Publications

The following list highlights BRI's 2018 publications. More selective listings of publications are also included on scientist biography pages. Featured BRI Principal Investigators are listed in bold.

  1. Carmona-Rivera C, Bicker KL, Thompson PR, Buckner JH, Robinson WH, Fox DA, Kaplan MJ. Response to comment on "Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis". Sci Immunol. 2018  Mar 30;3(21). pii: eaar3701. doi: 10.1126/sciimmunol.aar3701. PMID: 29602804

  2. Kimura T, Kobiyama K, Winkels H, Tse K, Miller J, Vassallo M, Wolf D, Ryden C, Orecchioni M, Dileepan T, Jenkins MK, James EA, Kwok WW, Hanna DB, Kaplan RC, Strickler HD, Durkin HG, Kassaye SG, Karim R, Tien PC, Landay AL, Gange SJ, Sidney J, Sette A, Ley K. Regulatory CD4(+) T Cells Recognize MHC-II-Restricted Peptide Epitopes of Apolipoprotein B. Circulation. 2018 Mar 27. pii:CIRCULATIONAHA.117.031420. doi: 10.1161/CIRCULATIONAHA.117.031420. PMID: 29588316

  3. Bingley PJ, Wherrett DK, Shultz A, Rafkin LE, Atkinson MA, Greenbaum CJ. Type 1 Diabetes TrialNet: A Multifaceted Approach to Bringing Disease-Modifying Therapy to Clinical Use in Type 1 Diabetes. Diabetes Care. 2018 Apr;41(4):653-661. doi: 10.2337/dc17-0806. PMID: 29559451 | PMC5860837

  4. Kuan EL, Ziegler SF. A tumor-myeloid cell axis, mediated via the cytokines IL-1α and TSLP, promotes the progression of breast cancer. Nat Immunol. 2018 Apr;19(4):366-374. doi: 10.1038/s41590-018-0066-6. Epub 2018 Mar 19. PMID: 29556001 | PMC5864553

  5. Altman MC, Whalen E, Togias A, O'Connor GT, Bacharier LB, Bloomberg GR, Kattan M, Wood RA, Presnell S, LeBeau P, Jaffee K, Visness CM, Busse WW, Gern JE. Allergen-induced activation of natural killer cells represents an early-life immune response in the development of allergic asthma. J Allergy Clin Immunol. 2018 Mar 5. pii: S0091-6749(18)30307-5. doi: 10.1016/j.jaci.2018.02.019. PMID: 29518416

  6. Wight TN. A role for proteoglycans in vascular disease. Matrix Biol. 2018 Feb 27. pii: S0945-053X(18)30037-4. doi: 10.1016/j.matbio.2018.02.019. Review. PMID: 29499356

  7. Kanter JE, Kramer F, Barnhart S, Duggan JM, Shimizu-Albergine M, Kothari V, Chait A, Bouman SD, Hamerman JA, Hansen BF, Olsen GS, Bornfeldt KE. A Novel Strategy to Prevent Advanced Atherosclerosis and Lower Blood Glucose in a Mouse Model of Metabolic Syndrome. Diabetes. 2018 Feb 26. pii: db170744. doi: 10.2337/db17-0744. PMID: 29483182 | PMC5909997

  8. Weir GC, Ehlers MR, Harris KM, Kanaparthi S, Long A, Phippard D, Weiner LJ, Jepson B, McNamara JG, Koulmanda M, Strom TB; ITN RETAIN Study Team. Alpha-1 antitrypsin treatment of new-onset type 1 diabetes: an open-label, phase I clinical trial (RETAIN) to assess safety and pharmacokinetics. Pediatr Diabetes. 2018 Feb 23. doi: 10.1111/pedi.12660. PMID: 29473705 | PMC6030471

  9. Ettinger RA, Liberman JA, Gunasekera D, Puranik K, James EA, Thompson AR, Pratt KP. FVIII proteins with a modified immunodominant T-cell epitope exhibit reduced immunogenicity and normal FVIII activity. Blood Adv. 2018 Feb 27;2(4):309-322. doi: 10.1182/bloodadvances.2017013482. PMID: 29444872 | PMC5858479

