Michael G. Kinsella, PhD
Title:
Research Associate Member
Email Address:
Phone Number:
206-341-1318
Background
Dr. Kinsella attended the University of Washington, from which he received his Bachelor of Science degree in Biology. His received his PhD in Developmental Neurobiology in 1978 from the University of Oregon. After post-doctoral work in heart developmental mechanisms and as an Instructor of Histology and Embryology in the Department of Anatomy and Cell Biology at the Medical University of South Carolina, he returned to Seattle, joining the University of Washington Department of Pathology Faculty in 1987, where he remains an Affiliate Professor. In 2000, Dr. Kinsella joined the Hope Heart Institute. Since 2005 he has been a Research Associate Member within the Hope Heart Program of the Benaroya Research Institute at Virginia Mason.
Areas of Research
Dr Kinsella leads research efforts to understand how the molecular environment of cells within blood vessels helps to regulate vascular cell responses during development, injury and disease. A central project in this laboratory seeks to understand how a large macromolecule in the extracellular matrix (perlecan) regulates cell proliferation in the artery wall and reduces inflammation of the blood vessels. These processes are important both during development of atherosclerosis and the restenotic remodeling of vessels after surgical intervention to repair narrowed or damaged arteries. These studies may provide a novel approach to limit narrowing of blood vessels due to hyper-proliferation of vessel wall cells, and to regulate immune responses to vascular disease.
Selected Publications
Kinsella MG and Fitzharris TP. Origin of cushion tissue in the developing chick heart: Cinematographic recordings of in situ formation. Science 207:1359-1360, 1980.
Kinsella MG and Wight TN. Modulation of sulfated proteoglycan synthesis by bovine aortic endothelial cells during migration. J Cell Biol 102:679-687,1986.
Weiser MCM, Grieshaber SS, Belknap JK, Kinsella MG and Majack RA. Developmental regulation of perlecan gene expression in aortic smooth muscle cells. Matrix Biol 15:331-340, 1996.
Kinsella MG, Fischer JW, Mason DP and Wight TN. Retrovirally-mediated expression of decorin by macrovascular endothelial cells: effects on cellular migration and fibronectin fibrillogenesis in vitro. J Biol Chem 275:13924-13932, 2000.
Fischer JW, Kinsella MG, Clowes M, Clowes AW and Wight TN. Local expression of bovine decorin by cell-mediated gene transfer reduces neointimal formation after balloon injury in rats. Circ Res 86:676-683.
Kinsella MG, Tran, PK, Weiser-Evans MC, Reidy M, Majack RA and Wight TN. Changes in perlecan expression during vascular injury: role in the inhibition of smooth muscle cell proliferation in the late lesion. Arterioscler Thromb Vasc Biol 23:608-614, 2003.
Kinsella MG and Wight TN. Perlecan: An extracellular matrix heparan sulfate proteoglycan that regulates key events in vascular development and disease. pp 607-636. In “Chemistry and Biology of Heparin and Heparan Sulfate“. H.G. Garg, R.L. Lindhart, and C.A. Hales, eds. Elsevier, Ltd, Oxford, UK. 2005.
Tran-Lundmark K, Tran PK, Rauch BH, Ekstrand J, Wight, TN, Hedin U and Kinsella MG. Heparan sulfate chains on perlecan are required for the inhibition of arterial smooth muscle cell proliferation by all-trans retinoic acid. Atheroscler Thromb. Vasc Biol (in press), 2008