK, Wilson DM, Krischer JP, Skyler JS; Type 1 Diabetes TrialNet Canakinumab Study Group, Pickersgill L, de Koning E, Ziegler AG, Böehm B, Badenhoop K, Schloot N, Bak JF, Pozzilli P, Mauricio D, Donath MY, Castano L, Wagner A, Lervang HH, Perrid H, Mandrup-Pouslen T; AIDA Study Group, Pociot F, Dinarello CA. Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicenter, randomized, double-blind, placebo-controlled trials. Lancet 2013 Jun 1. PMID: 23562090

  15. Nepom GT, Ehlers M, Mandrup-Poulsen T. Anti-cytokine therapies in T1D: Concepts and strategies. Clin Immunol. 2013 Feb 14. pii: S1521-6616(13)00029-6. doi: 10.1016/j.clim.2013.02.003. [Epub ahead of print] PMID: 23510726

  16. Pescovitz MD, Greenbaum CJ, Bundy B, Beker DJ, Gitelman SE, Goland R, Gottlieb PA, Marks JB, Moran A, Raskin P, Rodriguez H, Schatz DA, Wherrett DK, Wilson DM, Krischer JP, Skyler JS; and the Type 1 Diabetes TrialNet Anti-CD20 Study Group. B-Lymphocyte Depletion with Rituximab and Beta-Cell Function: Two-Year Results. Diabetes Care, 2013, Sep 11. PMID: 24026563

  17. Sosenko JM, Skyler JS, Beam CA, Krischer JP, Greenbaum CJ, Mahon J, Rafkin LE, Matheson D, Herold KC, Palmer JP; The Diabetes Type 1 TrialNet and Diabetes Prevention Trial-Type 1 Study Groups. The Acceleration of the Loss of the First-Phase Insulin Response during the Progression to Type 1 Diabetes in Diabetes Prevention Trial-Type 1 Participants. Diabetes, 2013 July 17. PMID: 23863814

From March - June 2013

  1. Amemiya CT, Alföldi J, Lee AP, Fan S, Philippe H, Maccallum I, Braasch I, Manousaki T, Schneider I, Rohner N, Organ C, Chalopin D, Smith JJ, Robinson M, Dorrington RA, Gerdol M, Aken B, Biscotti MA, Barucca M, Baurain D, Berlin AM, Blatch GL, Buonocore F, Burmester T, Campbell MS, Canapa A, Cannon JP, Christoffels A, De Moro G, Edkins AL, Fan L, Fausto AM, Feiner N, Forconi M, Gamieldien J, Gnerre S, Gnirke A, Goldstone JV, Haerty W, Hahn ME, Hesse U, Hoffmann S, Johnson J, Karchner SI, Kuraku S, Lara M, Levin JZ, Litman GW, Mauceli E, Miyake T, Mueller MG, Nelson DR, Nitsche A, Olmo E, Ota T, Pallavicini A, Panji S, Picone B, Ponting CP, Prohaska SJ, Przybylski D, Saha NR, Ravi V, Ribeiro FJ, Sauka-Spengler T, Scapigliati G, Searle SM, Sharpe T, Simakov O, Stadler PF, Stegeman JJ, Sumiyama K, Tabbaa D, Tafer H, Turner-Maier J, van Heusden P, White S, Williams L, Yandell M, Brinkmann H, Volff JN, Tabin CJ, Shubin N, Schartl M, Jaffe DB, Postlethwait JH, Venkatesh B, Di Palma F, Lander ES, Meyer A, Lindblad-Toh K. The African coelacanth genome provides insights into tetrapod evolution. Nature. 2013 Apr 18;496(7445):311-6. doi: 10.1038/nature12027. PMID: 23598338 / PMC3633110

  2. Amemiya CT, Wagner GP. Francis (frank) hugh ruddle (1929-2013). J Exp Zool B Mol Dev Evol. 2013 Jul;320(5):273-5. doi: 10.1002/jez.b.22509. PMID: 23650107

  3. Chiche L, Jourde-Chiche N, Pascual V, Chaussabel D. Current perspectives on systems immunology approaches to rheumatic diseases. Arthritis Rheum. 2013 Jun;65(6):1407-17. doi: 10.1002/art.37909. PMID: 23450649

  4. Duhen R, Glatigny S, Arbelaez CA, Blair TC, Oukka M, Bettelli E. Cutting Edge: the pathogenicity of IFN-γ-producing Th17 cells is independent of T-bet. J Immunol. 2013 May 1;190(9):4478-82. doi: 10.4049/jimmunol.1203172. Epub 2013 Mar 29. PMID: 23543757

