Our Research
Scientific Papers
Current list of BRI Publications
January 2011 – December 2011
1. ALSUntangled Group (including Ravits J). ALSUntangled No. 8: Low dose naltrexone for ALS. Amyotroph Lateral Scler. 12(1):76-8. Epub 2010 Dec 21. January 2011
2. ALSUntangled Group (including Ravits J). ALSUntangled No. 9: Blue-green algae (Spirulina) as a treatment for ALS. Amyotroph Lateral Scler.12(2):153-5. March 2011
3. Angheloiu GO, Haka AS, Georgakoudi I, Arendt J, Muller MG, Scepanovic OR, Evanko SP, Wight TN, Mukherjee P, Waldeck DH, Dasari RR, Fitzmaurice M, Kramer JR, and Feld MS. Detection of coronary atherosclerotic plaques with superficial proteoglycans and foam cells using real-time intrinsic fluorescence spectroscopy Atherosclerosis 215:96-102, 2011
4. Averill MM, Barnhart S, Becker L, Li X, Heinecke JW, Leboeuf RC, Hamerman JA, Sorg C, Kerkhoff C, and Bornfeldt KE. S100A9 differentially modifies phenotypic states of neutrophils, macrophages, and dendritic cells: implications for atherosclerosis and adipose tissue inflammation Circulation 123:1216-1226, 2011
5. Bacon BR, Adams PC, Kowdley KV, Powell LW, and Tavill AS. Diagnosis and management of hemochromatosis: 2011 practice guidelines by the American association for the study of liver diseases Hepatology 2011
6. Bauer J, Liu RW, Kean TJ, Dennis JE, Petersilge W, Gilmore A. A comparison of five treatment protocols for contaminated bone grafts in reference to sterility and cell viability. J Bone Joint Surg Am. 93(5):439-44. 2011
7. Bollyky PL, Wu RP, Falk BA, Lord JD, Long SA, Preisinger A, Teng B, Holt GE, Standifer NE, Braun KR, Xie CF, Samuels PL, Vernon RB, Gebe JA, Wight TN, and Nepom GT. ECM components guide IL-10 producing regulatory T-cell (TR1) induction from effector memory T-cell precursors Proc. Natl. Acad. Sci. U. S. A 2011
8. Bonvalet M, Wambre E, Moussu H, Horiot S, Kwok WW, Louise A, Ebo D, Hoarau C, Van Overtvelt L, Baron-Bodo V, and Moingeon P. Comparison between major histocompatibility complex class II tetramer staining and surface expression of activation markers for the detection of allergen-specific CD4(+) T cells Clin. Exp. Allergy 2011
9. Boyer TD, Sanyal AJ, Garcia-Tsao G, Blei A, Carl D, Bexon AS, Teuber P; Terlipressin Study Group [Kowdley KV]. Predictors of response to terlipressin plus albumin in hepatorenal syndrome (HRS) type 1: relationship of serum creatinine to hemodynamics. J Hepatol. 2011 Aug;55(2):315-21.
10. Brooks-Worrell B, Tree T, Mannering SI, Durinovic-Belló I, James EA, Gottlieb P, Wong FS, Zhou Z, Yang L, Cilio CM, Reichow J, Menart B, Rutter R, Schreiner R, Pham M, Petrich de Marquesini L, Thorpe J, Lou O, Scotto M, Mallone R, Schloot NC. Comparison of cryopreservation methods on T-cell responses to islet and control antigens from type 1diabetic patients and controls. T-Cell Workshop Committee, Immunology of Diabetes Society. Diabetes Metab Res Rev 2011; 27: Eupub, DOI: 10.1002/dmrr.1245
11. Brunt EM, Kleiner DE, Wilson LA, Belt P, Neuschwander-Tetri BA for the NASH Clinical Research Network (CRN) [Kowdley KV]: Nonalcoholic Fatty Liver Disease (NAFLD) Activity Score and the histopathologic diagnosis in NAFLD: Distinct clinicopathologic meanings. Hepatology, 53: 810-820. 2011
12. Burke III GW, Vendrame F, Pileggi A, Ciancio G, Reijonen H, and Pugliese A. Recurrence of autoimmunity following pancreas transplantation Curr. Diab. Rep. 11:413-419, 2011
13. Campbell DJ and Koch MA. Phenotypical and functional specialization of FOXP3(+) regulatory T cells Nat. Rev. Immunol. 11:119-130, 2011