  10. Culina S, Lalanne AI, Afonso G, Cerosaletti K, Pinto S, Sebastiani G, Kuranda K, Nigi L, Eugster A, Østerbye T, Maugein A, McLaren JE, Ladell K, Larger E, Beressi JP, Lissina A, Appay V, Davidson HW, Buus S, Price DA, Kuhn M, Bonifacio E, Battaglia M, Caillat-Zucman S, Dotta F, Scharfmann R, Kyewski B, Mallone R; ImMaDiab Study Group, Carel JC, Tubiana-Rufi N, Martinerie L, Poidvin A, JacqzAigrain E, Corvez L, Berruer V, Gautier JF, Baz B, Haddadi N, Andreelli F, Amouyal C, Jaqueminet S, Bourron O, Dasque E, Hartemann A, Lemoine-Yazigi A, Dubois-Laforgue D, Travert F, Feron M, Rolland P, Vignali V, Marre M, Chanson P, Briet C, Guillausseau PJ, Ait-Bachir L, Collet C, Beziaud F, Desforges-Bullet V, Petit-Aubert G, Christin-Maitre S, Fève B, Vatier C, Bourcigaux N, Lautridou C, Lahlou N, Bakouboula P, Elie C, Morel H, Treluyer JM, Gagnerault MC, Maillard C, Jones A. Islet-reactive CD8(+) T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors. Sci Immunol. 2018 Feb 2;3(20). pii: eaao4013. doi: 10.1126/sciimmunol.aao4013. PMID: 29429978 | PMC5874133

  11. DeBerg HA, Zaidi MB, Altman MC, Khaenam P, Gersuk VH, Campos FD, Perez-Martinez I, Meza-Segura M, Chaussabel D, Banchereau J, Estrada-Garcia T, Linsley PS. Shared and organism-specific host responses to childhood diarrheal diseases revealed by whole blood transcript profiling. PLoS One. 2018 Jan 29;13(1):e0192082. doi: 10.1371/journal.pone.0192082. eCollection 2018. PMID: 29377961 | PMC5788382

  12. Boden EK, Shows DM, Chiorean MV, Lord JD. Identification of Candidate Biomarkers Associated with Response to Vedolizumab in Inflammatory Bowel Disease. Dig Dis Sci. 2018 Jan 25. doi: 10.1007/s10620-018-4924-8. PMID: 29372476

  13. Hahn WO, Butler NS, Lindner SE, Akilesh HM, Sather DN, Kappe SH, Hamerman JA, Gale M Jr., Liles WC, Pepper M. cGAS-mediated control of blood-stage malaria promotes Plasmodium-specific germinal center responses. JCI Insight. 2018 Jan 25;3(2). pii: 94142. doi: 10.1172/jci.insight.94142. PMID: 29367469 | PMC5821207

  14. Veatch JR, Lee SM, Fitzgibbon M, Chow IT, Jesernig B, Schmitt T, Kong YY, Kargl J, Houghton AM, Thompson JA, McIntosh M, Kwok WW, Riddell SR. Tumor-infiltrating BRAFV600E-specific CD4+ T cells correlated with complete clinical response in melanoma. J Clin Invest. 2018 Apr 2;128(4):1563-1568. doi: 10.1172/JCI98689. Epub 2018 Mar 12. PMID: 29360643 | PMC5873881

  15. Smith JJ, Timoshevskaya N, Ye C, Holt C, Keinath MC, Parker HJ, Cook ME, Hess JE, Narum SR, Lamanna F, Kaessmann H, Timoshevskiy VA, Waterbury CKM, Saraceno C, Wiedemann LM, Robb SMC, Baker C, Eichler EE, Hockman D, Sauka-Spengler T, Yandell M, Krumlauf R, Elgar G, Amemiya CT. The sea lamprey germline genome provides insights into programmed genome rearrangement and vertebrate evolution. Nat Genet. 2018 Feb;50(2):270-277. doi: 10.1038/s41588-017-0036-1. Epub 2018 Jan 22. PMID: 29358652 | PMC5805609

  16. Reynolds CJ, Suleyman OM, Ortega-Prieto AM, Skelton JK, Bonnesoeur P, Blohm A, Carregaro V, Silva JS, James EA, Maillère B, Dorner M, Boyton RJ, Altmann DM.  T cell immunity to Zika virus targets immunodominant epitopes that show cross-reactivity with other Flaviviruses. Sci Rep. 2018 Jan 12;8(1):672. doi: 10.1038/s41598-017-18781-1. PMID: 29330423 | PMC5766511

