This is a research study for patients with malignant brain tumor who require chronic administration of high-dose dexamethasone. The study will compare the efficacy of human Corticotropin-Releasing Factor (hCRF) to placebo (sugar pill) in treating the symptoms of peritumoral brain edema (swelling).

-Potential subjects are 18 years of age or older with diagnosis of a primary or metastatic brain tumor -Must have required treatment with dexamethasone to control the symptoms of brain swelling

If eligible, subjects will be assigned to one of
two groups. One group will receive study drug
(hCRF), and the other will receive placebo.
Neither you nor the study team will know which
group you are assigned to. Subjects will receive
study drug for 12 weeks, during which they will
be asked to return to the clinic periodically for
clinical evaluations. These evaluations may
include physical and neurological exams,
electrocardiogram (ECG-tracing of the electrical
activity of the heart), documentation of
subject's blood pressure, pulse, temperature,
height and weight, as well as routine blood and
urine testing.

Study Summary:

Detailed Study Description:

Study Design: Interventional
Phase of Study: n/a
Study Type: Interventional
Condition or Study Focus: Brain Cancer
Intervention Type: Drug
Intervention Name: Corticotropin-Releasing Factor (hCRF)
Gender: Male and Female
Age group: Interventional
Sponsor: __