14. Campbell DJ and Koch MA. T(reg) cells: patrolling a dangerous neighborhood Nat. Med. 17:929-930, 2011
15. Campbell DJ. Regulatory T cells GATA have it Immunity. 35:313-315, 2011
16. Chiba T, Chang MY, Wang S, Wight TN, McMillen TS, Oram JF, Vaisar T, Heinecke JW, De Beer FC, De Beer MC, and Chait A. Serum Amyloid A Facilitates the Binding of High-Density Lipoprotein From Mice Injected With Lipopolysaccharide to Vascular Proteoglycans Arterioscler. Thromb. Vasc. Biol. 2011
17. Chow IT, James EA, Tan V, Moustakas AK, Papadopoulos GK, and Kwok WW. DRB1*12:01 presents a unique subset of epitopes by preferring aromatics in pocket 9 Mol. Immunol. 2011
18. Delong JH, Simpson KH, Wambre E, James EA, Robinson D, and Kwok WW. Ara h 1-reactive T cells in individuals with peanut allergy J. Allergy Clin. Immunol. 127:1211-1218, 2011
19. Eaton JE, Silveira MG, Pardi DS, Sinakos E, Kowdley KV, Luketic VA, Harrison ME, McCashland T, Befeler AS, Harnois D, Jorgensen R, Petz J, and Lindor KD. High-dose ursodeoxycholic acid is associated with the development of colorectal neoplasia in patients with ulcerative colitis and primary sclerosing cholangitis Am. J. Gastroenterol. 106:1638-1645, 2011
20. Evanko SP, Potter-Perigo S, Bollyky PL, Nepom GT, and Wight TN. Hyaluronan and versican in the control of human T-lymphocyte adhesion and migration Matrix Biol. 2011
21. Fu Y, Nagy JA, Brown LF, Shih SC, Johnson PY, Chan CK, Dvorak HF, and Wight TN. Proteolytic Cleavage of Versican and Involvement of ADAMTS-1 in VEGF-A/VPF-Induced Pathological Angiogenesis J. Histochem. Cytochem. 59:463-473, 2011
22. Gallagher MP, Goland RS, and Greenbaum CJ. Making progress: preserving beta cells in type 1 diabetes Ann. N. Y. Acad. Sci. 1243:119-134, 2011
23. Ge X, James EA, Reijonen H, and Kwok WW. Differences in self-peptide binding between T1D-related susceptible and protective DR4 subtypes J. Autoimmun. 2011
24. Glatigny S, Duhen R, Oukka M, and Bettelli E. Cutting Edge: Loss of alpha4 Integrin Expression Differentially Affects the Homing of Th1 and Th17 Cells J. Immunol. 2011
25. Greenbaum CJ and Atkinson MA. Persistence is the twin sister of excellence: an important lesson for attempts to prevent and reverse type 1 diabetes Diabetes 60:693-694, 2011
26. Greenbaum CJ, Buckingham B, Chase H, and Krischer J. Metabolic Tests to Determine Risk for Type 1 Diabetes in Clinical Trials. Diabetes Metab Res. Rev. 2011
27. Greenbaum CJ, McCulloch-Olson M, Chiu HK, Palmer JP, and Brooks-Worrell B. Parenteral insulin suppresses T cell proliferation to islet antigens. Pediatr. Diabetes 12:150-155, 2011
28. Gruessner RW, Pugliese A, Reijonen HK, Gruessner S, Jie T, Desai C, Sutherland DE, and Burke GW III. Development of diabetes mellitus in living pancreas donors and recipients Expert. Rev. Clin. Immunol. 7:543-551, 2011
29. Guo Y, Audry M, Ciancanelli M, Alsina L, Azevedo J, Herman M, Anguiano E, Sancho-Shimizu V, Lorenzo L, Pauwels E, Philippe PB, Perez de Diego R, Cardon A, Vogt G, Picard C, Andrianirina ZZ, Rozenberg F, Lebon P, Plancoulaine S, Tardieu M, Valerie D, Jouanguy E, Chaussabel D, Geissmann F, Abel L, Casanova JL, and Zhang SY. Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity J. Exp. Med. 208:2083-2098, 2011
