Bolouri Lab


The Bolouri lab is interested in developing and applying computational systems immunology methods to better understand dysregulated immune cell development and differentiation.

Our approach is inherently multi- and cross-disciplinary. We integrate biological and immunological knowledge with data from high-throughput assays using machine-learning, neural networks and other Data Science methods derived from computer science, engineering, mathematics, statistics and physics.

To get a more complete picture of the system of interest, we typically integrate data from diverse assays (e.g. single-cell RNAseq, CITE-seq, single-cell ATAC-seq, flow and mass cytometry, etc.) with patient clinical data and curated data from databases and publications.

Hamid Bolouri
Associate Member

Hamid Bolouri, PhD

Associate Member, Center for Systems Immunology; Principal Investigator, Bolouri Lab; Affiliate Faculty, Division of Human Biology, Fred Hutchinson Cancer Research Center
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Research Projects

Bolouri Research Project Preview Image - Approach Semi-supervised

Bias-aware data integration

We correct for known assay-specific biases before multi-modal data integration.
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Bolouri Research Project Preview - Adverse Inflamm Signaling

Inflammatory signaling in pediatric Acute Myeloid Leukemia

Inflammatory signaling dysregulates the development of myeloid cells in the bone marrow and marks resistance to chemotherapy.
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Inferring Gene Reg Networks Preview Image

Regulation of blood homeostasis

What are the regulatory mechanisms that maintain highly stable immune cell frequencies in the blood?
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Related Stories

Blog Main Image - Paper DNA Profile People
March 14, 2023

Computer Science Reveals Possible Drug Target for Deadly Childhood Leukemia

Dr. Bolouri is an expert in using computer science to advance biomedical research. Working with Soheil Meshinchi, MD, PhD, and his team at Fred Hutch Cancer Center, they made a recent discovery that may lead to new treatments for certain forms of pediatric acute myeloid leukemia (AML).
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Blog Main Image - BRI Scientific Circle CIRCOS Plot
July 10, 2020

A Revolutionary Way to Study the Immune System

One goal is to find markers that identify why some people with the virus don’t have symptoms while others get fatally ill. The sickest patients tend to have multiple health issues, which makes it hard to pinpoint the factors related to COVID-19.

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Blog Main Image - Man Coding Single Screen
May 5, 2020

The Man Behind the Data: Hamid Bolouri, PhD

Dr. Bolouri joined BRI’s growing Systems Immunology Division this year. Much of his work explores why some people have one immune response to an external or internal event, while other people have a different response. He and his systems immunology colleagues examine the big picture.

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News Medical Life Sciences

Pediatric acute myeloid leukemia genetic subtypes with poor outcomes show increased inflammatory cytokine signaling

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Blog Main Image - Paper DNA Profile People

Hamid Bolouri, PhD, named Associate Member in the Center for Systems Immunology at Benaroya Research Institute at Virginia Mason

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