  17. Kang I, Chang MY, Wight TN, Frevert CW. Proteoglycans as Immunomodulators of  the Innate Immune Response to Lung Infection. J Histochem Cytochem. 2018 Apr;66(4):241-259. doi: 10.1369/0022155417751880. Epub 2018 Jan 12. PMID: 29328866 | PMC5958380

  18. Glatigny S, Bettelli E. Experimental Autoimmune Encephalomyelitis (EAE) as Animal Models of Multiple Sclerosis (MS). Cold Spring Harb Perspect Med. 2018 Jan 8. pii: a028977. doi: 10.1101/cshperspect.a028977. PMID: 29311122

  19. Evanko SP, Chan CK, Johnson PY, Frevert CW, Wight TN. The biochemistry and immunohistochemistry of versican. Methods Cell Biol. 2018;143:261-279. doi: 10.1016/bs.mcb.2017.08.015. Epub 2017 Nov 26. PMID: 29310782

  20. Muehling LM, Turner RB, Brown KB, Wright PW, Patrie JT, Lahtinen SJ, Lehtinen MJ, Kwok WW, Woodfolk JA. Single-Cell Tracking Reveals a Role for Pre-Existing CCR5+ Memory Th1 Cells in the Control of Rhinovirus-A39 After Experimental Challenge in Humans. J Infect Dis. 2018 Jan 17;217(3):381-392. doi: 10.1093/infdis/jix514. PMID: 29309618 | PMC5853408

  21. Kulis MD, Patil SU, Wambre E, Vickery BP. Immune mechanisms of oral immunotherapy. J Allergy Clin Immunol. 2018 Feb;141(2):491-498. doi: 10.1016/j.jaci.2017.12.979. Epub 2017 Dec 26. PMID: 29288078

  22. Fisher H, Toit GD, Bahnson HT, Lack G. The Challenges of Preventing Food Allergy: lessons learned from LEAP and EAT. Ann Allergy Asthma Immunol. 2018 Jun 14. pii: S1081-1206(18)30468-X. doi: 10.1016/j.anai.2018.06.008. Review. PMID: 29909054

  23. Wall VZ, Barnhart S, Kanter JE, Kramer F, Shimizu-Albergine M, Adhikari N, Wight TN, Hall JL, Bornfeldt KE. Smooth muscle glucose metabolism promotes monocyte recruitment and atherosclerosis in a mouse model of metabolic syndrome. JCI Insight. 2018 Jun 7;3(11). pii: 96544. doi: 10.1172/jci.insight.96544. PMID: 29875324

  24. Lacher MD, Bauer G, Fury B, Graeve S, Fledderman EL, Petrie TD, Coleal-Bergum DP, Hackett T, Perotti NH, Kong YY, Kwok WW, Wagner JP, Wiseman CL, Williams WV. SV-BR-1-GM, a Clinically Effective GM-CSF-Secreting Breast Cancer Cell Line, Expresses an Immune Signature and Directly Activates CD4+ T Lymphocytes. Front Immunol. 2018 May 15;9:776. doi: 10.3389/fimmu.2018.00776. eCollection 2018. PMID: 29867922 | PMC5962696

  25. Lord JD, Long SA, Shows DM, Thorpe J, Schwedhelm K, Chen J, Kita M, Buckner JH. Circulating integrin alpha4/beta7+ lymphocytes targeted by vedolizumab have a pro-inflammatory phenotype. Clin Immunol. 2018 May 26;193:24-32. doi: 10.1016/j.clim.2018.05.006. PMID: 29842945

  26. James EA, Pietropaolo M, Mamula MJ. Immune Recognition of β-Cells: Neoepitopes as Key Players in the Loss of Tolerance. Diabetes. 2018 Jun;67(6):1035-1042. doi: 10.2337/dbi17-0030. PMID: 29784651 | PMC5961411

  27. Reed MJ, Damodarasamy M, Pathan JL, Erickson MA, Banks WA, Vernon RB. The Effects of Normal Aging on Regional Accumulation of Hyaluronan and Chondroitin Sulfate Proteoglycans in the Mouse Brain. J Histochem Cytochem. 2018 May 1:22155418774779. doi: 10.1369/0022155418774779. PMID: 29782809

  28. Du J, Wang Q, Ziegler SF, Zhou B. FOXP3 interacts with hnRNP F to modulate pre-mRNA alternative splicing. J Biol Chem. 2018 May 17. pii: jbc.RA117.001349. doi: 10.1074/jbc.RA117.001349. PMID: 29773655 | PMC6028976