30. Hambleton S, Salem S, Bustamante J, Bigley V, Boisson-Dupuis S, Azevedo J, Fortin A, Haniffa M, Ceron-Gutierrez L, Bacon CM, Menon G, Trouillet C, McDonald D, Carey P, Ginhoux F, Alsina L, Zumwalt TJ, Kong XF, Kumararatne D, Butler K, Hubeau M, Feinberg J, Al-Muhsen S, Cant A, Abel L, Chaussabel D, Doffinger R, Talesnik E, Grumach A, Duarte A, Abarca K, Moraes-Vasconcelos D, Burk D, Berghuis A, Geissmann F, Collin M, Casanova JL, and Gros P. IRF8 Mutations and Human Dendritic-Cell Immunodeficiency N. Engl. J. Med. 2011
31. Harada M, Hirota T, Jodo AI, Hitomi Y, Sakashita M, Tsunoda T, Miyagawa T, Doi S, Kameda M, Fujita K, Miyatake A, Enomoto T, Noguchi E, Masuko H, Sakamoto T, Hizawa N, Suzuki Y, Yoshihara S, Adachi M, Ebisawa M, Saito H, Matsumoto K, Nakajima T, Mathias RA, Rafaels N, Barnes KC, Himes BE, Duan QL, Tantisira KG, Weiss ST, Nakamura Y, Ziegler SF, and Tamari M. Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma Am. J. Respir. Cell Mol. Biol. 44:787-793, 2011
32. Harten IA, Zahr RS, Lemire JM, Machan JT, Moses MA, Doiron RJ, Curatolo AS, Rothman FG, Wight TN, Toole BP, Gordon LB. Age-dependent loss of MMP-3 in Hutchinson-Gilford Progeria Syndrome. J Gerontol A Biol Sci Med Sci. 66:1201-7, 2011.
33. Harten IA, Zahr RS, Lemire JM, Machan JT, Moses MA, Doiron RJ, Curatolo AS, Rothman FG, Wight TN, Toole BP, and Gordon LB. Age-dependent loss of MMP-3 in Hutchinson-Gilford progeria syndrome J. Gerontol. A Biol. Sci. Med. Sci. 66:1201-1207, 2011
34. Hernaez R, Yeung E, Clark JM, Kowdley KV, Brancati FL, and Kao WH. Hemochromatosis gene and nonalcoholic fatty liver disease: a systematic review and meta-analysis J. Hepatol. 2011
35. Ho MT, Kelly EJ, Bodor M, Bui T, Kowdley KV, and Ho RJ. Novel cytochrome P450-2D6 promoter sequence variations in hepatitis C positive and negative subjects Ann. Hepatol. 10:327-332, 2011
36. Imam MH, Sinakos E, Gossard AA, Kowdley KV, Luketic VA, Harrison M, McCashland T, Befeler AS, Harnois D, Jorgensen R, Petz J, Keach J, Decook AC, Enders F, and Lindor KD. High-dose ursodeoxycholic acid increases risk of adverse outcomes in patients with early stage primary sclerosing cholangitis Aliment. Pharmacol. Ther. 34:1185-1192, Immunol. 2011
37. Irani S, Kowdley K, Kozarek R. Gastric varices: an updated review of management. J Clin Gastroenterol. 45(2):133-48, 2011
38. Ito H and Hamerman JA. TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells Eur. J. Immunol. 2011
39. James EA and Kwok WW. Autoreactive CD4(+) T cells in patients with atopic dermatitis J. Allergy Clin. Immunol. 128:100-101, 2011
40. James EA, Devoti JA, Rosenthal DW, Hatam LJ, Steinberg BM, Abramson AL, Kwok WW, and Bonagura VR. Papillomavirus-Specific CD4+ T Cells Exhibit Reduced STAT-5 Signaling and Altered Cytokine Profiles in Patients with Recurrent Respiratory Papillomatosis J. Immunol. 2011
41. James EA, Mallone R, Schloot NC, Gagnerault MC, Thorpe J, Fitzgerald-Miller L, Reichow J, Wagner R, Pham MN, Jospe N, Lou O, Gottlieb PA, Brooks-Worrell BM, Durinovic-Belló I. Immunology of Diabetes Society T-Cell Workshop: HLA class II tetramer-directed epitope validation initiative. Diabetes Metab Res Rev 2011; 27: Eupub. DOI: 10.1002/dmrr.1244
42. James EA, van Haren SD, Ettinger RA, Fijnvandraat K, Liberman JA, Kwok WW, Voorberg J, and Pratt KP. T-cell responses in two unrelated hemophilia A inhibitor subjects include an epitope at the factor VIII R593C missense site J. Thromb. Haemost. 2011
43. Kawamoto S, Flynn JP, Shi Q, Sakr SW, Luo J, Allen MD. Heme oxygenase-1 induction enhances cell survival and restores contractility to unvascularized three-dimensional adult cardiomyocyte grafts implanted in vivo. Tissue Eng Part A. 2011 Feb 3. [Epub ahead of print]
