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Damien Chaussabel, PhD

Title:

Director, Systems Immunology, Associate Member

Phone Number:

(206) 287-1066

Background

Dr. Chaussabel received his MS degree in biology and his PhD in immunology from the University of Brussels.  He was a fellow at the University of North Wales in Bangor and completed his post-doctoral fellowship at the National Institutes of Allergy and Infectious Diseases, Laboratory of Parasitic Diseases in Bethesda, Maryland.  In 2004, Dr. Chaussabel joined the Baylor Institute for Immunology Research in Dallas, Texas, as an Assistant Member.  In 2008, he became Associate Investigator and Director, Center for Personalized Medicine, at BIIR.  In 2010, he joined Benaroya Research Institute at Virginia Mason as an Associate Member and Director of the Systems Immunology Division.

Areas of Research

The Systems Immunology Division is organized as a research laboratory and technology platform. It encompasses several disciplines, including medicine, immunology, genomics, bioinformatics, biostatistics and software engineering. Bringing together these various disciplines allows researchers to tackle difficult questions and provides the ideal environment for educating clinicians and scientists who will become thought leaders in the field of translational research. This team leverages high throughput profiling technologies to develop novel means to assess the status of the human immune system and enable early detection of disease, complications and response to therapy.  Our team also develops innovative approaches to accelerate immunological knowledge discovery.

Chaussabel Laboratory

Dr. Chaussabel CV (PDF)