  5. Handa P, Kowdley KV. Dendritic cells in NASH: friend or foe? Ann Hepatol. 2013 May-Jun;12(3):508-9. PMID: 23619272

  6. Hoofnagle JH, Van Natta ML, Kleiner DE, Clark JM, Kowdley KV, Loomba R, Neuschwander-Tetri BA, Sanyal AJ, Tonascia J; Non-alcoholic Steatohepatitis Clinical Research Network [Nelson JE]. Vitamin E and changes in serum alanine aminotransferase levels in patients with non-alcoholic steatohepatitis. Aliment Pharmacol Ther. 2013 Jul;38(2):134-43. doi: 10.1111/apt.12352. PMID: 23718573

  7. Huang C, Martin S, Pfleger C, Du J, Buckner JH, Bluestone JA, Riley JL, Ziegler SF. Cutting Edge: a novel, human-specific interacting protein couples FOXP3 to a chromatin-remodeling complex that contains KAP1/TRIM28. J Immunol. 2013 May 1;190(9):4470-3. doi: 10.4049/jimmunol.1203561. Epub 2013 Mar 29. PMID: 23543754

  8. Jacobson IM, Gordon SC, Kowdley KV, Yoshida EM, Rodriguez-Torres M, Sulkowski MS, Shiffman ML, Lawitz E, Everson G, Bennett M, Schiff E, Al-Assi MT, Subramanian GM, An D, Lin M, McNally J, Brainard D, Symonds WT, McHutchison JG, Patel K, Feld J, Pianko S, Nelson DR; POSITRON Study; FUSION Study. Sofosbuvir for hepatitis C genotype 2 or 3 in patients without treatment options. N Engl J Med. 2013 May 16;368(20):1867-77. doi: 10.1056/NEJMoa1214854. PMID: 23607593

  9. Kowdley KV, Lawitz E, Crespo I, Hassanein T, Davis MN, DeMicco M, Bernstein DE, Afdhal N, Vierling JM, Gordon SC, Anderson JK, Hyland RH, Dvory-Sobol H, An D, Hindes RG, Albanis E, Symonds WT, Berrey MM, Nelson DR, Jacobson IM. Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial. Lancet. 2013 Jun 15;381(9883):2100-7. doi: 10.1016/S0140-6736(13)60247-0. PMID: 23499440

  10. Kowdley KV, Nelson J. Reply. Hepatology. 2013 May;57(5):2095. doi: 10.1002/hep.26073. PMID: 22987775

  11. Larson RP, Comeau MR, Ziegler SF. Cutting edge: allergen-specific CD4 T cells respond indirectly to thymic stromal lymphopoietin to promote allergic responses in the skin. J Immunol. 2013 May 1;190(9):4474-7. doi: 10.4049/jimmunol.1201677. Epub 2013 Mar 29. PMID: 23543759 / PMC3657711

  12. Lawitz E, Lalezari JP, Hassanein T, Kowdley KV, Poordad FF, Sheikh AM, Afdhal NH, Bernstein DE, Dejesus E, Freilich B, Nelson DR, Dieterich DT, Jacobson IM, Jensen D, Abrams GA, Darling JM, Rodriguez-Torres M, Reddy KR, Sulkowski MS, Bzowej NH, Hyland RH, Mo H, Lin M, Mader M, Hindes R, Albanis E, Symonds WT, Berrey MM, Muir A. Sofosbuvir in combination with peginterferon alfa-2a and ribavirin for non-cirrhotic, treatment-naive patients with genotypes 1, 2, and 3 hepatitis C infection: a randomised, double-blind, phase 2 trial. Lancet Infect Dis. 2013 May;13(5):401-8. doi: 10.1016/S1473-3099(13)70033-1. PMID: 23499158

  13. Lawitz E, Mangia A, Wyles D, Rodriguez-Torres M, Hassanein T, Gordon SC, Schultz M, Davis MN, Kayali Z, Reddy KR, Jacobson IM, Kowdley KV, Nyberg L, Subramanian GM, Hyland RH, Arterburn S, Jiang D, McNally J, Brainard D, Symonds WT, McHutchison JG, Sheikh AM, Younossi Z, Gane EJ. Sofosbuvir for previously untreated chronic hepatitis C infection. N Engl J Med. 2013 May 16;368(20):1878-87. doi: 10.1056/NEJMoa1214853. PMID: 23607594

  14. Li X, Xu F, Karoopongse E, Marcondes AM, Lee K, Kowdley KV, Miao CH, Trobridge GD, Campbell JS, Deeg HJ. Allogeneic Transplantations, Fas Signaling, and Dysregulation of Hepcidin. Biol Blood Marrow Transplant. 2013 May 22. pii: S1083-8791(13)00225-5. doi: 10.1016/j.bbmt.2013.05.012. PMID: 23707854