44. Kean TJ, Duesler L, Young RG, Dadabayev A, Olenyik A, Penn M, Wagner J, Fink DJ, Caplan AI, and Dennis JE. Development of a peptide-targeted, myocardial ischemia-homing, mesenchymal stem cell J. Drug Target 2011
45. Khadra A, Pietropaolo M, Nepom GT, and Sherman A. Investigating the role of T-cell avidity and killing efficacy in relation to type 1 diabetes prediction PLoS. One. 6:e14796
46. Killebrew JR, Perdue N, Kwan A, Thornton AM, Shevach EM, and Campbell DJ. A Self-Reactive TCR Drives the Development of Foxp3+ Regulatory T Cells That Prevent Autoimmune Disease J. Immunol. 187:861-869, 2011
47. Kistler KD, Brunt EM, Clark JM, Diel AM, Sallis JF, and Schwimmer JB, for the NASH CRN Research Group [Kowdley KV]: Physical activity recommendations, exercise intensity, and histological severity of nonalcoholic fatty liver disease. Am J Gastroenterol 2011 Mar;106(3):460-8. Epub 2011 Jan 4.
48. Kitajima M, Ito T, Tumes DJ, Endo Y, Onodera A, Hashimoto K, Motohashi S, Yamashita M, Nishimura T, Ziegler SF, and Nakayama T. Memory type 2 helper T cells induce long-lasting antitumor immunity by activating natural killer cells Cancer Res. 71:4790-4798, 2011
49. Kitajima M, Lee HC, Nakayama T, and Ziegler SF. TSLP enhances the function of helper type2 cells Eur. J. Immunol. 2011
50. Kornum BR, Kawashima M, Faraco J, Lin L, Rico TJ, Hesselson S, Axtell RC, Kuipers H, Weiner K, Hamacher A, Kassack MU, Han F, Knudsen S, Li J, Dong X, Winkelmann J, Plazzi G, Nevsimalova S, Hong SC, Honda Y, Honda M, Hogl B, Ton TG, Montplaisir J, Bourgin P, Kemlink D, Huang YS, Warby S, Einen M, Eshragh JL, Miyagawa T, Desautels A, Ruppert E, Hesla PE, Poli F, Pizza F, Frauscher B, Jeong JH, Lee SP, Strohl KP, Longstreth WT Jr, Kvale M, Dobrovolna M, Ohayon MM, Nepom GT, Wichmann HE, Rouleau GA, Gieger C, Levinson DF, Gejman PV, Meitinger T, Peppard P, Young T, Jennum P, Steinman L, Tokunaga K, Kwok PY, Risch N, Hallmayer J, and Mignot E. Common variants in P2RY11 are associated with narcolepsy Nat. Genet. 43:66-71, 2011
51. Kotturi MF, Swann JA, Peters B, Arlehamn CL, Sidney J, Kolla RV, James EA, Akondy RS, Ahmed R, Kwok WW, Buchmeier MJ, and Sette A. Human CD8+ and CD4+ T Cell Memory to Lymphocytic Choriomeningitis Virus Infection J. Virol. 85:11770-11780, 2011
52. Kowdley KV, Belt P, Wilson LA, Yeh MM, Neuschwander-Tetri BA, Chalasani N, Sanyal AJ, and Nelson JE. Elevated serum ferritin is an independent predictor of histologic severity and advanced fibrosis among patients with nonalcoholic fatty liver disease Hepatology 2011
53. Kowdley KV, Wang CC, Welch S, Roberts H, and Brosgart CL. Prevalence of chronic hepatitis B among foreign-born persons living in the United States by country of origin Hepatology doi: 10.1002/hep.24804., Nov 22, 2011
54. Kreutziger KL, Muskheli V, Johnson P, Braun K, Wight TN, and Murry CE. Developing Vasculature and Stroma in Engineered Human Myocardium Tissue Eng Part A 2011
55. Lachin JM, McGee PL, Greenbaum CJ, Palmer J, Pescovitz MD, Gottlieb P, and Skyler J. Sample size requirements for studies of treatment effects on beta-cell function in newly diagnosed type 1 diabetes PLoS. One. 6:e26471-2011
56. Lavine JE, Schwimmer JB, Van Natta ML, Molleston JP, Murray KF, Rosenthal P, Abrams SH, Scheimann AO, Sanyal AJ, Chalasani N, Tonascia J, Ünalp A, Clark JM, Brunt EM, Kleiner DE, Hoofnagle JH, Robuck PR; Nonalcoholic Steatohepatitis Clinical Research Network[Kowdley KV]. Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial. JAMA. 305(16):1659-68. 2011
