Baohong Cao, MD, PhD
Title:
Research Assistant Member
Email Address:
Phone Number:
206-341-1943
Background
After completing his medical degree at Shanxi Medical University, Dr. Baohong Cao did post-graduate training at two of China’s top universities, obtaining a master’s degree in surgery at Fudan University in Shanghai, focusing on human cancer biology, and his PhD in molecular biology at Peking University in Beijing. He then did his postdoctoral training, first in Copenhagen, Denmark, and then in the laboratory of Dr. Johnny Huard in the Department of Orthopedic Surgery at the University of Pittsburg’s Stem Cell Research Center. He joined the faculty at the University of Pittsburg as an Assistant Professor in 2003. In 2007, he was recruited to join Dr. Margaret Allen’s Laboratory at Benaroya Research Institute as a Research Assistant Member.
Areas of Research
At Pittsburg, Dr. Cao was a lead scientist in a research team that first discovered the existence of true stem cells in skeletal muscle. At BRI, he will continue his work in muscle-derived stem cells as a component of engineered tissues for skeletal muscle regeneration within the Center for Control of Inflammation and Tissue Repair. Additionally, his stem cell expertise and interest in muscle regeneration is being applied to heart muscle regeneration and myocardial infarct repair.
Selected Publications
Deasy BM, Lu A, Tebbets JC, Feduska JM, Schugar RC, Pollett JB, Sun B, Urish KL,Gharaibeh BM, Cao B, Rubin RT, Huard J. A role for cell sex in stem cell-mediated skeletal muscle regeneration: female cells have higher muscle regeneration efficiency. J Cell Biol 2007; 177:73-86.
Zheng B, Cao B, Crisan M, Sun B, Li G, Logar A, Yap S, Pollett JB, Drowley L, Cassino T,
Gharaibeh B, Deasy BM, Huard J, Peault B. Prospective identification of myogenic
endothelial cells in human skeletal muscle. Nat Biotechnol 2007; 25:1025-34.
Zheng B, Cao B, Li GH, Huard J. Mouse adipose-derived stem cells undergo multilineage differentiation in vitro but primarily osteogenic and chondrogenic differentiation in vivo. Tissue Eng. 2006; 12:1891-901
Cao B, Deasy BM, Pollett J, Huard J. Cell therapy for muscle regeneration and repair. Phys Med Rehabil Clin N Am. 2005;16:889-907.
Cao B and Huard J. Muscle-derived stem cells. Cell Cycle 2004; 3:104-7.
Kimura S, Ikezawa M, Cao B, Kanda Y, Pruchnic R, Cummins J, Huard J, Miike T, Suzuki S. Ex vivo gene transfer to mature skeletal muscle using adenovirus helper cells. J Gene Med 2004; 6:155-65.
Cao B, Bruder J, Kovesdi I, Huard J. Muscle stem cells can act as antigen-presenting cells: implication for gene therapy. Gene Ther. 2004; 11:1321-30.
Cao B, Zheng B, Jankowski RJ, Kimura S, Ikezawa M, Deasy B, Cummins J, Epperly M, Qu-Petersen Z, Huard J. Muscle stem cells differentiate into hematopoietic lineages but retain myogenic potential. Nat Cell Biol 2003; 5:640-6.
Deasy BM, Jankowski RJ, Payne TR, Cao B, Goff JP, Greenberger JS, Huard J. Modeling stem cell population growth: incorporating terms for proliferative heterogeneity. Stem Cells 2003; 21:536-45.
Ikezawa M, Cao B, Qu Z, Peng H, Xiao X, Pruchnic R, Kimura S, Miike T, Huard J. Dystrophin Delivery in Dystrophin-Deficient DMD(mdx) Skeletal Muscle by Isogenic Muscle-Derived Stem Cell Transplantation. Hum Gene Ther 2003; 14:1535-46.
Huard J, Cao B, Qu-Petersen Z. Muscle-derived stem cells: potential for muscle regeneration. Birth Defects Res Part C Embryo Today 2003; 69:230-7.
Jankowski RJ, Deasy BM, Cao B, Gates C, Huard J. The role of CD34 expression and cellular fusion in the regeneration capacity of myogenic progenitor cells. J Cell Sci 2002; 115:4361-74.
Cao B, Mytinger JR, Huard J. Adenovirus mediated gene transfer to skeletal muscle. Microsc Res Tech 2002; 58:45-51.
Qu-Petersen Z, Deasy B, Jankowski RJ, Ikezawa M, Cummins J, Pruchnic R, Mytinger J, Cao B, Gates C, Wernig A, Huard J. Identification of a novel population of muscle stem cells in mice: potential for muscle regeneration. J Cell Biol 2002; 157:851-64.
Cao B, Pruchnic R, Ikezawa M, Xiao X, Li J, Wickham TJ, Kovesdi I, Rudert WA, Huard J. The role of receptors in the maturation-dependent adenoviral transduction of myofibers. Gene Ther 2001; 8:627-37.
Yokoyama T, Huard J, Pruchnic R, Yoshimura N, Qu Z, Cao B, de Groat WC, Kumon H, Chancellor MB. Muscle-derived cell transplantation and differentiation into lower urinary tract smooth muscle. Urology 2001; 57:826-31.
Lee JY, Qu-Petersen Z, Cao B, Kimura S, Jankowski RJ, Cummins J, Usas A, Gates C, Robbins P, Wernig A, Huard J. Clonal isolation of muscle-derived cells capable of enhancing muscle regeneration and bone healing. J Cell Biol 2000; 150:1085-100.
Pruchnic R, Cao B, Peterson ZQ, Xiao X, Li J, Samulski RJ, Epperly M, Huard J. The use of adeno-associated virus to circumvent the maturation-dependent viral transduction of muscle fibers. Hum Gene Ther 2000; 11:521-36.
Cao B, Mortensen K, Tornehave D, Larsson LI. Apoptosis in rat gastric antrum: evidence that regulation by food intake depends on nitric oxide synthase. J Histochem Cytochem 2000; 48:123-31.
Kimura S, Ikezawa M, Pruchnic R, Balkir L, Qu Z, Lowenstein J, Takeda S, Gates C, Cao B, Miike T, Huard J. Persistent gene transfer to skeletal muscle mediated by stably transfected early myogenic progenitor cells. Basic Appl Myol 2000; 10:237-48.