  15. Matta J, Baratin M, Chiche L, Forel JM, Cognet C, Thomas G, Farnarier C, Piperoglou C, Papazian L, Chaussabel D, Ugolini S, Vély F, Vivier E. Induction of B7-H6, a ligand for the Natural Killer cell activating receptor NKp30, in inflammatory conditions. Blood. 2013 May 17. [Epub ahead of print] PMID: 23687088

  16. Messner DJ, Rhieu BH, Kowdley KV. Iron Overload Causes Oxidative Stress and Impaired Insulin Signaling in AML-12 Hepatocytes. Dig Dis Sci. 2013 Jul;58(7):1899-908. doi: 10.1007/s10620-013-2648-3. PMID: 23558563 / PMC3700657

  17. Miazgowicz MM, Elliott MS, Debley JS, Ziegler SF. Respiratory syncytial virus induces functional thymic stromal lymphopoietin receptor in airway epithelial cells. J Inflamm Res. 2013;6:53-61. doi: 10.2147/JIR.S42381. Epub 2013 Mar 24. PMID: 23576878 / PMC3617816

  18. Obermoser G, Presnell S, Domico K, Xu H, Wang Y, Anguiano E, Thompson-Snipes L, Ranganathan R, Zeitner B, Bjork A, Anderson D, Speake C, Ruchaud E, Skinner J, Alsina L, Sharma M, Dutartre H, Cepika A, Israelsson E, Nguyen P, Nguyen QA, Harrod AC, Zurawski SM, Pascual V, Ueno H, Nepom GT, Quinn C, Blankenship D, Palucka K, Banchereau J, Chaussabel D. Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines. Immunity. 2013 Apr 18;38(4):831-44. doi: 10.1016/j.immuni.2012.12.008. PMID: 23601689

  19. Peng SL, Rodriguez D. Abatacept in relapsing polychondritis. Ann Rheum Dis. 2013 Aug;72(8):1427-9. doi: 10.1136/annrheumdis-2013-203319. Epub 2013 Apr 20. PMID: 23606702

  20. Rudensky AY, Campbell DJ. In vivo sites and cellular mechanisms of T reg cell-mediated suppression. J Exp Med. 2006 Mar 20;203(3):489-92. Epub 2006 Mar 13. PMID: 16533888

  21. Shaffer HB, Minx P, Warren DE, Shedlock AM, Thomson RC, Valenzuela N, Abramyan J, Amemiya CT, Badenhorst D, Biggar KK, Borchert GM, Botka CW, Bowden RM, Braun EL, Bronikowski AM, Bruneau BG, Buck LT, Capel B, Castoe TA, Czerwinski M, Delehaunty KD, Edwards SV, Fronick CC, Fujita MK, Fulton L, Graves TA, Green RE, Haerty W, Hariharan R, Hernandez O, Hillier LW, Holloway AK, Janes D, Janzen FJ, Kandoth C, Kong L, de Koning AJ, Li Y, Literman R, McGaugh SE, Mork L, O'Laughlin M, Paitz RT, Pollock DD, Ponting CP, Radhakrishnan S, Raney BJ, Richman JM, St John J, Schwartz T, Sethuraman A, Spinks PQ, Storey KB, Thane N, Vinar T, Zimmerman LM, Warren WC, Mardis ER, Wilson RK. The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage. Genome Biol. 2013 Mar 28;14(3):R28. PMID: 23537068

  22. Shah N, Pierce T, Kowdley KV. Review of direct-acting antiviral agents for the treatment of chronic hepatitis C. Expert Opin Investig Drugs. 2013 Jun 4. [Epub ahead of print] PMID: 23735127

  23. Sulkowski MS, Poordad F, Manns MP, Bronowicki JP, Rajender Reddy K, Harrison SA, Afdhal NH, Sings HL, Pedicone LD, Koury KJ, Sniukiene V, Burroughs MH, Albrecht JK, Brass CA, Jacobson IM; SPRINT-2 Trial Investigators [Kowdley KV] Anemia during treatment with peginterferon Alfa-2b/ribavirin and boceprevir: Analysis from the serine protease inhibitor therapy 2 (SPRINT-2) trial. Hepatology. 2013 Mar;57(3):974-84. doi: 10.1002/hep.26096. PMID: 23081753

  24. Tong MJ, Kowdley KV, Pan C, Hu KQ, Chang TT, Han KH, Yoon SK, Goodman ZD, Beebe S, Iloeje U, Tang H. Improvement in liver histology among Asian patients with chronic hepatitis B after long-term treatment with entecavir. Liver Int. 2013 Apr;33(4):650-1. doi: 10.1111/liv.12121. PMID: 23489906