57. Long SA, Cerosaletti K, Wan JY, Ho JC, Tatum M, Wei S, Shilling HG, and Buckner JH. An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(+) T cells Genes Immun. 12:116-125, 2011
58. Long SA, Rieck M, Tatum M, Bollyky PL, Wu RP, Muller I, Ho JC, Shilling HG, and Buckner JH. Low-dose antigen promotes induction of FOXP3 in human CD4+ T cells J. Immunol. 187:3511-3520, 2011
59. Long SA. and Buckner JH. CD4+FOXP3+ T regulatory cells in human autoimmunity: more than a numbers game J. Immunol. 187:2061-2066, 2011
60. Longhi MS, Hussain MJ, Kwok WW, Mieli-Vergani G, Ma Y, and Vergani D. Autoantigen-specific regulatory T cells, a potential tool for immune-tolerance reconstitution in type-2 autoimmune hepatitis Hepatology 53:536-547, 2011
61. Lord JD, Hackman RC, Gooley TA, Wood BL, Moklebust AC, Hockenbery DM, Steinbach G, Ziegler SF, and McDonald GB. Blood and gastric FOXP3+ T cells are not decreased in human gastric graft-versus-host disease Biol. Blood Marrow Transplant. 17:486-496, 2011
62. Lord JD, Upton MP, and Hwang JH. Confocal endomicroscopic evaluation of colorectal squamous metaplasia and dysplasia in ulcerative colitis Gastrointest. Endosc. 73:1064-1066, 2011
63. Maliken BD, Nelson JE, and Kowdley KV. The hepcidin circuits act: Balancing iron and inflammation Hepatology 53:1764-1766, 2011
64. Mallone R, Mannering SI, Brooks-Worrell BM, Durinovic-Belló I, Cilio CM, Wong FS, and Schloot NC. Isolation and preservation of peripheral blood mononuclear cells for analysis of islet antigen-reactive T cell responses: position statement of the T-Cell Workshop Committee of the Immunology of Diabetes Society Clin. Exp. Immunol. 163:33-49, 2011
65. Mallone R, Scotto M, Janicki CN, James EA, Fitzgerald-Miller L, Wagner R, Gottlieb P, Thorpe J, Jospe N, Durinovic-Bellò I, Boitard C, Lou O, Dayan CM, Wong FS. Immunology of Diabetes Society T-Cell Workshop: HLA Class I Tetramer-Directed Epitope Validation Initiative. Diabetes Metab Res Rev 2011; 27: Eupub, DOI: 10.1002/dmrr.1245
66. Matsumoto S, Takita M, Chaussabel D, Noguchi H, Shimoda M, Sugimoto K, Itoh T, Chujo D, Sorelle J, Onaca N, Naziruddin B, and Levy MF. Improving Efficacy of Clinical Islet Transplantation with Iodixanol Based Islet Purification, Thymoglobulin Induction and Blockage of IL-1-beta and TNF-alpha Cell Transplant. 2011
67. Mattapallil MJ, Silver PB, Mattapallil JJ, Horai R, Karabekian Z, McDowell JH, Chan CC, James EA, Kwok WW, Sen HN, Nussenblatt RB, David CS, and Caspi RR. Uveitis-associated epitopes of retinal antigens are pathogenic in the humanized mouse model of uveitis and identify autoaggressive T cells J. Immunol. 187:1977-1985, 2011
68. McNab FW, Berry MP, Graham CM, Bloch SA, Oni T, Wilkinson KA, Wilkinson RJ, Kon OM, Banchereau J, Chaussabel D, and O'Garra A. Programmed Death Ligand 1 is over-expressed by neutrophils in the blood of patients with active Tuberculosis Eur. J. Immunol. 2011
69. Menard L, Saadoun D, Isnardi I, Ng YS, Meyers G, Massad C, Price C, Abraham C, Motaghedi R, Buckner JH, Gregersen PK, and Meffre E. The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans J. Clin. Invest 2011
70. Merrilees MJ, Beaumont BW, Braun KR, Thomas AC, Kang I, Hinek A, Passi A, and Wight TN. Neointima Formed by Arterial Smooth Muscle Cells Expressing Versican Variant V3 Is Resistant to Lipid and Macrophage Accumulation Arterioscler. Thromb. Vasc. Biol. 2011