  29. Morrell ED, Wiedeman A, Long SA, Gharib SA, West TE, Skerrett SJ, Wurfel MM, Mikacenic C. Cytometry TOF identifies alveolar macrophage subtypes in acute respiratory distress syndrome. JCI Insight. 2018 May 17;3(10). pii: 99281. doi: 10.1172/jci.insight.99281. PMID: 29769438 | PMC6012519

  30. Greenbaum CJ, Speake C, Krischer J, Buckner J, Gottlieb PA, Schatz DA, Herold KC, Atkinson MA. Strength in Numbers: Opportunities for Enhancing the Development of Effective Treatments for Type 1 Diabetes-The TrialNet Experience. Diabetes. 2018 May 16. pii: db180065. doi: 10.2337/db18-0065. PMID: 29769238 | PMC6014559

  31. Gebe JA, Preisinger A, Gooden MD, D'Amico LA, Vernon RB. Local, Controlled Release In Vivo of Vascular Endothelial Growth Factor Within a Subcutaneous Scaffolded Islet Implant Reduces Early Islet Necrosis and Improves Performance of the Graft. Cell Transplant. 2018 Mar;27(3):531-541. doi: 10.1177/0963689718754562. Epub 2018 May 14. PMID: 29756517 | PMC6038045

  32. Santos AF, Couto-Francisco N, Bécares N, Kwok M, Bahnson HT, Lack G. A novel human mast cell activation test for peanut allergy. J Allergy Clin Immunol. 2018 May 3. pii: S0091-6749(18)30518-9. doi: 10.1016/j.jaci.2018.03.011. PMID: 29731128

  33. Sobel M, Kikuchi S, Chen L, Tang GL, Wight TN, Kenagy RD. Clinical factors that influence the cellular responses of saphenous veins used for arterial bypass. J Vasc Surg. 2018 Jun 15. pii: S0741-5214(18)31029-2. doi: 10.1016/j.jvs.2018.03.436. PMID: 29914830

  34. Tanaka S, Pfleger C, Lai JF, Roan F, Sun SC, Ziegler SF. KAP1 Regulates Regulatory T Cell Function and Proliferation in Both Foxp3-Dependent and -Independent Manners. Cell Rep. 2018 Apr 17;23(3):796-807. doi: 10.1016/j.celrep.2018.03.099. PMID: 29669285 | PMC5947873

  35. Marre ML, McGinty JW, Chow IT, DeNicola ME, Beck NW, Kent SC, Powers AC, Bottino R, Harlan DM, Greenbaum CJ, Kwok WW, Piganelli JD, James EA. Modifying Enzymes are Elicited by ER Stress, Generating Epitopes that are Selectively Recognized by CD4+ T Cells in Patients With Type 1 Diabetes. Diabetes. 2018 Apr 13. pii: db171166. doi: 10.2337/db17-1166. PMID: 29654212 | PMC6014552

  36. Wang Y, Sosinowski T, Novikov A, Crawford F, Neau DB, Yang J, Kwok WW, Marrack P, Kappler JW, Dai S. C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes. Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):162-167. doi: 10.1073/pnas.1716527115. Epub 2017 Dec 18. PMID: 29255035 | PMC5776820

  37. Nowak-Węgrzyn A, Lawson K, Masilamani M, Kattan J, Bahnson HT, Sampson HA. Increased Tolerance to Less Extensively Heat-Denatured (Baked) Milk Products in Milk-Allergic Children. J Allergy Clin Immunol Pract. 2018 Mar - Apr;6(2):486-495.e5. doi: 10.1016/j.jaip.2017.10.021. Epub 2017 Dec 7. PMID: 29226808 | PMC5881948

  38. James EA, Abreu JRF, McGinty JW, Odegard JM, Fillié YE, Hocter CN, Culina S, Ladell K, Price DA, Alkanani A, Rihanek M, Fitzgerald-Miller L, Skowera A, Speake C, Gottlieb P, Davidson HW, Wong FS, Roep B, Mallone R; Immunology of Diabetes Society T Cell Workshop Committee. Combinatorial detection of autoreactive CD8(+) T cells with HLA-A2 multimers: a multi-centre study by the Immunology of Diabetes Society T Cell Workshop. Diabetologia. 2018 Mar;61(3):658-670. doi:10.1007/s00125-017-4508-8. Epub 2017 Dec 1. PMID: 29196783