  25. Vuppalanchi R, Troutt JS, Konrad RJ, Ghabril M, Saxena R, Bell LN, Kowdley KV, Chalasani N. Serum hepcidin levels are associated with obesity but not liver disease. Obesity (Silver Spring). 2013 Mar 20. doi: 10.1002/oby.20403. PMID: 23512600 / PMC3692602

From December 2012 - February 2013

  1. Bell BD, Kitajima M, Larson RP, Stoklasek TA, Dang K, Sakamoto K, Wagner KU, Reizis B, Hennighausen L, Ziegler SF. The transcription factor STAT5 is critical in dendritic cells for the development of T(H)2 but not T(H)1 responses. Nat Immunol. 2013 Feb 24. doi: 10.1038/ni.2541. [Epub ahead of print] PMID: 23435120

  2. Bonvalet M, Moussu H, Wambre E, Ricarte C, Horiot S, Rimaniol AC, Kwok WW, Horak F, de Beaumont O, Baron-Bodo V, Moingeon P. Allergen-specific CD4(+) T cell responses in peripheral blood do not predict the early onset of clinical efficacy during grass pollen sublingual immunotherapy. Clin Exp Allergy. 2012 Dec;42(12):1745-55. doi: 10.1111/cea.12015. PMID: 23181790

  3. Boyd A, Bennuru S, Wang Y, Sanprasert V, Law M, Chaussabel D, Nutman TB, Semnani RT. Quiescent Innate Response to Infective Filariae by Human Langerhans Cells Suggests a Strategy of Immune Evasion. Infect Immun. 2013 Feb 19. [Epub ahead of print] PMID: 23429540

  4. Buechler MB, Teal TH, Elkon KB, Hamerman JA. Cutting edge: Type I IFN drives emergency myelopoiesis and peripheral myeloid expansion during chronic TLR7 signaling. J Immunol. 2013 Feb 1;190(3):886-91. doi: 10.4049/jimmunol.1202739. Epub 2013 Jan 9. PMID: 23303674

  5. Chau JP, Chung LC, Wong RY, Loo KM, Lo SH, So TT, Lau MS, Yeung TH, Leung BS, Tong ML, Li CY, Kwok WW, Thompson DR, Lee DT. An Evaluation of a Web-Based Diabetes Education Program Designed to Enhance Self-management Among Patients Living With Diabetes. Comput Inform Nurs. 2012 Dec;30(12):672-679. PMID: 22872044

  6. Chujo D, Foucat E, Nguyen TS, Chaussabel D, Banchereau J, Ueno H. ZnT8-Specific CD4(+) T Cells Display Distinct Cytokine Expression Profiles between Type 1 Diabetes Patients and Healthy Adults. PLoS One. 2013;8(2):e55595. doi: 10.1371/journal.pone.0055595. PMID: 23390544

  7. Corn DJ, Kim Y, Krebs MD, Mounts T, Molter J, Gerson S, Alsberg E, Dennis JE, Lee Z. Imaging Early Stage Osteogenic Differentiation of Mesenchymal Stem Cells. J Orthop Res. 2013 Feb 25. doi: 10.1002/jor.22328. [Epub ahead of print] PMID: 23440976

  8. Dunn W, Sanyal AJ, Brunt EM, Unalp-Arida A, Donohue M, McCullough AJ, and Schwimmer JB; for the Nonalcoholic Steatohepatitis Clinical Research Network [Kowdley KV, Nelson JE]. Modest alcohol consumption is associated with decreased prevalence of steatohepatitis in patients with nonalcoholic fatty liver disease (NAFLD). J Hepatol 2012 Aug;57(2):384-91. PMID: 22521357

  9. Greenbaum CJ, Schatz DA, Haller MJ, Sanda S. Response to Comment on: Greenbaum et al. Through the Fog: Recent Clinical Trials to Preserve Beta-Cell Function in Type 1 Diabetes. Diabetes 2012;61:1323-1330. Diabetes. 2012 Dec;61(12):e19. doi: 10.2337/db12-0914. PMID: 23172965

  10. Guerrerio AL, Colvin RM, Schwartz AK, Molleston JP, Murray KF, Diehl A, Mohan P, Schwimmer JB, Lavine JE, Torbenson MS, Scheimann AO; for the NASH CRN [Kowdley KV, Nelson JE]. Choline intake in a large cohort of patients with nonalcoholic fatty liver disease. Am J Clin Nutr, 2012 Apr;95(4):892-900. PMID: 22338037 (not previously reported in 2012)

  11. Han H, Headley MB, Xu W, Comeau MR, Zhou B, Ziegler SF. Thymic Stromal Lymphopoietin Amplifies the Differentiation of Alternatively Activated Macrophages. J Immunol. 2012 Dec 28. [Epub ahead of print] PMID: 23275605

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