71. Nelson JE, Klintworth H, Kowdley KV. Iron Metabolism in Nonalcoholic Fatty Liver Disease. Curr Gastroenterol Rpts.
72. Nelson JE, Wilson L, Brunt EM, Yeh MM, Kleiner DE, Unalp-Arida A, and Kowdley KV. Relationship between the pattern of hepatic iron deposition and histological severity in nonalcoholic fatty liver disease Hepatology 53:448-457, 2011
73. Nepom GT, St Clair EW, and Turka LA. Challenges in the pursuit of immune tolerance Immunol. Rev. 241:49-62, 2011
74. Orban T, Bundy B, Becker DJ, DiMeglio LA, Gitelman SE, Goland R, Gottlieb PA, Greenbaum CJ, Marks JB, Monzavi R, Moran A, Raskin P, Rodriguez H, Russell WE, Schatz D, Wherrett D, Wilson DM, Krischer JP, and Skyler JS. Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial. Lancet 378:412-419, 2011
75. Palomares O, Ruckert B, Jartti T, Kucuksezer UC, Puhakka T, Gomez E, Fahrner HB, Speiser A, Jung A, Kwok WW, Kalogjera L, Akdis M, and Akdis CA. Induction and maintenance of allergen-specific FOXP3(+) Treg cells in human tonsils as potential first-line organs of oral tolerance J. Allergy Clin. Immunol. 2011
76. Peng SL. Psoriatic Arthritis. Virginia Mason Med Ctr Bull 65: 32-35 (2011)
77. Pescovitz MD, Torgerson TR, Ochs HD, Ocheltree E, McGee P, Krause-Steinrauf H, Lachin JM, Canniff J, Greenbaum CJ, Herold KC, Skyler JS, and Weinberg A. Effect of rituximab on human in vivo antibody immune responses J. Allergy Clin.
78. Peters A, Pitcher LA, Sullivan JM, Mitsdoerffer M, Acton SE, Franz B, Wucherpfennig K, Turley S, Carroll MC, Sobel RA, Bettelli E, and Kuchroo VK. Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation Immunity. 35:986-996, 2011
79. Pido-Lopez J, Kwok WW, Mitchell TJ, Heyderman RS, and Williams NA. Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue PLoS. Pathog. 7:e1002396-2011
80. Poordad F, McCone J Jr, Bacon BR, Bruno S, Manns MP, Sulkowski MS, Jacobson IM, Reddy KR, Goodman ZD, Boparai N, DiNubile MJ, Sniukiene V, Brass CA, Albrecht JK, Bronowicki JP; SPRINT-2 Investigators [Kowdley KV]. Boceprevir for untreated chronic HCV genotype 1 infection. N Engl J Med. 364(13):1195-206. 2011
81. Pugliese A, Reijonen HK, Nepom GT, and Burke III GW. Recurrence of autoimmunity in pancreas transplant patients: research update Diabetes Manag. (Lond) 1:229-238, 2011
82. Quartier P, Allantaz F, Cimaz R, Pillet P, Messiaen C, Bardin C, Bossuyt X, Boutten A, Bienvenu J, Duquesne A, Richer O, Chaussabel D, Mogenet A, Banchereau J, Treluyer JM, Landais P, and Pascual V. A multicentre, randomised, double-blind, placebo-controlled trial with the interleukin-1 receptor antagonist anakinra in patients with systemic-onset juvenile idiopathic arthritis (ANAJIS trial) Ann. Rheum. Dis. 70:747-754, 2011
83. Raddassi K, Kent SC, Yang J, Bourcier K, Bradshaw EM, Seyfert-Margolis V, Nepom GT, Kwok WW, and Hafler DA. Increased Frequencies of Myelin Oligodendrocyte Glycoprotein/MHC Class II-Binding CD4 Cells in Patients with Multiple Sclerosis J. Immunol. 187:1039-1046, 2011
84. Raincrow JD, Dewar K, Stocsits C, Prohaska SJ, Amemiya CT, Stadler PF, Chiu CH. Hox clusters of the bichir (Actinopterygii, Polypterus senegalus) highlight unique patterns of sequence evolution in gnathostome phylogeny. J Exp Zool B Mol Dev Evol. 2011 Jun 17.
