Study Name: TrialNet Natural History Study

Principal Investigator: Carla Greenbaum, MD

Phone: 1-800-888-4187

Email: diabetes@BenaroyaResearch.org

What is the TrialNet Natural History Study?

TrialNet is screening relatives of people with Type 1 diabetes to find out if these family members are at risk for developing diabetes. Relatives of people with Type 1 diabetes have about a 3-4 percent chance of testing positive for autoantibodies associated with diabetes. If you learn you are at risk for developing Type 1 diabetes, additional test will be offered to estimate your chances of developing Type 1 diabetes. If you qualify, you may have an opportunity to be enrolled in either a Natural History or Prevention Study. All research volunteers will be closely monitored for early detection of Type 1 diabetes. Early detection of Type 1 diabetes may improve your blood sugar control and reduce your chances of developing complications. You will be part of a research program that may help other people at risk for Type 1 diabetes.

Who can participate?

• Individuals who are 1-45 years of age with a parent, child, brother, or sister with Type 1 diabetes

• Individual who are 1-20 years of age with a niece, nephew, aunt, uncle, grandparent, half-sibling or cousin with Type 1 diabetes

Note: A relative diagnosed before the age of 40 AND started on insulin within the first year of diagnosis may have Type 1 diabetes.

What will study participants be asked to do?

Screening involves a simple blood test for the presence of diabetes-related autoantibodies that may appear years before Type 1 diabetes develops. TrialNet has established screening sites throughout North America. Please contact us to find a screening location near you, or to a request a test kit.