Select another study category: Amyotrophic Lateral Sclerosis AnesthesiologyCancer Control/Symptom PreventionCancer, BladderCancer, BrainCancer, BreastCancer, ColorectalCancer, EsophagealCancer, GeneralCancer, GynecologicCancer, Head and NeckCancer, HIV/AIDS MalignancyCancer, LiverCancer, LungCancer, LymphomaCancer, MelanomaCancer, NeuroendocrineCancer, PancreaticCancer, ProstateCancer, RenalCancer, Solid TumorsCardiologyCrohn's DiseaseDiabetes, Type 1Fatty Liver DiseaseHealthy ControlsHepatitisHepatorenal SyndromeLiver Disease RegistryLupusMultiple SclerosisOtherParkinson's DiseasePrimary Biliary CirrhosisPrimary Sclerosing CholangitisRadiologyRelapsing PolychondritisRheumatoid ArthritisSclerodermaSphincter of Oddi DysfunctionStrokeUrology

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Cancer, Breast

BRI researchers are conducting clinical trials dedicated to finding the causes of breast cancer and increasing the effectiveness of its treatment. Current research focuses on areas such as surgical techniques, radiation therapies, and post-surgical treatments.

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To participate in a BRI clinical trial, please contact the study coordinator listed in each of the study links below, or send an e-mail to the Clinical Research Program. Please click on individual studies for more information.

Studies currently accepting study participants:

• A Phase III Clinical Trial Comparing Trastuzumab Given Concurrently with Radiation Therapy and Radiation Therapy Alone for Women with HER2-Positive Ductal Carcinoma In Situ Resected by Lumpectomy (NSABP B-43)
• A Phase III Trial of Accelerated Whole Breast Irradiation With Hypofractionation Plus Concurrent Boost Versus Standard Whole Breast Irradiation Plus Sequential Boost for Early-Stage Breast Cancer (R1005)
• A Phase III, Randomized Clinical Trial of Standard Adjuvant Endocrine Therapy +/- Chemotherapy in Patients with 1-3 Positive Nodes, Hormone Receptor-Positive and HER-2 Negative Breast Cancer with Recurrence Score (RS) of 25 or Less (SWOG 1007)
• A Randomized Phase III Trial of Adjuvant Therapy Comparing Chemotherapy Alone to Chemotherapy Plus Trastuzumab in Women With Node- Positive or High-Risk Node-Negative HER2-Low Invasive Breast Cancer (NSABP B-47)
• Randomized Phase III Trial of Paclitaxel + Trastuzumab + Lapatinib Versus Paclitaxel + Trastuzumab as Neoadjuvant Treatment of HER2-Positive Primary Breast Cancer
• Randomized Trial of Metformin Versus Placebo On Recurrence And Survival in Early Stage Breast Cancer (MA32)

Studies currently not accepting study participants:

• Adjuvant Bisphosphonate therapy for state I - III Breast Cancer
• LPT111111- Single Arm study to evaluate the combination of weekly Nab-Paclitaxel & Lapatinib as 1st-line or 2nd-line treatment in Women with ErbB2 Overexpressing Metastatic Breast Cancer
• PACCT-1: Program for the Assessment of Clinical Cancer Tests - Trial Assigning Individualized Option for Treatment (TAILORx)
• Partial Breast Irradiation to the lumpectomy cavity for early stage breast cancer (Stage 0-IIA)
• Post menopausal women after 5 years of hormone therapy, Aromatase Inhibitor (AC) or Tamoxifen
• Post menopausal women with newly diagnosed Stage I - III