Selected Publications

  1. Obermoser G, Presnell S, Domico K, Xu H, Wang Y, Anguiano E, Thompson-Snipes L, Ranganathan R, Zeitner B, Bjork A, Anderson D, Speake C, Ruchaud E, Skinner J, Alsina L, Sharma M, Dutartre H, Cepika A, Israelsson E, Nguyen P, Nguyen QA, Harrod AC, Zurawski SM, Pascual V, Ueno H, Nepom GT, Quinn C, Blankenship D, Palucka K, Banchereau J, Chaussabel D. Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines. Immunity. 2013 Apr 18;38(4):831-44. PubMed PMID: 23601689.
  2. Chiche, L.; Jourde-Chiche, N.; Pascual, V.; Chaussabel, D. A&R special issue: Disease mechanisms in rheumatology: Tools and pathways. Arthritis Rheum. 2013 Feb 28.doi: 10.1002/art.37909. PMID: 23450649
  3. Kong, X.F.; Vogt, G.; Itan, Y.; Macura-Biegun, A.; Szaflarska, A.; Kowalczyk, D.; Chapgier, A.; Abhyankar, A.; Furthner, D.; Djambas Khayat, C.; Okada, S.; Bryant, V.L.; Bogunovic, D.; Kreins, A.; Moncada-Velez, M.; Migaud, M.; Al-Ajaji, S.; Al-Muhsen, S.; Holland, S.M.; Abel, L.; Picard, C.; Chaussabel, D.; Bustamante, J.; Casanova, J.L.; Boisson-Dupuis, S. Haploinsufficiency at the human IFNGR2 locus contributes to mycobacterial disease. Hum Mol Genet. 2013 Feb 15;22(4):769-781.doi: 10.1093/hmg/dds484. PMID: 23161749
  4. Rinchai, D.; Khaenam, P.; Kewcharoenwong, C.; Buddhisa, S.; Pankla, R.; Chaussabel, D.; Bancroft, G.J.; Lertmemongkolchai, G. Production of interleukin-27 by human neutrophils regulates their function during bacterial infection. Eur J Immunol. 2012 Dec;42(12):3280-3290.doi: 10.1002/eji.201242526. PMID: 22965735
  5. Banchereau, R.; Jordan-Villegas, A.; Ardura, M.; Mejias, A.; Baldwin, N.; Xu, H.; Saye, E.; Rossello-Urgell, J.; Nguyen, P.; Blankenship, D.; Creech, C.B.; Pascual, V.; Banchereau, J.; Chaussabel, D.; Ramilo, O. Host immune transcriptional profiles reflect the variability in clinical disease manifestations in patients with Staphylococcus aureus infections. PLoS One. 2012;7(4):e34390.doi: 10.1371/journal.pone.0034390. PMID: 22496797
  6. McNab, F.W.; Berry, M.P.; Graham, C.M.; Bloch, S.A.; Oni, T.; Wilkinson, K.A.; Wilkinson, R.J.; Kon, O.M.; Banchereau, J.; Chaussabel, D.; O'Garra, A. Programmed death ligand 1 is over-expressed by neutrophils in the blood of patients with active tuberculosis. Eur J Immunol. 2011 Jul;41(7):1941-1947.doi: 10.1002/eji.201141421. PMID: 21509782
  7. Berry MP, Graham CM, McNab FW, Xu Z, Bloch SA, Oni T, Wilkinson KA, Banchereau R, Skinner J, Wilkinson RJ, Quinn C, Blankenship D, Dhawan R, Cush JJ, Mejias A, Ramilo O, Kon OM, Pascual V, Banchereau J, Chaussabel D, O'Garra A. An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis. Nature. 2010 Aug 19;466(7309):973-7. PubMed PMID: 20725040.
  8. Chaussabel D, Pascual V, Banchereau J. Assessing the human immune system through blood transcriptomics. BMC Biol. 2010 Jul 1;8:84. Review. PubMed PMID:20619006; PubMed Central PMCID: PMC2895587.
  9. Guiducci C, Gong M, Xu Z, Gill M, Chaussabel D, Meeker T, Chan JH, Wright T, Punaro M, Bolland S, Soumelis V, Banchereau J, Coffman RL, Pascual V, Barrat FJ. TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus. Nature. 2010 Jun 17;465(7300):937-41. PubMed PMID: 20559388; PubMed Central PMCID: PMC2964153.
  10. Pascual V, Chaussabel D, Banchereau J. A genomic approach to human autoimmune diseases. Annu Rev Immunol. 2010 Mar;28:535-71. Review. PubMed PMID: 20192809; PubMed Central PMCID: PMC2847838.
  11. Chaussabel D, Ueno H, Banchereau J, Quinn C. Data management: it starts at the bench. Nat Immunol. 2009 Dec;10(12):1225-7. PubMed PMID: 19915619; PubMed Central PMCID: PMC2788787.
  12. von Bernuth H, Picard C, Jin Z, Pankla R, Xiao H, Ku CL, Chrabieh M, Mustapha IB, Ghandil P, Camcioglu Y, Vasconcelos J, Sirvent N, Guedes M, Vitor AB,
    Herrero-Mata MJ, Aróstegui JI, Rodrigo C, Alsina L, Ruiz-Ortiz E, Juan M, Fortuny C, Yagüe J, Antón J, Pascal M, Chang HH, Janniere L, Rose Y, Garty BZ, Chapel H, Issekutz A, Maródi L, Rodriguez-Gallego C, Banchereau J, Abel L, Li X, Chaussabel D, Puel A, Casanova JL. Pyogenic bacterial infections in humans with MyD88 deficiency. Science. 2008 Aug 1;321(5889):691-6. PubMed PMID: 18669862; PubMed Central PMCID: PMC2688396.
  13. Chaussabel D, Quinn C, Shen J, Patel P, Glaser C, Baldwin N, Stichweh D, Blankenship D, Li L, Munagala I, Bennett L, Allantaz F, Mejias A, Ardura M,
    Kaizer E, Monnet L, Allman W, Randall H, Johnson D, Lanier A, Punaro M, Wittkowski KM, White P, Fay J, Klintmalm G, Ramilo O, Palucka AK, Banchereau J,
    Pascual V. A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus. Immunity. 2008 Jul 18;29(1):150-64. PubMed PMID: 18631455; PubMed Central PMCID: PMC2727981.
  14. Allantaz F, Chaussabel D, Stichweh D, Bennett L, Allman W, Mejias A, Ardura M, Chung W, Smith E, Wise C, Palucka K, Ramilo O, Punaro M, Banchereau J, Pascual V. Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade. J Exp Med. 2007 Sep
    3;204(9):2131-44. Epub 2007 Aug 27. Erratum in: J Exp Med. 2009 Sep 28;206(10):2299. Smith, Elisabeth [added]. PubMed PMID: 17724127; PubMed Central PMCID: PMC2118700.
  15. Ramilo O, Allman W, Chung W, Mejias A, Ardura M, Glaser C, Wittkowski KM, Piqueras B, Banchereau J, Palucka AK, Chaussabel D. Gene expression patterns in blood leukocytes discriminate patients with acute infections. Blood. 2007 Mar 1;109(5):2066-77. Epub 2006 Nov 14. PubMed PMID: 17105821; PubMed Central PMCID: PMC1801073.
  16. Chaussabel D, Semnani RT, McDowell MA, Sacks D, Sher A, Nutman TB. Unique gene expression profiles of human macrophages and dendritic cells to
    phylogenetically distinct parasites. Blood. 2003 Jul 15;102(2):672-81. Epub 2003 Mar 27. PubMed PMID: 12663451.
  17. Chaussabel D, Sher A. Mining microarray expression data by literature profiling. Genome Biol. 2002 Sep 13;3(10):RESEARCH0055. Epub 2002 Sep 13. PubMed PMID: 12372143; PubMed Central PMCID: PMC134484.