  39. Nagy N, de la Zerda A, Kaber G, Johnson PY, Hu KH, Kratochvil MJ, Yadava K, Zhao W, Cui Y, Navarro G, Annes JP, Wight TN, Heilshorn SC, Bollyky PL, Butte MJ. Hyaluronan content governs tissue stiffness in pancreatic islet inflammation. J Biol Chem. 2018 Jan 12;293(2):567-578. doi: 10.1074/jbc.RA117.000148. Epub 2017 Nov 28. PMID: 29183997 | PMC5767862

  40. Wambre E, Jeong D. Oral Tolerance Development and Maintenance. Immunol Allergy Clin North Am. 2018 Feb;38(1):27-37. doi: 10.1016/j.iac.2017.09.003. Epub 2017 Oct 26. Review. PMID: 29132672 | PMC5776674

  41. Renand A, Shamji MH, Harris KM, Qin T, Wambre E, Scadding GW, Wurtzen PA, Till SJ, Togias A, Nepom GT, Kwok WW, Durham SR. Synchronous immune alterations mirror clinical response during allergen immunotherapy. J Allergy Clin Immunol. 2018 May;141(5):1750-1760.e1. doi: 10.1016/j.jaci.2017.09.041. Epub 2017 Nov 9. PMID: 29128670 | PMC5938141

  42. Han H, Roan F, Johnston LK, Smith DE, Bryce PJ, Ziegler SF. IL-33 promotes gastrointestinal allergy in a TSLP-independent manner. Mucosal Immunol. 2018 Mar;11(2):394-403. doi: 10.1038/mi.2017.61. Epub 2017 Jun 28. Erratum in: Mucosal Immunol. 2017 Oct 25. PMID: 28656964 | PMC5745299

  43. Kikuchi S, Chen L, Xiong K, Saito Y, Azuma N, Tang G, Sobel M, Wight TN, Kenagy RD. Smooth muscle cells of human veins show an increased response to injury at valve sites. J Vasc Surg. 2018 May;67(5):1556-1570.e9. doi: 10.1016/j.jvs.2017.03.447. Epub 2017 Jun 21. PMID: 28647196 | PMC5740028

  44. Linsley PS, Greenbaum CJ, Rosasco M, Presnell S, Herold KC, Dufort MJ. Elevated T cell levels in peripheral blood predict poor clinical response following rituximab treatment in new-onset type 1 diabetes. Genes Immun. 2018 Jun 21. doi: 10.1038/s41435-018-0032-1. Genes Immun. 2018 Jun 21. doi: 10.1038/s41435-018-0032-1. PMID: 29925930

  45. Renand A, Farrington M, Whalen E, Wambre E, Bajzik V, Chinthrajah S, Nadeau KC, Kwok WW. Heterogeneity of Ara h Component-Specific CD4 T Cell Responses in Peanut-Allergic Subjects. Front Immunol. 2018 Jun 25;9:1408. doi: 10.3389/fimmu.2018.01408. eCollection 2018. PMID: 29988522 | PMC6026622

  46. Newton RH, Shrestha S, Sullivan JM, Yates KB, Compeer EB, Ron-Harel N, Blazar BR, Bensinger SJ, Haining WN, Dustin ML, Campbell DJ, Chi H, Turka LA. Maintenance of CD4 T cell fitness through regulation of Foxo1. Nat Immunol. 2018 Jul 9. doi: 10.1038/s41590-018-0157-4. PMID: 29988091

  47. Klicznik MM, Szenes-Nagy AB, Campbell DJ, Gratz IK. Taking the lead - how keratinocytes orchestrate skin T cell immunity. Immunol Lett. 2018 Jun 30;200:43-51. doi: 10.1016/j.imlet.2018.06.009. Review. PMID: 29969603

  48. Goddard TD, Brilliant AA, Skillman TL, Vergenz S, Tyrwhitt-Drake J, Meng EC, Ferrin TE. Molecular Visualization on the Holodeck. J Mol Biol. 2018 Jun 28. pii: S0022-2836(18)30696-X. doi: 10.1016/j.jmb.2018.06.040. Review. PMID: 29964044

  49. Stefani C, Lacy-Hulbert A, Skillman TConfocalVR: Immersive Visualization Applied to Confocal Microscopy. J Mol Biol. 2018 Jun 24. pii: S0022-2836(18)30664-8. doi: 10.1016/j.jmb.2018.06.035. PMID: 29949752