85. Reardon C, Lechmann M, Brustle A, Gareau MG, Shuman N, Philpott D, Ziegler SF, and Mak TW. Thymic Stromal Lymphopoetin-Induced Expression of the Endogenous Inhibitory Enzyme SLPI Mediates Recovery from Colonic Inflammation Immunity. 2011, Aug 3. [Epub ahead of print]
86. Redhu NS, Saleh A, Lee HC, Halayko AJ, Ziegler SF, and Gounni AS. IgE induces transcriptional regulation of thymic stromal lymphopoietin in human airway smooth muscle cells J. Allergy Clin. Immunol. 2011, Aug 9. [Epub ahead of print]
87. Reed MJ, Damodarasamy M, Vernon RB (2011) Angiogenesis in vitro utilizing murine vascular explants in miniaturized 3-dimensional collagen gels. The Open Circulation and Vascular Journal (TOCVJ), 4:12-17.
88. Reed MJ, Damodarasamy M, Vernon RB (2011) Angiogenesis in vitro utilizing murine vascular explants in miniaturized 3-dimensional collagen gels. The Open Circulation and Vascular Journal (TOCVJ), 4:12-17. Open Access
89. Risques RA, Lai LA, Himmetoglu C, Ebaee A, Li L, Feng Z, Bronner MP, Al-Lahham B, Kowdley KV, Lindor KD, Rabinovitch PS, and Brentnall TA. Ulcerative colitis-associated colorectal cancer arises in a field of short telomeres, senescence, and inflammation Cancer Res. 71:1669-1679, 2011
90. Robins H, Desmarais C, Matthis J, Livingston R, Andriesen J, Reijonen H, Carlson C, Nepom GT, Yee C, and Cerosaletti K. Ultra-sensitive detection of rare T cell clones J. Immunol. Methods 2011
91. Roth CL, Elfers CT, Figlewicz DP, Melhorn SJ, Morton GJ, Hoofnagle A, Yeh MM, Nelson JE, and Kowdley KV. Vitamin D deficiency in obese rats exacerbates NAFLD and increases hepatic resistin and toll-like receptor activation Hepatology 2011
92. Sanda S and Greenbaum CJ. Comment on: Atkinson. It's time to consider changing the rules: the rationale for rethinking control groups in clinical trials aimed at reversing type 1 diabetes. Diabetes 2011;60:361-363 Diabetes 60:e17, 2011
93. Sanyal AJ, Brunt EM, Kleiner DE, Kowdley K, Chalasani N, Lavine J, Ratziu V, McCullough A. Endpoints and clinical trial design for nonalcoholic steatohepatitis. Hepatology. 2011 Apr 21. [Epub ahead of print]
94. Schlenker C, Halterman T, and Kowdley KV. Rheumatologic disease and the liver Clin. Liver Dis. 15:153-164, 2011
95. Schneider A and Buckner JH. Assessment of Suppressive Capacity by Human Regulatory T Cells Using a Reproducible, Bi-Directional CFSE-Based In Vitro Assay Methods Mol. Biol. 707:233-241, 2011
96. Siddique A, Kowdley KV. Insulin resistance and other metabolic risk factors in the pathogenesis of hepatocellular carcinoma. Clin Liver Dis. 2011 May;15(2):281-96.
97. Siracusa MC, Saenz SA, Hill DA, Kim BS, Headley MB, Doering TA, Wherry EJ, Jessup HK, Siegel LA, Kambayashi T, Dudek EC, Kubo M, Cianferoni A, Spergel JM, Ziegler SF, Comeau MR, and Artis D. TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation Nature 2011, Aug 14. doi: 10.1038/nature10329.
