Jessica Hamerman, PhD
Jessica Hamerman received her BS in Biological Sciences from Stanford University and her PhD in Immunology from the University of Washington. She then pursued postdoctoral studies at the University of California San Francisco before joining the Benaroya Research Institute Immunology Program in 2006.
Areas of Research
Projects in Dr. Hamerman’s laboratory are focused on understanding the regulation of the inflammatory response of macrophages and dendritic cells, two types of white blood cells involved in the early defense against infection. Although this inflammatory response is beneficial to the host for pathogen clearance, it can be detrimental if unchecked. This can be seen in septic shock as well as in autoimmune disorders such as rheumatoid arthritis. These studies will not only help elucidate how the inflammatory response is regulated during infection, but will potentially give insights in how to manipulate the innate immune system to achieve more efficient elimination of pathogens and to regulate the inflammatory response during disease.
1. Chu CL, Yu YL, Shen KY, Lowell CA, Lanier LL, Hamerman JA. 2008. Increased TLR responses in dendritic cells lacking the ITAM-containing adapters DAP12 and FcRy., European Journal of Immunology, 38 (1), 166-73 (PMID: 18081038)
2. Hamerman JA, Jarjoura JR, Humphrey MB, Nakamura MC, Seaman WE, Lanier LL. 2006. Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12., Journal of Immunology, 177 (4), 2051-5 (PMID: 16887962)
3. Hamerman JA, Lanier LL. 2006. Inhibition of immune responses by ITAM-bearing receptors., Science's STKE : signal transduction knowledge environment, 2006 (320), re1 (PMID: 16449667)
4. Hamerman JA, Tchao NK, Lowell CA, Lanier LL. 2005. Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12., Nature Immunology, 6 (6), 579-86 (PMID: 15895090)
5. Hamerman JA, Ogasawara K, Lanier LL. 2004. Cutting Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor., Journal of Immunology, 172 (4), 2001-5 (PMID: 14764662)