Our Research
Estelle Bettelli, PhD
Title:
Assistant Member
Email Address:
Phone Number:
206-287-1022
Background
Dr. Bettelli received her BS in Cellular Biology from the University Pierre et Marie Currie (Paris 6) in 1995 and her PhD in Hematology/Immunology from the University Denis Diderot (Paris 7) in 2001. Following a postdoctoral fellowship and after serving as an Instructor in the Department of Neurology at the Brigham and Women’s Hospital, Boston, she served as an Assistant Professor at Harvard Medical School. Dr. Bettelli joined the faculty of the Benaroya Research Institute as an Assistant Member in 2009. She is also an Affiliate Assistant Professor in the Department of Immunology at the University of Washington School of Medicine.
Areas of Research
Research in Dr. Bettelli's laboratory is focused on understanding the development, regulation and functions of the adaptive immune system in cancer and autoimmune diseases such as multiple sclerosis. In particular, we are studying how to modulate and control a population of leukocytes called T helper 17 (Th17) cells, which are believed to be highly pathogenic in autoimmunity and could play an important role in cancer.
Selected Publications
Awasthi A, Riol-Blanco L, Jäger A, Korn T, Pot C, Galileos G, Bettelli E, Kuchroo VK, Oukka M. Cutting edge: IL-23 receptor gfp reporter mice reveal distinct populations of IL-17-producing cells. J Immunol. 2009 May 15;182(10):5904-8.
Frommer F, Heinen TJ, Wunderlich FT, Yogev N, Buch T, Roers A, Bettelli E, Müller W, Anderton SM, Waisman A. Tolerance without clonal expansion: self-antigen-expressing B cells program self-reactive T cells for future deletion. J Immunol. 2008 Oct 15;181(8):5748-59.
Bettelli E, Korn T. Oukka M, Kuchroo VK. Th17 cells: Induction and effector functions. Nature. 2007; 453:1051-7.
Bettelli E, Oukka M, Kuchroo VK. T(H)-17 cells in the circle of immunity and autoimmunity. Nat Immunol. 2007;8:345-50.
Korn T, Bettelli E, Gao W, Awasthi A, Jäger A, Strom TB, Oukka M, Kuchroo VK. IL-21 initiates an alternate pathway to induce proinflammatory Th17 cells. Nature. 2007; 448:484-7.
Bettelli E, Korn T, Kuchroo VK. Th17: the third member of the effector T cell Trilogy. Curr. Opin. Immunol. 2007;19(6):652-7.
Bettelli E, Carrier Y., Gao W, Korn T., Strom T., Oukka M., Weiner H.L., Kuchroo V.K. Reciprocal developmental pathways for the generation of pathogenic effector (Th-IL-17) and regulatory (CD4+CD25+, Foxp3+) T cells. Nature. 2006;441:235-8.
Bettelli E, Baeten D, Jager A, Sobel RA, Kuchroo VK. Myelin oligodendrocyte glycoprotein-specific T and B cells cooperate to induce a Devic-like disease in mice. J Clin Invest. 2006;116:2393-2402.