98. Smith JJ, Sumiyama K, and Amemiya CT. A living fossil in the genome of a living fossil: Harbinger transposons in the coelacanth genome Mol. Biol. Evol. 2011
99. Snir O, Rieck M, Gebe JA, Yue BB, Rawlings CA, Nepom GT, Malmstrom V, and Buckner JH. Identification and functional characterization of T cells reactive to citrullinated-vimentin in HLA-DRB1*0401 humanized mice and RA patients Arthritis Rheum. 2011
100. Sosenko JM, Mahon J, Rafkin L, Lachin JM, Krause-Steinrauf H, Krischer JP, Cuthbertson D, Palmer JP, Thompson C, Greenbaum CJ, and Skyler JS. A comparison of the baseline metabolic profiles between Diabetes Prevention Trial-Type 1 and TrialNet Natural History Study participants. Pediatr. Diabetes 12:85-90, 2011
101. Sosenko JM, Skyler JS, Mahon J, Krischer JP, Beam CA, Boulware DC, Greenbaum CJ, Rafkin LE, Cowie C, Cuthbertson D, and Palmer JP. Validation of the Diabetes Prevention Trial-Type 1 Risk Score in the TrialNet Natural History Study. Diabetes Care 34:1785-1787, 2011
102. Subramanian S, Goodspeed L, Wang SA, Kim J, Zeng L, Ioannou GN, Haigh WG, Yeh MM, Kowdley KV, O'Brien KD, Pennathur S, and Chait A. Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice J. Lipid Res. 2011
103. Thompson LJ, Valladao AC, and Ziegler SF. Cutting edge: de novo induction of functional foxp3+ regulatory CD4 T cells in response to tissue-restricted self antigen J. Immunol. 186:4551-4555, 2011
104. Tong MJ, Pan CQ, Hann HW, Kowdley KV, Han SH, Min AD, and Leduc TS. The management of chronic hepatitis B in Asian Americans Dig. Dis. Sci. 56:3143-3162, 2011
105. Tridgell DM, Spiekerman C, Wang RS, and Greenbaum CJ. Interaction of onset and duration of diabetes on the percent of gad and ia-2 antibody-positive subjects in the type 1 diabetes genetics consortium database. Diabetes Care 34:988-993, 2011
106. Walker BJ, Neal JM, Mulroy MF, Humsi JA, Bittner RC, McDonald SB. Lidocaine pretreatment with tourniquet versus lidocaine-propofol admixture for attenuating propofol injection pain: A randomized controlled (BRI-Approved) trial. Reg Anesth Pain Med;36:41-45, 2011
107. Wambre E, Delong JH, James EA, Lafond RE, Robinson D, and Kwok WW. Differentiation stage determines pathologic and protective allergen-specific CD4(+) T-cell outcomes during specific immunotherapy J. Allergy Clin. Immunol. 2011
108. Wherrett DK, Bundy B, Becker DJ, DiMeglio LA, Gitelman SE, Goland R, Gottlieb PA, Greenbaum CJ, Herold KC, Marks JB, Monzavi R, Moran A, Orban T, Palmer JP, Raskin P, Rodriguez H, Schatz D, Wilson DM, Krischer JP, and Skyler JS. Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial. Lancet 378:319-327, 2011
109. Wight TN and Potter-Perigo S. The Extracellular Matrix: An Active or Passive Player in Fibrosis Am. J. Physiol Gastrointest. Liver Physiol 2011
110. Wight TN, Toole BP, Hascall VC. Hyaluronan and the aggregating proteoglycans. In: The Extracellular Matrix: an Overview, Mecham RP, ed. Springer-Verlag Berlin Heidelberg, pp. 147-195, 2011.
111. Wilkinson-Berka JL, Tan G, Binger KJ, Sutton L, McMaster K, Deliyanti D, Perera G, Campbell DJ, and Miller AG. Aliskiren reduces vascular pathology in diabetic retinopathy and oxygen-induced retinopathy in the transgenic (mRen-2)27 rat Diabetologia 2011
112. Wisler BA, Dennis JE, Malemud CJ. (2011) New organ-specific pharmacological strategies interfering with signaling pathways in inflammatory disorders/autoimmune disorders. Curr. Signal Transduction Ther. 6:279-291.