Our Research
Kris Kowdley, MD
Title:
Clinical Investigator
Phone Number:
206-287-1083
Background
Kris V. Kowdley, MD, FACP, FACG, FGAF, is the Director of the Liver Center of Excellence in the Digestive Disease Institute at Virginia Mason Medical Center, Clinical Professor of Medicine at the University of Washington in Seattle, and Clinical Investigator at BRI. Dr. Kowdley received his BS in Biology and Anthropology as a member of the Dean’s List at Columbia University, and his medical degree from Mount Sinai School of Medicine. He completed his internship and residency at Oregon Health Science University and a Fellowship in Gastroenterology and Hepatology at Tufts University School of Medicine. Dr. Kowdley has presented his research in liver diseases at more than 125 national and international medical centers and scientific symposia. He is the author of over 325 articles, book chapters, reviews and commentaries in this area, and has been published in the New England Journal of Medicine, Annals of Internal Medicine, Hepatology, Gastroenterology, Archives of Surgery, Journal of Clinical Gastroenterology, among other professional publications.
Selected Publications
Kowdley KV, Lawitz E, Crespo I, Hassanein T, Davis MN, Demicco M, BernsteinDE, Afdhal N, Vierling JM, Gordon SC, Anderson JK, Hyland RH, Dvory-Sobol H, An D, Hindes RG, Albanis E, Symonds WT, Berrey MM, Nelson DR, Jacobson IM. Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naïve patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial. Lancet. 2013 Mar 14. doi:pii: S0140-6736(13)60247-0. 10.1016/S0140-6736(13)60247-0. [Epub ahead of print] PMID: 23499440.
Maliken BD, Nelson JE, Klintworth HM, Beauchamp M, Yeh MM, Kowdley KV. Hepatic reticuloendothelial system cell iron deposition is associated with increased apoptosis in nonalcoholic fatty liver disease. Hepatology. 2013 Jan 16. doi: 10.1002/hep.26238. [Epub ahead of print] PMID: 23325576.
Poordad F, Lawitz E, Kowdley KV, Cohen DE, Podsadecki T, Siggelkow S, Heckaman M, Larsen L, Menon R, Koev G, Tripathi R, Pilot-Matias T, Bernstein B. Exploratory study of oral combination antiviral therapy for hepatitis C. N Engl J Med. 2013 Jan 3;368(1):45-53. PMID: 23281975.
Nelson JE, Brunt EM, Kowdley KV; Nonalcoholic Steatohepatitis Clinical Research Network. Lower serum hepcidin and greater parenchymal iron in nonalcoholic fatty liver disease patients with C282Y HFE mutations. Hepatology. 2012 Nov;56(5):1730-40. PMID: 22611049; PMCID: PMC3462887.
Kowdley KV, Belt P, Wilson LA, Yeh MM, Neuschwander-Tetri BA, Chalasani N, Sanyal AJ, Nelson JE; NASH Clinical Research Network. Serum ferritin is an independent predictor of histologic severity and advanced fibrosis in patients with nonalcoholic fatty liver disease. Hepatology. 2012 Jan;55(1):77-85. PMID: 21953442; PMCID: MC3245347.
Bacon BR, Adams PC, Kowdley KV, Powell LW, Tavill AS; American Association for the Study of Liver Diseases. Diagnosis and management of hemochromatosis: 2011 practice guideline by the American Association for the Study of Liver Diseases. Hepatology. 2011 Jul;54(1):328-43. PMID: 21452290; PMCID: PMC3149125.
Nelson JE, Wilson L, Brunt EM, Yeh MM, Kleiner DE, Unalp-Arida A, Kowdley KV; Nonalcoholic Steatohepatitis Clinical Research Network. Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease. Hepatology. 2011 Feb;53(2):448-57. PMID: 21274866; PMCID: PMC3058264.
Irani S, Kowdley K, Kozarek R. Gastric varices: an updated review of management. J Clin Gastroenterol. 2011 Feb;45(2):133-48. Review. PMID: 21135706.
Lindor KD, Kowdley KV, Luketic VA, Harrison ME, McCashland T, Befeler AS, Harnois D, Jorgensen R, Petz J, Keach J, Mooney J, Sargeant C, Braaten J, Bernard T, King D, Miceli E, Schmoll J, Hoskin T, Thapa P, Enders F. High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis. Hepatology. 2009 Sep;50(3):808-14. PMID: 19585548; PMCID: PMC2758780.
Rulyak SJ, Eng SC, Patel K, McHutchison JG, Gordon SC, Kowdley KV. Relationships between hepatic iron content and virologic response in chronic hepatitis C patients treated with interferon and ribavirin. Am J Gastroenterol. 2005 Feb;100(2):332-7. PMID: 15667490.