Michael Kinsella, Kathleen Braun, Sean Ibarrientos, Gernot Kaber
Dr. Kinsella leads research efforts to understand how the extracellular matrix within tissue regulates vascular and immune cell responses during development, injury, inflammation and disease. The Kinsella Laboratory has extensive experience in analysis and chemical modification of heparin/heparan sulfates, which have been used in in vitro and in vivo models of cell behavior and experimental disease. In addition, since extracellular matrix components such as versican and hyaluronan are synthesized during acute and chronic inflammatory diseases, the lab team has designed molecular tools, including retrovirally-mediated expression in vivo and in vitro as well as transgenic and knock-out animal models, to examine the roles of these molecules during vascular injury and in experimental models of lung inflammation. The Kinsella Laboratory studies of the regulation of vascular tissue structure has recently led to the development of recombinant protein expression systems for production of versican-related proteins that may allow scientists to regulate the structure, resiliency and patency of engineered vessel replacements.
The Kinsella Lab
Michael Kinsella, PhD
Gernot Kaber, PhD